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Cao D.,The Third Hospital of Chinese PLA | He X.-G.,Chongqing Medical University | Liu T.,Chongqing Medical University | Zhang Y.-M.,Chongqing Medical University | Ma J.-Z.,No 323 Hospital Of Chinese Pla
International Journal of Ophthalmology | Year: 2010

AIM: To quantitatively assess the peripapillary retinal nerve fiber layer thickness (RNFLT) in Chinese subjects whose ages ranged from 5 to 40 years old with optical coherence tomography (OCT) and to analyze the characteristics of the variation of the RNFLT parameters. METHODS: We chose 242 eyes of 121 normal subjects whose ages ranged from 5 to 40 years. After being inquired of medical history and proceeding the routine examination of ophthalmology, which include vision, slitlamp, ophthalmoscope, intraocular pressure, and optometry, we examined the eyes of the volunteers who met the standards of being examined by OCT. The peripapillary RNFL of all participants was imaged on Stratus OCT ™ 3000. RNFLT around the disc was determined with 3.4 mm diameter circling scan, and it was measured and analyzed with the RNFLT average analysis program. The data were analyzed with SPSS 13.0 commercial statistical software. RESULTS: The RNFLT (μm) of the normal subjects whose ages ranged from 5 to 40 years old in clock type (1-12) were 130.6 ± 24.9, 87.3 ± 20.6, 58.5 ± 11.9, 75.9 ± 15.6, 119.6 ± 21.3, 155.4 ± 25.5, 158.1 ± 21.7, 85.8 ± 17.1, 65.3 ± 10.5, 96.9 ± 15.9, 148.4 ± 18.7, 143.3 ± 25.9, respectively. The average RNFLT (μm) of those in the superior(S), nasal(N), inferior(I) and temporal (T) quadrant were 140.8 ± 16.6, 73.9 ± 13.1, 144.3 ± 16.3, and 82.7 ± 12.5, respectively, and Avg. Thick was 110.4 ± 9.3μm. The normative values of Smax, Imax, Smax/Imax, Smax/Tavg, Imax/Tavg, Smax/Navg, Max-Min were 174.9 ± 19.7, 184.6 ± 20.3, 0.96 ± 0.14, 2.16 ± 0.37, 2.27 ± 0.34, 2.44 ± 0.52, 143.1 ± 19.4μm, respectively. The coefficient of variation (%) of the RNFLT parameters of clock type (1-12) of normal subjects whose ages ranged from 5 to 40 years old were 19.06, 23.56, 20.33, 20.52, 17.80, 16.39, 13.72, 19.93, 16.01, 16.42, 12.63, and 18.06 , respectively. Those in the superior, nasal, inferior, temporal quadrant and the mean of whole circle were 11.84, 17.71, 11.26, 15.15, and 8.43, respectively. Some RNFLT parameters including 2, 3, 7, 10, N, T, and Smax/Tavg had statistically significant differences(t = 2.257-3.344, P = 0.025-0.001, P < 0.05), and the differences among the other 17 parameters were not statistically significant between different gender in the normal subjects whose ages ranged from 5 to 40 years old. Some RNFLT parameters including 4, 5, 6, 7, 9 o'clock, I, Smax, Imax, Smax/Imax, and Max-Min did not have statistically significant differences (t = 1.706-0.030, P = 0.091-0.976, P>0.05). The differences among the other 14 parameters were statistically significant (t = 2.242-4.478, P = 0.027-0.000, P < 0.05) between right eyes and left eyes of the normal subjects whose ages ranged from 5 to 40 years old. Some RNFLT parameters including 1, 4, 9, N, Imax, and Imax/Tavg had statistically significant differences (P < 0.05), and the differences among the other 18 parameters were not statistically significant (P> 0.05), between different groups according to age in the normal subjects whose ages ranged from 5 to 40 years old. The variation of the RNFLT parameters in the normal subjects was unequal. Among the 24 parameters, the variation of the Avg. Thickness is the least. Among the 12 clocks, the variation of 7 and 9 o'clock was the least. The variation of S and /was less than N in different quadrant, and the variation of Smax/Navg was greater than others in the remaining parameters. CONCLUSION: Some RNFLT parameters have statistically significant differences in the following factors: different gender, right or left eyes, groups according to age of the normal subjects whose ages ranged from 5 to 40 years old.


