the Second Hospital of Baoding

Baoding, China

the Second Hospital of Baoding

Baoding, China
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Li Y.-W.,The First Center Hospital of Baoding | He R.-L.,The Second Hospital of Baoding | Qi H.,The First Center Hospital of Baoding | Zhang Q.,The First Center Hospital of Baoding | And 7 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2014

BACKGROUND: Anatomic medullary locking (AML) femoral prosthesis is circular cylinder and has satisfactory efficacy. However, some scholars found the complications such as thigh pain, loss of bone at the proximal end of the femur, and wearing-related osteolysis. F2L femoral prosthesis is cone-shaped and also has satisfactory efficacy, but the thigh pain incidence is relatively low. OBJECTIVE: To compare the intermediate-long term results of AML versus F2L in total hip arthroplasty. METHODS: Between November 1997 and January 2005, we retrospectively reviewed 60 patients (66 hips) undergoing total hip arthroplasty using biological femoral prosthesis. At follow-up examination, 58 hips in 52 patients were available for clinical and roentgenographic review. 26 AML devices were placed in 24 patients, and 32 F2L devices were placed in 28 patients. The AML group were reviewed with an average of 12.7 years follow-up (range 10 years and 3 months to 15 years and 5 months), while the F2L group were reviewed with an average of 9.5 years follow-up (range 8 years and 3 months to 11 years and 1 month). The clinical results were evaluated with Harris methods and X-ray examination. Kaplan-Meier analysis was performed to evaluate the survival of femoral component. End point was radiographical loosening or revision of the femoral component for any reason. RESULTS AND CONCLUSION: There were no significant difference between AML and F2L about Harris score in the latest follow-up (P > 0.05). After surgery, the incidence of thigh pain was significantly lower in F2L group than that in AML group (P < 0.05). In AMKL group, the stress-shielding 1 level was observed in 21 hips (81%), and 2 level in five hips (19%); in F2L group, the stress shielding 0 level was observed in 20 hips (62%) and 1 level in 12 hips (38%). There were significant differences between the two groups (P < 0.05). The stress shielding showed significant differences between the two groups (P < 0.05). The incidence of osteolysis in F2L group was significantly lower than that in AML group (P < 0.05). Kaplan-Meier analysis showed that, the survival rate of both AML and F2L components were 1.0 (95% confidence interval: 0.98-1.00). Experimental findings indicate that, both AML and F2L femoral prosthesis have a satisfactory long-term efficacy after total hip arthroplasty, and the incidence of thigh pain and osteolysis is significantly lower in F2L group. © 2014, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.


Shi X.-L.,The Second Hospital of Baoding | Liu Q.-G.,The Second Hospital of Baoding | Zhang H.,The Second Hospital of Baoding | Tian Y.,The Second Hospital of Baoding | And 2 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2014

Background: Intravertebral bone graft to rebuild anterior and middle column structure and to recover vertebral morphology has been re-understood, and a suitable bone graft material can promote bone healing and be conducive to rebuild the long-term stability of the spine. Objective: To discuss the differences in clinical efficacy of three kinds of bone graft materials through unilateral pedicle to treat thoracolumbar burst fractures. Methods: Totally 102 thoracolumbar burst fracture patients were randomized into three groups: Autologous bone, autologous bone combined with allogeneic bone and allogeneic bone were implanted via the unilateral pedicle, respectively, in the three groups. We measured the percentage of height of the anterior edge of vertebral body and Cobb angle by X-Ray before and after bone grafting, and used CT to observe bone graft healing, and used Mimics to measure the defect area of vertebral body at the last follow-up. Results And Conclusion: All the 102 patients were followed-up for 24-36 months. The percentage of height of the anterior edge of vertebral body and Cobb angle of three groups were restored after bone grafting (p < 0.05), but there was no difference in the percentage of height of the anterior edge of vertebral body of three groups at different time point after bone grafting. The Cobb angle in the allogeneic bone group was bigger than that in the autologous bone group and autologous bone combined with allogeneic bone group at 9, 12 and 24 months after bone grafting (p < 0.05). The fracture healing rate of the allogeneic bone group at different time points was lower than that of the autologous bone group and autologous bone combined with allogeneic bone group (p < 0.05), and the area of bone defect was bigger than that in the autologous bone group and autologous bone combined with allogeneic bone group (p < 0.05). These findings indicate that these three bone graft materials can rebuild the vertebral body via the unilateral pedicle to treat thoracolumbar burst fracture, reduce the loss of vertebral height and Cobb angle, and decrease defect area of the vertebral body. The clinical efficacy of autologous bone combined with allogeneic bone to heal bone graft and reduce bone defect is similar to autologous bone, both of which are better than allogeneic bone alone. © 2014, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.


