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Tang Z.-J.,Shanghai University | Huang Z.-P.,Nanjing General Hospital of Nanjing Military Command | Yang W.-J.,the Second Military Medical University | Zou Y.-X.,Shanghai University | Cai J.-P.,Shanghai University
International Eye Science | Year: 2014

AIM: To discuss Daidzein intravitreal injection whether has protective and recovery effects on acute nerve damages. METHODS: After the crush models of acute optic nerve were set up, 72 males SD rats were divided into 4 groups randomly as common group without surgery, FBS negative control group, Daidzein treatment group (10μmol/L, 100μmol/L, 1000μmol/L) and positive control group using rats nerve growth factor (mNGF, 100ng/mL). Three days after interference, all experimental animals were executed. HE staining was used to evaluate morphologic change of the retina, immunohisochemical staining and western-blot tests for identifying and quantifying the distinct expression of Caspase-3 and GAP-43 among the groups. RESULTS: Compared with the normal group and negative control group, retinal morphology of different concentrations of each Daidzein treatment group and positive control group was more complete, the expression of Caspase-3 protein was relatively lower, the expression of GAP-43 protein was relatively higher, the differences have statistically significance (P<0.05). CONCLUSION: Daizein injection in the vitreous cavity has the capacity of protection and restoration in rat's acute nerve damages. Source


Song X.-L.,Tongji University | Sun X.-Y.,the Second Military Medical University | Zhang G.-L.,Tongji University | Yu Y.-W.,Second Military Medical University | Wang C.-H.,Tongji University
Internal Medicine | Year: 2012

Myopericytoma is a benign tumor composed of cells that show apparent differentiation towards putative perivascular myoid cells called myopericytes. To date, only a small number of series describing myopericytomas have been reported. Here, we report a case of pulmonary myopericytoma presenting as multiple nodules in a 26-year-old man. Clinical presentation, radiological features and histopathologic findings of the patient are also discussed. The result of the histology combined with the immunohistochemical analysis led to a diagnosis of myopericytomas. To our knowledge, this is the first report of myopericytoma showing pulmonary involvement. © 2012 The Japanese Society of Internal Medicine. Source


Patent
Chinese Institute of Microbiology, Epidemiology and The Second Military Medical University | Date: 2014-05-19

The present invention discloses a class of mercaptonicotinic acid compound and preparation method and use thereof; the general structural formula of the compound is as shown in Formula I. Experiment demonstrates that the mercaptonicotinic acid compound could inhibit activity of botulinum toxin endopeptidase and tetanus toxin endopeptidase in vitro, which has a significant protective effect on botulinum toxin poisoning in mice, and can be used for preparing medicine intended to prevent and/or treat botulism, as well as to prevent botulinum toxin exposure and tetanus.


Patent
The Second Military Medical University | Date: 2011-12-09

The invention provides the sequences of two polypeptides comprising the amino acid sequences as shown in SEQ ID NO:1 and SEQ ID NO:2, which can be used for the preparation of monoclonal antibodies against human p28


Use of polypeptide micromolecule MLIF in preparing medicine for preventing and treating myocardial ischmia, where amino acid sequence of the polypeptide micromolecule MLIF is Met-Gln-Cys-Asn-Ser (SEQ ID NO:1).

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