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Xiong H.-H.,The Second Peoples Hospital of Shenzhen | Zhen J.-X.,Shenzhen Blood Center | Deng Z.-H.,Shenzhen Blood Center
Tissue Antigens | Year: 2014

KIR2DL3*030 differs from the closest allele, KIR2DL3*00101, by a single missense mutation at CDS. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Source


Li H.Y.,The Second Peoples Hospital of Shenzhen
Zhonghua nei ke za zhi [Chinese journal of internal medicine] | Year: 2010

To evaluate effects of glycemic control on refraction in diabetic patients. Twenty newly diagnosed diabetic patients were included in this study. The random blood glucose, glycosylated hemoglobin A1c (HbA1c) levels, fasting C-peptide and postprandial 2 h C-peptide levels were measured before treatment. The patients with random blood glucose ≥ 12.0 mmol/L and HbA1c ≥ 10.0% were selected. Refraction, intraocular pressure, radius of the anterior corneal curvature, depth of the anterior chamber, lens thickness, vitreous length, and axial length were measured on admission and at the end of week 1, 2, 3 and 4 during glycaemic control. A transient hyperopic change occurred in all the patients receiving glycemic control with a mean maximum hyperopic changes of 1.6 D (0.50 D ∼ 3.20 D). There was a positive correlation between the magnitude of the maximum hyperopic changes and the HbA1c levels on admission (r = 0.84, P < 0.05). There was a positive correlation between the magnitude of the maximum hyperopic changes and the daily rate of blood glucose reduction over the first 7 days of the treatment (r = 0.53, P < 0.05). There was no significant correlation between the magnitude of the maximum hyperopic changes and the levels of random blood glucose on admission. No significant correlation was observed between the maximum hyperopic changes and fasting C-peptide or postprandial 2 h C-peptide. There were no significant correlations between the magnitude of the maximum hyperopic changes and age, blood press, body mass index, triglyceride, total cholesterol, low-density lipoprotein or high-density lipoprotein. No significant changes were observed in the intraocular pressure, radius of the anterior corneal curvature, depth of the anterior chamber, lens thickness, vitreous length and axial length during glycemic control. Transient hyperopic changes occur after glycemic control in diabetic patients with severe hyperglycaemia. The degrees of transient hyperopia are highly dependent on HbA1c levels before treatment and the rate of reduction of glucose level over the first 7 days of treatment. This is probably due to the decrease of refractive power by lens hydration, not morphological change of lens. Source


Qiu X.X.,The Second Peoples Hospital of Shenzhen
Zhonghua nan ke xue = National journal of andrology | Year: 2012

To study the MRI manifestation of testicular tumor and the value of MRI in the diagnosis of the disease. We retrospectively analyzed 23 cases of pathologically confirmed testicular tumor, and observed the morphological characteristics, signals and surrounding conditions of the tumor using plain and enhanced MRI scanning. Of the 23 cases, seminoma was identified in 7, mixed germinoma in 3, teratoma in 3, endodermal sinus tumor in 2, epidermoid in 1, Leydig cell tumor in 1, leucoma in 1, nonspecific inflammatory mass in 3, and tuberculosis in 2. MRI revealed the precise locations and specific characteristics of Based on MRI findings and clinical manifestation, most testicular tumors can be diagnosed correctly. Source


Yang X.J.,The Second Peoples Hospital of Shenzhen
Nan fang yi ke da xue xue bao = Journal of Southern Medical University | Year: 2011

To investigate the feasibility of vibration test in evaluation of spinal stability after instrument fixation of thoracolumbar burst fracture in pigs. Twenty-one porcine spines (T11 to L5) were impacted longitudinally with different energy levels to simulate thoracolumbar burst fracture. The fractures were fixed by Luque, Harrington, Steffee and Kaneda techniques, and the anterior-posterior, lateral and vertical spinal stability was analyzed using vibration test. In the mild injury group, vibration test showed that only the first order frequency showed marked anterior shift in the vertical direction (P<0.05) but the main frequency did not, suggesting loosening between the vertebrae. In moderate- or high-energy impact groups, the main frequency markedly shifted forward in the vertical and anterior-posterior directions (P<0.05 or P<0.01), and obvious lateral shift was observed only in high-energy impact group. The dynamical characteristics of the spine indicate that the main frequency markedly shift after instrument fixation (except for Luque) of thoracolumbar burst fracture, suggesting the feasibility of vibration test for evaluating spinal injury severity and instrument fixation. Source


Li C.,CAS Institute of Biophysics | Wu S.,The Second Peoples Hospital of Shenzhen | Wang H.,The Second Affiliated Hospital of Kunming Medical College | Bi X.,Chinese Academy of Sciences | And 6 more authors.
Oncotarget | Year: 2015

Bladder cancer is one of the most common malignant tumors worldwide. Bladder cancer stem cells (BCSCs) have been isolated recently but have not been defined yet. Here we sorted BCSCs from bladder tumor tissues or normal bladder stem cells (NBBCs) from adjacent normal bladder tissues. We found that the C228T mutation (chr5, 1, 295, 228 C > T) of TERT promoter frequently occurs in BCSCs, but not exist in NBBCs. Importantly, introducing the C228T mutation in NBBCs causes TERT overexpression and transformation of bladder cancer. Restoration of the C228T mutation to T228C in BCSCs can recover the TERT expression to a basal level and abolish tumor formation. Additionally, the C228T mutation of TERT promoter triggers TERT expression leading to increased telomerase activity. TERT expression levels are consistent with clinical severity and prognosis of bladder cancer. Source

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