Li Q.-F.,the Second Hospital of Baoding | Zhan Y.-M.,the Second Hospital of Baoding | Zhong Y.-G.,the Second Hospital of Baoding | Zhang B.,the Second Hospital of Baoding | Ge C.-Q.,the Second Hospital of Baoding
Biomedical Chromatography | Year: 2016

Glycocholic acid (GCA) is a newly identified biomarker for hepatocellular carcinoma (HCC) patients. In this study, a method based on macromolecular crowding strategy has been applied for preparation of a molecularly imprinted polymer (MIP), which possesses high adsorption capacity for GCA. Polymethyl methacrylate was used as a macromolecular crowding agent, N-(3-aminopropyl)-methacrylamide hydrochloride as a functional monomer and ethylene dimethacrylate as a cross-linker. The morphology and binding characteristics of MIP were assessed by scanning electron microscopy and absorption experiments. The MIP was used as an adsorbent material to separate GCA, and the molecularly imprinted solid-phase extraction (MISPE) was carefully optimized. The MISPE combined with high-performance liquid chromatographic analysis was successfully used to determine the GCA in plasma and urine samples. When spiked levels ranged from 0.2 to 20 μmol L−1, the recoveries were between 94.3 and 100.5%. As a proof of principle, this proposed method has been validated on a small subset of HCC patients (n = 10) and healthy volunteers (n = 10). The average GCA concentrations of HCC patients in plasma and urine were about 25 and 2.8 times than that of healthy volunteers. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.


PubMed | the Second Hospital of Baoding
Type: Journal Article | Journal: Biomedical chromatography : BMC | Year: 2016

Glycocholic acid (GCA) is a newly identified biomarker for hepatocellular carcinoma (HCC) patients. In this study, a method based on macromolecular crowding strategy has been applied for preparation of a molecularly imprinted polymer (MIP), which possesses high adsorption capacity for GCA. Polymethyl methacrylate was used as a macromolecular crowding agent, N-(3-aminopropyl)-methacrylamide hydrochloride as a functional monomer and ethylene dimethacrylate as a cross-linker. The morphology and binding characteristics of MIP were assessed by scanning electron microscopy and absorption experiments. The MIP was used as an adsorbent material to separate GCA, and the molecularly imprinted solid-phase extraction (MISPE) was carefully optimized. The MISPE combined with high-performance liquid chromatographic analysis was successfully used to determine the GCA in plasma and urine samples. When spiked levels ranged from 0.2 to 20 mol L


PubMed | The Second Hospital of Baoding
Type: Journal Article | Journal: Molecular medicine reports | Year: 2016

The mechanism and associated factors of restenosis following intravascular stent implantation remain to be elucidated. The present twopart experimental and clinical study aimed to investigate the effects of tripterygium glycosides on instent restenosis subsequent to intraarterial therapy. Following endovascular stent implantation in rabbit iliac arteries, poststent outcomes were evaluated in cyclosporine groups, lowdose and highdose tripterygium glycosides groups and controls. Postoperative angiography indicated that vessel diameters were similar between groups; however, at 28days after receiving the therapeutic agents, vessels of the cyclosporine and tripterygium glycosides groups were significantly larger than those of the controls. Furthermore, three groups of patients had comparable baseline levels of interleukin (IL)10, IL18 and Creactive protein, and intimamedia thickness. However, 1month after stent implantation, levels of IL10 and IL18 were markedly reduced in the high and lowdose tripterygium glycosides groups compared with controls. At 6months after surgery, the stent patency rate in patients with bare stents was significantly lower than in patients receiving tripterygium glycosides (P0.009). In addition, the anklebrachial index was also higher than in those without tripterygium glycosides (P<0.001). Results of the experimental and clinical studies suggest that tripterygium glycosides may inhibit and possibly aid in the prevention of instent restenosis formation following endovascular treatment of lowerextremity artery disease.


Li Q.,The Second Hospital of Baoding | Ge X.,Central South University | Xu X.,The Second Hospital of Baoding | Zhong Y.,The Second Hospital of Baoding | Qie Z.,The Second Hospital of Baoding
International Journal of Clinical and Experimental Pathology | Year: 2014

Background: Gallstones and gallbladder polyps (GPs) are two major types of gallbladder diseases that share multiple common symptoms. However, their pathological mechanism remains largely unknown. The aim of our study is to identify gallstones and GPs related-genes and gain an insight into the underlying genetic basis of these diseases. Methods: We enrolled 7 patients with gallstones and 2 patients with GP for RNA-Seq and we conducted functional enrichment analysis and protein-protein interaction (PPI) networks analysis for identified differentially expressed genes (DEGs). Results: RNA-Seq produced 41.7 million in gallstones and 32.1 million pairs in GPs. A total of 147 DEGs was identified between gallstones and GPs. We found GO terms for molecular functions significantly enriched in antigen binding (GO:0003823, P=5.9E-11), while for biological processes, the enriched GO terms were immune response (GO:0006955, P=2.6E-15), and for cellular component, the enriched GO terms were extracellular region (GO:0005576, P=2.7E-15). To further evaluate the biological significance for the DEGs, we also performed the KEGG pathway enrichment analysis. The most signifi cant pathway in our KEGG analysis was Cytokine-cytokine receptor interaction (P=7.5E-06). PPI network analysis indicated that the significant hub proteins containing S100A9 (S100 calcium binding protein A9, Degree=94) and CR2 (complement component receptor 2, Degree=8). Conclusion: This present study suggests some promising genes and may provide a clue to the role of these genes playing in the development of gallstones and GPs.

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