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Yan Q.,The State Key Laboratory Breeding Base of Basic Science of Stomatology Hubei MOST and Key Laboratory for Oral Biomedical Ministry of EducationSchool and Hospital of Stomatology | Xiao L.-Q.,Chongqing Three Gorges University | Sun W.,The State Key Laboratory Breeding Base of Basic Science of Stomatology Hubei MOST and Key Laboratory for Oral Biomedical Ministry of EducationSchool and Hospital of Stomatology | Wu T.,The State Key Laboratory Breeding Base of Basic Science of Stomatology Hubei MOST and Key Laboratory for Oral Biomedical Ministry of EducationSchool and Hospital of Stomatology | And 3 more authors.
Journal of Biomedical Materials Research - Part A | Year: 2015

Reports on the local delivery of drug loaded injectable hydrogels for bone regeneration are currently limited. This study assessed the effect of controlled simvastatin (SIM) release from a thermo-sensitive hydrogel in vitro and in vivo. We successfully manufactured and evaluated thermo-sensitive poly(d,l-lactide-co-glycolide)-poly(ethylene glycol)-poly(d,l-lactide-co-glycolide) triblock copolymers (PLGA-PEG-PLGA) loaded with SIM. The osteogenic effect of this hydrogel was tested in vitro and in vivo. MC-3T3 E1 cells proliferation and osteoblastic differentiation was analyzed after cultivation with the hydrogel extracts. Cells co-cultured with SIM/PLGA-PEG-PLGA extracts showed an increase in mineralization and osteogenic gene expression compared to the other two groups. Additionally, the characteristics of this composite in vivo were demonstrated using a rat bone defect model. The bone defects injected with SIM/PLGA-PEG-PLGA hydrogel showed increased new bone formation compared to samples treated with PLGA-PEG-PLGA and control samples. The results of this study suggest that SIM/PLGA-PEG-PLGA might provide potential therapeutic value for bone healing. © 2015 Wiley Periodicals, Inc. Source

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