The Second University of Naples is a university located in Caserta, Naples and other cities of the province of Caserta. .It was founded in 1991 and is organized into departments and Specialist Schools.The registered office is located in the city of Caserta.Despite having Naples in its name and some facilities in that city, it mainly developed in the territory of the province of Caserta particularly, including Caserta itself, Aversa, Capua, Marcianise, Santa Maria Capua Vetere. The law of institution, of 1989, qualified this area as "metropolitan district of Naples".The most ancient school, the one of Medicine and surgery, is located in Naples, where is situated the historical seat of the rector. Wikipedia.
Cacciapuoti F.,The Second University of Naples
Journal of Thrombosis and Thrombolysis | Year: 2011
Increased homocysteine levels can be responsible for arterial ischemic events, such as MI, stroke or peripheral vascular disease. Homocysteine is metabolized by two pathways: re-methylation and trans-sulfuration. Both involve folic acid, and vitamins B6-12. Several studies assumed that the folates and vitamins B supplementation or dietary source to normalize plasma homocysteine. But, even if tends to normalize homocysteine levels, lowering homocysteine by B-group vitamins and/or folates does not reduce cardiovascular risk. In fact, recent reports confirmed that hyper-homocysteinemia is not directly responsible for cardiovascular disease, but is merely present in individuals suffering for acute and/or chronic cardiovascular events, as a collateral finding. Reduced methylation potential (MP) [due to decreased S-adenosyl-methionine (AdoMet)/Sadenosyl- homocysteine (AdoHcy) ratio] induced by the elevated plasma homocysteine levels seems to be the true responsible for cardiovascular diseases (CVD). The pathogenic mechanisms responsible for CVD appear to be dependent of DNA hypomethylation inducing an inhibition of cyclin A transcription and a reduction of endothelial cells growth. But, other human studies performed in a wide range are requested. © Springer Science+Business Media, LLC 2011.
Rocco M.,The Second University of Naples
Journal of proteome research | Year: 2011
During the last few years, the incidence and mortality of human melanoma have rapidly increased. Metastatic spread of malignant melanoma is often associated with cancer progression with poor prognosis and survival. These processes are controlled by dynamic interactions between tumor melanocytes and neighboring stromal cells, whose deregulation leads to the acquisition of cell proliferation capabilities and invasiveness. It is increasingly clear that a key role in carcinogenesis is played by secreted molecules either by tumor and surrounding stromal cells. To address the issue of the proteins secreted during cancer progression, the proteomic profiling of secretomes of cancer cell lines from different melanoma metastases of the same patient (PE-MEL-41, PE-MEL-47, and PE-MEL-43) was performed by applying a shotgun LC-MS/MS-based approach. The results provide a list of candidate proteins associated with the metastatic potential of PE-MEL melanoma cell lines. Among them, several matricellular proteins previously reported as involved in melanoma aggressiveness were identified (i.e., SPARC, osteopontin). In addition, the extracellular matrix protein 1 that stimulates proliferation and angiogenesis of endothelial cells as well as the fibronectin, involved in cell adhesion and motility, were identified. The present work provides the basis to clarify the complex extracellular protein networks implicated in human melanoma cell invasion, migration, and motility.
Minale M.,The Second University of Naples
Physics of Fluids | Year: 2014
The momentum balance on the solid skeleton of a porous medium like porous rocks, foam metals, or porous brushes is, here, theoretically derived with the volume averaging method. It is derived for both homogeneous and non-homogeneous porous media and for the latters no length scales constraints are invoked. The momentum balance on the solid skeleton holds in the whole porous medium and contains volume averaged stresses and velocity. For heterogeneous porous media, it is coupled with the fluid momentum balance through a general averaged quantity, while in the homogeneous case, it is coupled with Darcy's equation, corrected with the first and the second Brinkman's term, through a geometrically rescaled Darcy's term. This latter equation coincides with Biot's equation for poro-elasticity, but it is here derived with a different formalism. This approach gives the opportunity to derive a new stress boundary condition at the interface between a porous medium and a homogeneous fluid. © 2014 AIP Publishing LLC.
Minale M.,The Second University of Naples
Physics of Fluids | Year: 2014
In this paper, we derive a boundary condition at the interface between a free fluid and a porous medium stating that the stress is transferred both to the fluid within the porous medium and to the solid skeleton. A zero stress jump is obtained so that the total stress is preserved at the interface. The boundary condition is obtained with the volume averaging method following the approach of Ochoa-Tapia and Whitaker ["Momentum transfer at the boundary between a porous medium and a homogeneous fluid-I. Theoretical development," Int. J. Heat Mass Transfer 38(14), 2635-2646 (1995)], but starting from the momentum balances written on the fluid and on the solid of the porous region, the latter was derived in part I of this paper. In the same way, also the boundary condition at the interface between a porous medium and a homogeneous solid is obtained. Both boundary conditions describe the equilibrium of forces at the interface, where part of the stress is carried by the solid skeleton and part by the fluid within the porous medium. With the derived boundary conditions, together with the stress transfer equation within the solid skeleton, it is now possible to satisfy the overall force equilibrium on a shear cell partially filled with a porous medium. © 2014 AIP Publishing LLC.
Palmieri F.,The Second University of Naples
Future Generation Computer Systems | Year: 2013
The diffusion of ubiquitous and pervasive computing applications, providing advanced services anytime and everywhere across heterogeneous mobile networks, is fostering the development of new architectures and models, based on the emerging peer-to-peer paradigm, to allow the effective use of multiple replicated resources and services without the scalability and adaptiveness limitations characterizing traditional client-server organizations. In this scenario, effective service discovery facilities are needed to minimize the administrative overhead and increase the overall usability and perceived service quality. However, most of the currently available implementations lack efficiency due to the highly dynamic and hierarchically flat nature of the underlying wireless mobile networking environment, that make any traditional solution based on centralized schemes and statically defined roles practically unfeasible. Accordingly we proposed a novel service discovery approach based on a fully distributed and parallel search model, that does not require any centralized intelligence, fixed roles and stable communication infrastructure. It exploits, in a dynamic scale-free scenario characterized by competition for links and balanced node insertion and removal rates, a widely known random walk-based search paradigm benefitting from bond percolation in power law organizations to automatically limit the search space (by shielding low connectivity nodes from search traffic) and drastically reduce the total control overhead. We analyzed the effectiveness and performance of the proposed solution by using discrete event-driven simulation, whose results were satisfactory also in highly mobile ad-hoc environments. This indicates that the proposed ideas are promising and deserve further exploitation by practical application solutions designers. © 2012 Elsevier B.V. All rights reserved.