Chen R.-B.,The Third Hospital of Chinese PLA | Hou N.,The 451 Hospital of Chinese PLA | Wang R.,The Third Hospital of Chinese PLA | He M.,The Third Hospital of Chinese PLA | And 4 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2015

BACKGROUND: Total knee arthroplasty is the major treatment of rheumatoid arthritis at advanced stage. Most of scholars prefer the staging replacement and adopt semi-restricting prosthesis to increase the stability of prosthesis. OBJECTIVE: To investigate the clinical effect of synchronous total knee arthroplasty for treatment of bilateral knee rheumatoid arthritis. METHODS: From June 2011 to December 2013, 27 patients of knee rheumatoid arthritis were recruited from the First Department of Orthopedics at the Third Hospital of Chinese PLA, and were treated with total knee arthroplasty at the bilateral sides over the same period. According to the symptoms, functional recovery and imaging evaluation, postoperative effect was assessed. The involved patients were followed up at 2 weeks, 1 month, 3 months, 6 months after surgery and afterwards once per year. The relief of pain symptoms, recovery of joint function, X-ray examination, loosening and sink of the prosthesis were observed during follow-ups. RESULTS AND CONCLUSION: All the patients were followed up over a period of 9-26 months. After operation the pain disappeared, preoperative flexion and varus valgus deformity were corrected, limb walking function recovered well. The Hospital for Special Surgery scores was average 31.8 points before operation and increased to average 82.7 points after operation. There was no infection, lower limb deep vein thrombosis, loosening and sink of the prosthesis. Simultaneous total knee arthroplasty at the bilateral sides is a safe, effective operation method in the treatment of bilateral knee rheumatoid arthritis, with short recovery time and hospitalization period, it can avoid psychological and economic impact of the two single knee replacement operations to the patients. © 2015, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.


PubMed | the Third Hospital of Chinese PLA
Type: Journal Article | Journal: International journal of ophthalmology | Year: 2012

To compare the effect of propofol versus urapidil on hemodynamics and intraocular pressure during anesthesia and extubation for ophthalmic patients.Eighty-two surgical patients (Class: ASA I-II) were randomly assigned to propofol (n=41) and urapidil groups (n=41). Their gender, age, body mass, operation time and dosage of anesthetics had no significant difference between the two groups (P>0.05). The patients of propofol and urapidil groups were given propofol (1.5mg/kg) and urapidil (2.5mg/kg) respectively; and two drugs were all diluted with normal saline to 8mL. Then the drugs were given to patients by slow intravenous injection. After treatment, the patients were conducted immediate suction, tracheal extubation, and then patients wore oxygen masks for 10 minutes. By double-blind methods, before the induction medication, at the suction, and 5, 10 minutes after the extubation, we recorded the systolic and diastolic blood pressure (BP), heart rate (HR), pH, PaO(2), PaCO(2), SaO(2) and intraocular pressure (IOP) respectively. The complete recovery time of the patients with restlessness (on the command they could open eyes and shaking hands) was also recorded during the extubation. The data were analyzed by using a professional SPSS 15.0 statistical software.The incidence of cough, restlessness and glossocoma was significantly lower in the propofol group than that in the urapidil group after extubation (P<0.05). There were no episodes of hypotension, laryngospasm, or severe respiratory depression. There was no statistical difference in recovery time between two groups (P>0.05). In propofol group, the BP and HR during extubation and thereafter had no significant difference compared with those before induction, while they were significantly lower than those before giving propofol (P<0.05), and had significant difference compared with those in urapidil group (P<0.05). Compared to preinduction, the BP of urapidil group showed no obvious increase during aspiration and extubation. The HR of urapidil group had little changes after being given urapidil, and it was obviously increased compared with that before induction. The stimulation of aspiration and extubation caused less cough and agitation in propofol group than that in urapidil group (P<0.05). The IOP of propofol group showed no obvious increase during extubation compared with that in preinduction, while in the urpidil group, extubation caused IOP significantly increased (P<0.05). The changes in these indicators between the two groups had no significant difference (P>0.05).Compared to urapidil, propofol is superior for preventing the cardiovascular and stress responses and IOP increases during emergence and extubation for the ophthalmic patients. Moreover, it has no effects on patients recovery.

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