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Li G.-w.,The Second Peoples Hospital of Zhengzhou
Chinese Journal of Tissue Engineering Research | Year: 2012

BACKGROUND: Application of total knee arthroplasty (TKA) for knee valgus deformity can be difficult technically in many aspects and exist a lot of controversy. OBJECTIVE: To investigate the clinical efficiency and surgical methods of TKA for knee valgus deformity in the adults. METHODS: Totally 15 knees from 12 patients underwent patellar lateral approach for proper osteotomy and selective lysis of the soft tissue to regain normal biomechanics and soft tissue balance of knee were selected. Posterior stabilized prosthesis was used for TKA to obtain the stability of the knee. After the surgery, rehabilitation therapy pertinently was adopted. Before and after the surgery, tibiofemoral angle was measured. Range of motion (ROM) was examined and HSS score was evaluated. RESULTS AND CONCLUSION: All patients were followed up over 6 months. Tibiofemoral angle decreased from 21.47° preoperatively to 5.47° postoperatively (P < 0.01). The ROM increased from 81.33° preoperatively to 121.07° postoperatively (P < 0.01). HSS score improved from 25.47 preoperatively to 89.87 postoperatively (P < 0.01). After replacement, 1 case affected more joint effusion, 2 cases affected knee instability. There was no dislocation or subluxation of the patella. Force line of lower limb returned to normal. TKA can effectively correct the knee valgus deformity, and can significantly improve the function of the knee. Source


Wan X.-H.,Capital Medical University | Li X.-X.,The Second Peoples Hospital of Zhengzhou
Ophthalmology in China | Year: 2014

Posterior capsular opacification (PCO) is the most common complication after cataract operation. Recently, there are many researches interested in how to prevent PCO, such as the developments in the intraocular lens materials and designs, surgical methods such as anterior capsule polishing, posterior capsulorhexis with anterior vitrectomy, implanting capsular tension ring (CTR) or capsular adhesion-preventing ring (CAPR). However, the most of these preventing methods are controversial, the most action mechanisms are still unclear, and the long time effects are still uncertain. Copyright © 2014 by the Editorial Board of OPHTHALMOLOGY IN CHINA. Source


Wang Z.L.,Henan Eye Institute | di Qiao B.,The Second Peoples Hospital of Zhengzhou | Li G.X.,Wenzhou University | Li S.Q.,Henan Eye Institute | And 2 more authors.
Central European Journal of Biology | Year: 2014

AMD is the main cause of visual impairment in people over 50 years of age and the most common cause of blindness. In recent years, the use of bevacizumab to treat neovascular AMD has become a preferred treatment in the United States. However, whether bevacozumab is available for RPE or AMD patients is unknown. We firstly indicate that Pam3CSK4 (P3C) activates TLR2 pathway during ARPE-19 apoptosis as determined by western blotting. And then, the expression of MyD88, NF-κB, p-IKK in primary RPE cells from AMD patients is significantly down-regulated after treatment with 50 μg L-1 Bevacizumab. Therefore, our data shows that MyD88 is involved in the TLR2 pathway in ARPE-19 cell apoptosis resulting from Pam3CSK4 (P3C). And more importantly, our findings suggested that Bevacizumab cured age-related macular degeneration (AMD) via down-regulate Toll-like receptor 2 (TLR2) pathway in RPE from AMD patients. © 2014 Versita Warsaw and Springer-Verlag Wien. Source


Li J.,The Second Peoples Hospital of Zhengzhou
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2012

