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Zhong D.-K.,University of Sichuan | Tang D.,Chengdu University of Traditional Chinese Medicine | Xue L.,The Third Peoples Hospital of Chengdu | Wen J.,University of Sichuan | Li Y.-P.,University of Sichuan
Chinese Journal of Integrative Medicine

Objective: To review and assess the effect of single moxibustion for exercise-induced fatigue: (EIF). Methods: Computer-search for 8 medical databases and 5 clinical trail registries were conducted for: randomized controlled trials (RCTs), added with hand-search for 10 Chinese acupuncture-moxibustion journals and additional references. Data from included RCTs were pooled by RevMan5.1. Methodology quality of RCTs was judged by Cochrane Collaboration assessment tool while quality of primary outcomes was evaluated by GRADE3.2. Results: Five RCTs were finally included, all reported in small sample size with high risk of: bias. Comparisons on single moxibustion and rest relief (without treatment) were studied. Six outcomes were reported, all favored moxibustion to rest relief for EIF. Primary outcomes showed as rating of perceived exertion (RPE) with mean difference (MD)=−0.49, 95% confidence interval (CI) [−0.80, −0.19], 800-m race performance with MD=−2.21, 95% CI [−3.57, −0.85], and Harvard Step Index (HSI) with MD=14.75, 95% CI [8.35, 21.15]. Moreover, all primary outcomes as RPE, 800-m race performance and HSI were rated low quality. Conclusions: Single moxibustion might be considered effective for EIF. However, due to small samples of included RCTs, high risk of bias among studies and poor quality of primary outcomes and subjects restricted to Chinese athletes only, these results present limitation, and should be taken with caution for practice. More large-size studies with rigorous design are warranted to further test effectiveness of moxibustion for EIF. © 2014, Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg. Source

Tang Y.,The Third Peoples Hospital of Chengdu | Ma H.,University of Sichuan
Chinese Journal of Gastroenterology

The mechanism of stress induced intestinal barrier injury and the mechanistic role of mast cells (MC) have not yet been clarified. To investigate the mechanistic role of intestinal mucosal MC (IMMC) in acute stress induced intestinal mucosal barrier injury. Sprague-Dawley (SD) rats were randomly divided into normal control group (N group) and stress group (S group). Rats in S group were given acute cold/restraint stress and were further divided into S2h, S4h, S8h, S16h and S24h subgroups according to the time point of sacrificing after stress. Histological change of terminal ileum tissue was observed and the degree of damage was evaluated by Chiu's scoring system. IMMC number was counted by toluidine blue staining. The ultrastructure of intestinal tissue and IMMC was observed by transmission electron microscopy. The content of histamine in intestinal tissue was determined by ELISA. Chiu's score in S subgroups was significantly higher than that in N group (P<0.05), showing a crescendo-decrescendo trend with the highest value occurred in S8h subgroup. Compared with N group, IMMC counts in S2h and S4h subgroups were significantly increased (P<0.05), and no significant difference was found between S8h, S16h, S24h subgroups and N group (P>0.05). IMMC count was not correlated with Chiu's score (P>0.05). Severe ultrastructure damage of intestinal mucosa and degranulation of IMMC were observed in S subgroups. The content of histamine in S2h, S4h and S8h subgroups was significantly lower than that in N group (P<0.05), showing a decrescendo trend. No significant difference was found between S16h, S24h subgroups and N group (P>0.05). The histamine content was negatively correlated with Chiu's score (P=0.03). IMMC degranulation with release of inflammatory mediators is an important mechanism of acute stress induced intestinal mucosal barrier injury. Source

Zhou H.,Sichuan Cancer Hospital | Zeng C.,The Third Peoples Hospital of Chengdu | Wei Y.,Sichuan Cancer Hospital | Zhou J.,Sichuan Cancer Hospital | Yao W.,Sichuan Cancer Hospital

Background:Maintenance chemotherapy is widely provided to patients with small cell lung cancer (SCLC). However, the benefits of maintenance chemotherapy compared with observation are a subject of debate.Methodology and Principal Findings:To identify relevant literature, we systematically searched the Medline, Embase, and Cochrane Central Register of Controlled Trials databases. Eligible trials included patients with SCLC who either received maintenance chemotherapy (administered according to a continuous or switch strategy) or underwent observation. The primary outcome was 1-year mortality, and secondary outcomes were 2-year mortality, overall survival (OS), and progression-free survival (PFS). Of the 665 studies found in our search, we identified 14 relevant trials, which together reported data on 1806 patients with SCLC. When compared with observation, maintenance chemotherapy had no effect on 1-year mortality (odds ratio [OR]: 0.88; 95% confidence interval [CI]: 0.66-1.19; P = 0.414), 2-year mortality (OR: 0.82; 95% CI: 0.57-1.19; P = 0.302), OS (hazard ratio [HR]: 0.87; 95% CI: 0.71-1.06; P = 0.172), or PFS (HR: 0.87; 95% CI: 0.62-1.22; P = 0.432). However, subgroup analyses indicated that maintenance chemotherapy was associated with significantly longer PFS than observation in patients with extensive SCLC (HR, 0.72; 95% CI: 0.58-0.89; P = 0.003). Additionally, patients who were managed using the continuous strategy of maintenance chemotherapy appeared to be at a disadvantage in terms of PFS compared with patients who only underwent observation (HR, 1.27; 95% CI: 1.04-1.54; P = 0.018).Conclusions/Significance:Maintenance chemotherapy failed to improve survival outcomes in patients with SCLC. However, a significant advantage in terms of PFS was observed for maintenance chemotherapy in patients with extensive disease. Additionally, our results suggest that the continuous strategy is inferior to observation; its clinical value needs to be investigated in additional trials. © 2013 Zhou et al. Source

Hu Y.,University of Sichuan | Wang H.,The Third Peoples Hospital of Chengdu | Deng J.,University of Sichuan
Open Rheumatology Journal

To our knowledge, the possible unveiled interaction between adult-onset Still's disease (AOSD) with autoimmune thyroid disease (AITD) has never been reported although it is well established that systemic autoimmune disease may usually occur in relation to AITD. As increasingly clear links of AITD with other autoimmune disease such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and primary Sjögren's syndrome (pSS) have been reported, and the incidence of AOSD concurrent AITD draws our attention rapidly. In this study, we searched relevant literatures published in the past 30 years to explore that condition. © Hu et al. Source

NIU Q.,University of Sichuan | NIU Q.,Sichuan Engineering Technical College | LI S.,The Third Peoples Hospital of Chengdu | CHEN D.,University of Sichuan | And 2 more authors.

Iron is an essential cofactor for many basic metabolic pathways in pathogenic microbes and their hosts. It is also dangerous as it can catalyse the production of reactive free radicals. This dual character makes the host can either limit iron availability to invading microbes or exploit iron to induce toxicity to pathogens. Successful pathogens, including Leishmania species, must possess mechanisms to circumvent host's iron limitation and iron-induced toxicity in order to survive. In this review, we discuss the regulation of iron metabolism in the setting of infection and delineate the iron acquisition strategies used by Leishmania parasites and their subversions to host iron metabolism to overcome host's iron-related defences. Copyright © Cambridge University Press 2016 Source

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