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Yang B.,Chinese PLA General Hospital | Wang J.,Chinese PLA General Hospital | Cai L.-L.,Chinese PLA General Hospital | Zhu H.-L.,Chinese PLA General Hospital | And 3 more authors.

Background aims: Currently available treatment methods for advanced plasmacytoma include surgery, chemotherapy, radiotherapy, immunomodulatory agents, hematopoietic stem cell transplantation and donor lymphocyte infusion. We report a case of advanced refractory multiple solitary plasmacytomas in a 68-year-old Asian man with multiple bone lesions, in whom autologous cytokine-induced killer (CIK) cells were administered in an effort to eliminate residual tumor lesions. Methods: CIK cells were infused monthly for 21 courses. Results: The patient has survived 63 months since the first hospital visit without disease progression for 40 months. Conclusions: This case represents the first report of autologous CIK cell immunotherapy used successfully to suppress multiple solitary plasmacytomas and resolve bone lesions. © 2014 International Society for Cellular Therapy. Source

Yang B.,Chinese PLA General Hospital | Yu R.-L.,Chinese PLA General Hospital | Chi X.-H.,The Second Artillery General Hospital | Lu X.-C.,Chinese PLA General Hospital

Background:In recent years, a number of randomized controlled trials (RCTs) have reported on lenalidomide as a treatment for multiple myeloma (MM). Herein, we report results of a meta-analysis of RCTs examining the efficacy and safety of lenalidomide for MM.Patients and Methods:Databases were searched using the terms "lenalidomide or revlimid AND multiple myeloma."RCTs evaluating initial or maintenance therapeutic outcomes were included. Main outcome measures were response rates, progression-free survival (PFS), overall survival, and adverse events.Results:Seven trials were included (N = 192-614 participants). Lenalidomide doses and treatment regimens differed between trials. Complete response (CR) and very good partial response (VGPR) risk ratios (RR) favored lenalidomide over placebo (CR = 2.54, 95% confidence interval [CI] = 1.29-5.02; VGPR = 2.82, 95% CI = 1.30-6.09). The PFS hazard ratio favored lenalidomide over placebo (0.37, 95% CI = 0.33-0.41). For adverse events, neutropenia, deep vein thrombosis (DVT), infection, and hematologic cancer RR favored placebo over lenalidomide (neutropenia: 4.74, 95% CI = 2.96-7.57; DVT: 2.52; 95% CI: 1.60-3.98; infection: 1.98; 95% CI: 1.50-2.62; hematologic cancer: 3.20; 95% CI: 1.28-7.98).Conclusions:Lenalidomide is an effective treatment for MM; however, treatment-related adverse events must be considered and appropriate adjustments and/or prophylactic treatment should be initiated where possible. © 2013 Yang et al. Source

Yin S.,The Second Artillery General Hospital | Zhao K.,The Second Artillery General Hospital
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

The understanding of rectoanal inhibitory reflex (RAIR) is progressing for the latest 100 years. From the discovery of its important role in diagnosis of Hirschsprung's disease to all aspects of its development, reflex pathways, neural regulation and physiological functions, there have been more in-depth explorations. It is now recognized that a number of other diseases also have a more specific performance of RAIR. It has become an important and indispensable part to anorectal manometry. Research progress of rectoanal inhibitory reflex is reviewed in this article. Source

Sun W.J.,The Second Artillery General Hospital
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology

This study was aimed to detect the expression of B7-H1 gene in the acute myeloid leukemia (AML) cells and to explore its clinical significance. The B7-H1 gene expression was detected by real-time quantitative PCR in bone marrow mononuclear cells (BMMNC) from 40 newly diagnosed AML patients, 10 normal volunteers and 10 relapsed patients. The results showed that the expression of B7-H1 from de novo AML patients was lower than that from the normal volunteers, but it was higher in the relapsed patients. The expression level of B7-H1 gene before therapy was significantly higher in non CR patients than that in CR patients after therapy. It is concluded that there is a correlation between the expression level of B7-H1 gene and response to therapy. Source

Chen D.,National Center for Food Safety Risk Assessment | Miao H.,National Center for Food Safety Risk Assessment | Zou J.,The Second Artillery General Hospital | Lu L.,Thermo Fisher Scientific | And 2 more authors.
Analytical Letters

Phthalate esters are environmental hormones present in food due to their migration from packaging materials and other polymers. Gas chromatography and liquid chromatography coupled with mass spectrometry are the most widely used techniques for trace phthalate ester determination. However, a major problem in the analysis is contamination during the sample pretreatment, resulting in false-positive results or over-estimated concentrations. In this study, a simple, rapid, and sensitive method for the determination of seventeen phthalate esters in liquor using high resolution mass spectrometry was developed. Samples were directly analyzed without pretreatment, which reduced contamination and improved the accuracy of the results. In addition, the total time required for the analysis of one sample was only 15 minutes. The method showed good linearity (R2 > 0.995) in the ranges of 1 to 100 µg/L and 100 to 500 µg/L. The limits of detection and quantification were between 0.1 and 1.0 µg/L and 0.4 and 2.0 µg/L, respectively. The precision was evaluated by intra-day and inter-day measurements and expressed as the relative standard deviation (RSD). The values were less than 4.32% and 7.43%, respectively. The recovery values of phthalate esters from liquor fortified at 10, 50, 100, and 200 µg/L were determined to be 88.7% to 119.2%, with relative standard deviations of 0.3% to 9.6% (n = 6). The method was suitable for the rapid screening and confirmation of phthalate esters in liquor. © 2015, Copyright © Taylor & Francis Group, LLC. Source

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