To investigate the effectiveness and surgical skills of microsurgical repair of radial nerve deep branch injury. Between March 2001 and February 2011, 49 cases of radial nerve deep branch injury were treated by microsurgical technique. There were 40 males and 9 females with an average age of 32 years (range, 19-58 years), including 13 cases of knife-cut injury, 9 cases of electric-saw injury, 7 cases of dagger-stab injury, 6 cases of glass-cut injury, 5 cases of iatrogenic injury, 4 cases of Monteggia fracture, 3 cases of nailgun injury, and 2 cases of crush injury of the forearm complicated by fracture of the proximal radius. The disease duration ranged from 3 hours to 3 years and 8 months (mean, 4.9 months). The sites of injury were at front of supinator tube in 15 cases, in the supinator tube in 23 cases, and at back of supinator tube in 11 cases. One-stage repair was performed by end-to-end suture in 21 cases, including 9 cases of epineurial neurorrhaphy and 12 cases of perineurial neurorrhaphy; two-stage repair was performed in 28 cases, including 26 cases of sural nerve graft and 2 cases of neurolysis. Postoperative wounds primarily healed. All patients were followed up 21.5 months on average (range, 12-39 months). At last follow-up, in 21 cases of one-stage repair, the muscle strength of the extensor pollicis longus was level 5 in 13 cases, and level 4 in 8 cases; in 28 cases of two-stage repair, the muscle strength of the extensor pollicis longus was level 5 in 2 cases, level 4 in 21 cases, level 3 in 4 cases, and level 2 in 1 case; and significant difference was found (Z=-5.340, P=0.000). In 9 cases undergoing epineurial neurorrhaphy at one-stage repair, the muscle strength of the extensor pollicis longus was level 5 in 3 cases, and level 4 in 6 cases; in 12 cases undergoing perineurial neurorrhaphy at one-stage repair, the muscle strength of the extensor pollicis longus was level 5 in 10 cases, and level 4 in 2 cases; and significant difference was found (Z=-2.279, P=0.023). In 26 cases undergoing nerve graft at two-stage repair, the muscle strength of the extensor pollicis longus was level 5 in 2 cases, level 4 in 20 cases, level 3 in 3 cases, and level 2 in 1 case; in 2 cases undergoing neurolysis at two-stage repair, the muscle strength of the extensor pollicis longus was level 4 in 1 case and level 3 in 1 case; and no significant difference was found (Z=-1.117, P=0.264). According to the upper arm function assessment criterion issued by Hand Surgery Association of Chinese Medicine Association, the results were excellent in 18 cases, good in 3 cases in one-stage repair patients; excellent in 2 cases, good in 21 cases, fair in 4 cases, and poor in 1 case in two-stage repair patients; and there was significant difference (Z=-5.340, P=0.000). Microsurgical one-stage repair of radial nerve deep branch injury can obtain better effectiveness than two-stage repair by nerve graft, and perineurial neurorrhaphy is significantly better than epineurial neurorrhaphy. Source


Li G.-W.,The Second Peoples Hospital of Zhengzhou | Wang H.-J.,The Second Peoples Hospital of Zhengzhou | Sun X.-Z.,The Second Peoples Hospital of Zhengzhou
Chinese Journal of Tissue Engineering Research | Year: 2013

Background: Total knee arthroplasty used for the treatment of knee joint deformity is difficult and involves multi-aspects, including the surgical approach, intraoperative osteotomy, order, method and extent of soft tissue release and soft tissue balance, There are a lot of controversies due to different scholarly opinions. Objective: To explore the surgical methods and clinical efficacy of total knee arthroplasty for the treatment of severe knee disease. Methods: A total of 42 cases (48 knees) with severe knee disease and knee joint deformity were selected, and all the patients were treated with total knee arthroplasty using posterior stabilized prosthesis. Through patellar medial approach and correct osteotomy, selective soft tissue release was performed to restore normal knee alignment and soft tissue balance to harvest knee stability. The targeted rehabilitation training was performed after replacement and the knee range of motion and maximum knee flex degree were detected regularly. The Hospital for Special Surgery score and the Western Ontario and Mcmaster Universities Arthritis Index score were performed. Results and Conclusion: All patients were followed-up for 25 to 84 months, 35.5 months in average. The knee range of motion, maximum knee flex degree, Hospital for Special Surgery score and the Western Ontario and Mcmaster Universities Arthritis Index score of all the patients were significantly increased after replacement compared with those before replacement (P < 0.01). The wound was in stage I recovery. No knee joint rigidity, blood vessel and nerve injury, patella fracture, patella low-site and prosthesis loosening were observed after replacement. The lower limb alignment was restored to normal level. The adult severe knee deformity can be corrected through total knee arthroplasty, and the function is improved significantly with satisfactory clinical results. Source

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