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Li G.-W.,The Second Peoples Hospital of Zhengzhou | Wang H.-J.,The Second Peoples Hospital of Zhengzhou | Sun X.-Z.,The Second Peoples Hospital of Zhengzhou
Chinese Journal of Tissue Engineering Research | Year: 2013

Background: Total knee arthroplasty used for the treatment of knee joint deformity is difficult and involves multi-aspects, including the surgical approach, intraoperative osteotomy, order, method and extent of soft tissue release and soft tissue balance, There are a lot of controversies due to different scholarly opinions. Objective: To explore the surgical methods and clinical efficacy of total knee arthroplasty for the treatment of severe knee disease. Methods: A total of 42 cases (48 knees) with severe knee disease and knee joint deformity were selected, and all the patients were treated with total knee arthroplasty using posterior stabilized prosthesis. Through patellar medial approach and correct osteotomy, selective soft tissue release was performed to restore normal knee alignment and soft tissue balance to harvest knee stability. The targeted rehabilitation training was performed after replacement and the knee range of motion and maximum knee flex degree were detected regularly. The Hospital for Special Surgery score and the Western Ontario and Mcmaster Universities Arthritis Index score were performed. Results and Conclusion: All patients were followed-up for 25 to 84 months, 35.5 months in average. The knee range of motion, maximum knee flex degree, Hospital for Special Surgery score and the Western Ontario and Mcmaster Universities Arthritis Index score of all the patients were significantly increased after replacement compared with those before replacement (P < 0.01). The wound was in stage I recovery. No knee joint rigidity, blood vessel and nerve injury, patella fracture, patella low-site and prosthesis loosening were observed after replacement. The lower limb alignment was restored to normal level. The adult severe knee deformity can be corrected through total knee arthroplasty, and the function is improved significantly with satisfactory clinical results.


Li G.-W.,Zhengzhou University | Li G.-W.,The Second Peoples Hospital of Zhengzhou
Chinese Journal of Tissue Engineering Research | Year: 2013

BACKGROUND: Applying artificial hip joint replacement for the treatment of end-stage hip disease is difficult and involves multi-aspects, including the surgical approach, intraoperative osteotomy, prosthesis implantation and selection of type, There are a lot of controversies due to different scholarly opinions. OBJECTIVE: To explore the methods and clinical effects of the artificial hip joint replacement in the treatment of end-stage hip disease. METHODS: Retrospective analysis of 52 patients (57 hips) receiving artificial hip joint replacement was performed based on a long-term follow-up. The follow-up time was 14-86 months, 27 months in average. The preoperative and postoperative (last follow-up) visual analogue scale score and Harris hip score were recorded, analyzed and compared, and the results were statistically analyzed. RESULTS AND CONCLUSION: The visual analogue scale score in 52 patients was decreased from preoperative (7.0±1.2) points to postoperative (2.0±0.7) points. Harris score was increased from preoperative (35.9±5.4) points to the last follow-up (89.7±3.1) points. The difference was statistically significant when compared with that before operation (P < 0.05). All the 52 patients after surgery could walk with crutches or walker ambulation, and all of them could be able to walk independently and take self-care after 3 months. X-ray assessment showed no loosening of the prosthesis, and achieved satisfactory results. Careful preoperative preparation and scientific and rigorous operation can prevent the hip prosthesis loosening, infection and pain after operation. Rehabilitation exercise after surgery is an important measure to reduce the postoperative pain and recover the function to the maximum extent.


Wan X.-H.,Capital Medical University | Li X.-X.,The Second Peoples Hospital of Zhengzhou
Ophthalmology in China | Year: 2014

Posterior capsular opacification (PCO) is the most common complication after cataract operation. Recently, there are many researches interested in how to prevent PCO, such as the developments in the intraocular lens materials and designs, surgical methods such as anterior capsule polishing, posterior capsulorhexis with anterior vitrectomy, implanting capsular tension ring (CTR) or capsular adhesion-preventing ring (CAPR). However, the most of these preventing methods are controversial, the most action mechanisms are still unclear, and the long time effects are still uncertain. Copyright © 2014 by the Editorial Board of OPHTHALMOLOGY IN CHINA.


