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Zhuang S.,The Second Affiliated Hospital to Nan Chang University | Zhuang S.,The Third Affiliated Hospital of Sun Yat Sun University | Ye J.,The Third Affiliated Hospital of Sun Yat Sun University | Li J.,The Third Affiliated Hospital of Sun Yat Sun University
BMC Pediatrics | Year: 2015

Background: Acute spontaneous neck haematoma is rare in children. This rare type of hematoma occurs abruptly without any preceding trauma or iatrogenic damage, making it very difficult to determine the cause precisely. We report here the first two cases of acute spontaneous neck haematoma presenting with neck swelling, and discuss in this article the diagnosis and treatment strategy in our patients. Case presentation: We report a 19-month-old girl and a 30 month-old boy with neck swelling for 10 days. There was no history of trauma, cough, excessive muscular strain or iatrogenic injury, and both patients were not on any anticoagulants or antiplatelet drugs. On initial examination, the swelling was tender, firm and not mobile on palpation. A definite diagnosis was made by hematoma puncture. Both of the haematoma resolved spontaneously in two weeks without any complications or sequelae. Conclusions: Acute spontaneous neck hematoma in children is a rare disorder without any etiology or precipitating factors. The difficulty in making an early diagnosis is mainly due to the nonspecific presenting symptoms. Conservative management and follow-up is recommended as a choice of treatment. © Zhuang et al.; licensee BioMed Central. Source


Xue-Kun H.,The Third Affiliated Hospital of Sun Yat Sun University | Yuan L.,The Third Affiliated Hospital of Sun Yat Sun University | Jin Y.,The Third Affiliated Hospital of Sun Yat Sun University | Peng L.,The Third Affiliated Hospital of Sun Yat Sun University | Hong L.,The Third Affiliated Hospital of Sun Yat Sun University
Scientific Research and Essays | Year: 2010

This study investigated the expression of MUC2 and MUC5B in the ethmoid sinus mucosa of patients with chronic rhinosinusitis (CRS). Immunohistochemistry and fluorescence quantitative reverse transcription polymerase chain reaction (RT-PCR) were performed to detect the expression of MUC2 and MUC5B in the ethmoid sinus mucosa of 32 patients with CRS and 7 control individuals. Immunohistochemistry confirmed the expression of MUC2 and MUC5B in the ethmoid sinus mucosa of both patients and control subjects, and the expression of both proteins in CRS patients was significantly higher than that in control individuals (p < 0.01). The mRNA expression of MUC2 and MUC5B was 10.55 ± 3.91 × 104 and 18.80 ± 15.68 × 105 copies/μg in CRS patients, and 1.36 ± 0.46 × 104 copies/μg and 1.49 ± 0.46 × 105 copies/μg in control individuals, respectively, with significant differences between the two groups (p < 0.01). Statistical analysis demonstrated the markedly increased expression of MUC2 and MUC5B in the ethmoid sinus mucosa of CRS patients, when compared with control individuals. The expression MUC2 and MUC5B in the ethmoid sinus mucosa of CRS patients was up-regulated, and the up-regulated expression may result in mucus hypersecretion and compromised mucociliary clearance in CRS patients. © 2010 Academic Journals. Source

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