Li G.-w.,The Second Peoples Hospital of Zhengzhou
Chinese Journal of Tissue Engineering Research | Year: 2012

BACKGROUND: Application of total knee arthroplasty (TKA) for knee valgus deformity can be difficult technically in many aspects and exist a lot of controversy. OBJECTIVE: To investigate the clinical efficiency and surgical methods of TKA for knee valgus deformity in the adults. METHODS: Totally 15 knees from 12 patients underwent patellar lateral approach for proper osteotomy and selective lysis of the soft tissue to regain normal biomechanics and soft tissue balance of knee were selected. Posterior stabilized prosthesis was used for TKA to obtain the stability of the knee. After the surgery, rehabilitation therapy pertinently was adopted. Before and after the surgery, tibiofemoral angle was measured. Range of motion (ROM) was examined and HSS score was evaluated. RESULTS AND CONCLUSION: All patients were followed up over 6 months. Tibiofemoral angle decreased from 21.47° preoperatively to 5.47° postoperatively (P < 0.01). The ROM increased from 81.33° preoperatively to 121.07° postoperatively (P < 0.01). HSS score improved from 25.47 preoperatively to 89.87 postoperatively (P < 0.01). After replacement, 1 case affected more joint effusion, 2 cases affected knee instability. There was no dislocation or subluxation of the patella. Force line of lower limb returned to normal. TKA can effectively correct the knee valgus deformity, and can significantly improve the function of the knee.


Feng K.,The Second Peoples Hospital of Zhengzhou | Chen P.,The Second Peoples Hospital of Zhengzhou | Kong Y.,The Second Peoples Hospital of Zhengzhou | Yuan J.,The Second Peoples Hospital of Zhengzhou
International Journal of Ophthalmology | Year: 2011

Conjunctival papilloma is a benign and epithelial tumour, it can be classified into conjunctiva type and limbus type depending on its site. Compared to the limbus type which is common in middle-aged people the conjunctiva type which usually occurs in children or adolesents is more common. The hyperplasia of conjunctival papilloma may leads to conjunctival squamous cell carcinoma. Conjunctival papilloma can be of viral origin(human papilloma virus, HPV), which is also related to conjunctival squamous cell carcinoma, so it is very important to detect HPV in patients for treatment and follow-up. The common treatment of conjunctival papilloma is sugical excision, but simple treatment is associated with high recurrence rate. Several types of therapy have been described, including liquid nitrogen cryotherapy, cauterization, cytotoxic drug and interferon. We report a case of recurrent limbus-based papilloma treated successfully with combined therapy.


Qian L.,Zhengzhou University | Qian L.,The Second Peoples Hospital Of Zhengzhou | Zhao H.,The Second Peoples Hospital Of Zhengzhou | Li X.,The Second Peoples Hospital Of Zhengzhou | And 5 more authors.
Cell Biochemistry and Biophysics | Year: 2015

In this study, we investigated the effects and mechanism of action of pirenzepine in a guinea pig model of myopia induced by exposure to monochromatic light. It was observed that pirenzepine inhibited the increase of diopter and extension of ocular axial length. Immunohistochemistry staining showed that the number of tyrosine hydroxylase (TH)-positive cells in pirenzepine group was significantly higher compared to the other treatment groups pointing to a highly positive correlation between TH expression levels and the diopter and axial length change. RT-PCR analysis further showed that pirenzepine treatment reduced the expression of matrix metalloproteinase (MMP-2) and enhanced the expression of tissue inhibitors of metalloproteinase (TIMP-2) compared to the other treatment and control groups. To conclude, we demonstrate that pirenzepine may improve the prognosis of monochromatic light-induced myopia in guinea pigs, possibly by both regulating the balance of MMP-2 and TIMP-2 in sclera and increasing the TH expression in retina. © 2014, Springer Science+Business Media New York.


Li J.,the Second Peoples Hospital of Zhengzhou
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2012

To investigate the effectiveness and surgical skills of microsurgical repair of radial nerve deep branch injury. Between March 2001 and February 2011, 49 cases of radial nerve deep branch injury were treated by microsurgical technique. There were 40 males and 9 females with an average age of 32 years (range, 19-58 years), including 13 cases of knife-cut injury, 9 cases of electric-saw injury, 7 cases of dagger-stab injury, 6 cases of glass-cut injury, 5 cases of iatrogenic injury, 4 cases of Monteggia fracture, 3 cases of nailgun injury, and 2 cases of crush injury of the forearm complicated by fracture of the proximal radius. The disease duration ranged from 3 hours to 3 years and 8 months (mean, 4.9 months). The sites of injury were at front of supinator tube in 15 cases, in the supinator tube in 23 cases, and at back of supinator tube in 11 cases. One-stage repair was performed by end-to-end suture in 21 cases, including 9 cases of epineurial neurorrhaphy and 12 cases of perineurial neurorrhaphy; two-stage repair was performed in 28 cases, including 26 cases of sural nerve graft and 2 cases of neurolysis. Postoperative wounds primarily healed. All patients were followed up 21.5 months on average (range, 12-39 months). At last follow-up, in 21 cases of one-stage repair, the muscle strength of the extensor pollicis longus was level 5 in 13 cases, and level 4 in 8 cases; in 28 cases of two-stage repair, the muscle strength of the extensor pollicis longus was level 5 in 2 cases, level 4 in 21 cases, level 3 in 4 cases, and level 2 in 1 case; and significant difference was found (Z=-5.340, P=0.000). In 9 cases undergoing epineurial neurorrhaphy at one-stage repair, the muscle strength of the extensor pollicis longus was level 5 in 3 cases, and level 4 in 6 cases; in 12 cases undergoing perineurial neurorrhaphy at one-stage repair, the muscle strength of the extensor pollicis longus was level 5 in 10 cases, and level 4 in 2 cases; and significant difference was found (Z=-2.279, P=0.023). In 26 cases undergoing nerve graft at two-stage repair, the muscle strength of the extensor pollicis longus was level 5 in 2 cases, level 4 in 20 cases, level 3 in 3 cases, and level 2 in 1 case; in 2 cases undergoing neurolysis at two-stage repair, the muscle strength of the extensor pollicis longus was level 4 in 1 case and level 3 in 1 case; and no significant difference was found (Z=-1.117, P=0.264). According to the upper arm function assessment criterion issued by Hand Surgery Association of Chinese Medicine Association, the results were excellent in 18 cases, good in 3 cases in one-stage repair patients; excellent in 2 cases, good in 21 cases, fair in 4 cases, and poor in 1 case in two-stage repair patients; and there was significant difference (Z=-5.340, P=0.000). Microsurgical one-stage repair of radial nerve deep branch injury can obtain better effectiveness than two-stage repair by nerve graft, and perineurial neurorrhaphy is significantly better than epineurial neurorrhaphy.


PubMed | The Second Peoples Hospital of Zhengzhou
Type: Journal Article | Journal: Eye science | Year: 2014

To investigate the clinical significance of 24-hour monitoring of intraocular pressure (IOP).A total of 571 cases (1055 eyes) undergoing 24-hour monitoring of IOP in the Second Peoples Hospital of Zhengzhou between June 2012 and March 2013 were retrospectively analyzed.Among all 1055 eyes, 298 had suspected glaucoma (28.2%); 390 (37.0%) were diagnosed with glaucoma but received no treatment (312 with primary open angle glaucoma (POAG) and 78 with primary angle closure glaucoma (PACG)); 215 (20.4%) were diagnosed with glaucoma and received medical treatment; 132 (12.5%) underwent glaucoma filtration surgery; and there were 20 others. Through 24-hour IOP monitoring, 104 among 298 cases with suspected glaucoma were diagnosed with normal tension glaucoma (NTG), 110 with POAG, and 28 with the secondary glaucoma. Condition assessment and treatment plans were presented for 390 glaucoma cases receiving no treatment. Adjustment was made in the medical treatment of 138 eyes. Following glaucoma filtration surgery, 52 eyes received clinical advice on subsequent treatment.The simplified 24-hour IOP monitoring method is readily accepted by patients, which is of great significance for providing guidance on the diagnosis of glaucoma and the assessment of the efficacy of glaucoma surgery. However, one-time 24-hour IOP monitoring is not sufficiently efficacious to make a definite diagnosis of NTG. Therefore, long-term follow-up and repeated 24-hour IOP monitoring are required to diagnose NTG, along with a variety of related examinations.


PubMed | Zhengzhou University and The Second Peoples Hospital of Zhengzhou
Type: Journal Article | Journal: Cell biochemistry and biophysics | Year: 2016

In this study, we investigated the effects and mechanism of action of pirenzepine in a guinea pig model of myopia induced by exposure to monochromatic light. It was observed that pirenzepine inhibited the increase of diopter and extension of ocular axial length. Immunohistochemistry staining showed that the number of tyrosine hydroxylase (TH)-positive cells in pirenzepine group was significantly higher compared to the other treatment groups pointing to a highly positive correlation between TH expression levels and the diopter and axial length change. RT-PCR analysis further showed that pirenzepine treatment reduced the expression of matrix metalloproteinase (MMP-2) and enhanced the expression of tissue inhibitors of metalloproteinase (TIMP-2) compared to the other treatment and control groups. To conclude, we demonstrate that pirenzepine may improve the prognosis of monochromatic light-induced myopia in guinea pigs, possibly by both regulating the balance of MMP-2 and TIMP-2 in sclera and increasing the TH expression in retina.


PubMed | Nanchang University, the Second Peoples Hospital of Zhengzhou and University of Jinan
Type: Journal Article | Journal: PloS one | Year: 2015

Oculocutaneous albinism (OCA) is an autosomal recessive disorder. The most common type OCA1 and OCA2 are caused by homozygous or compound heterozygous mutations in the tyrosinase gene (TYR) and OCA2 gene, respectively.The purpose of this study was to evaluate the molecular basis of oculocutaneous albinism in four Chinese families.Four non-consanguineous OCA families were included in the study. The TYR and OCA2 genes of all individuals were amplified by polymerase chain reaction (PCR), sequenced and compared with a reference database.Four patients with a diagnosis of oculocutaneous albinism, presented with milky skin, white or light brown hair and nystagmus. Genetic analyses demonstrated that patient A was compound heterozygous for c.1037-7T.A, c.1037-10_11delTT and c.1114delG mutations in the TYR gene; patient B was heterozygous for c.593C>T and c.1426A>G mutations in the OCA2 gene, patients C and D were compound heterozygous mutations in the TYR gene (c.549_550delGT and c.896G>A, c.832C>T and c.985T>C, respectively). The heterozygous c.549_550delGT and c.1114delG alleles in the TYR gene were two novel mutations. Interestingly, heterozygous members in these pedigrees who carried c.1114delG mutations in the TYR gene or c.1426A>G mutations in the OCA2 gene presented with blond or brown hair and pale skin, but no ocular disorders when they were born; the skin of these patients accumulated pigment over time and with sun exposure.This study expands the mutation spectrum of oculocutaneous albinism. It is the first time, to the best of our knowledge, to report that c.549_550delGT and c.1114delG mutations in the TYR gene were associated with OCA. The two mutations (c.1114delG in the TYR gene and c.1426A>G in the OCA2 gene) may be responsible for partial clinical manifestations of OCA.

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