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Yan Y.,The Second Artillary General Hospital Of Chinese Peoples Liberation Army | Chang Q.,The Second Artillary General Hospital Of Chinese Peoples Liberation Army | Li Q.,The Second Artillary General Hospital Of Chinese Peoples Liberation Army | Li L.,The Second Artillary General Hospital Of Chinese Peoples Liberation Army | And 3 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

Objects: To examine how vascular endothelia (VE)-cadherin plasma levels are correlated with parameters associated with endothelial function such as endothelin-1, nitric oxide, nitric oxide synthase and HbA1c in type 2 diabetic patients with coronary artery disease. Methods: VE-cadherin levels were analyzed by enzyme-linked im­munosorbent assays. Spearman’s correlation and multiple stepwise regression analyses were used to examine the relationship between plasma VE-cadherin and other factors. Results: By univariate correlation analysis, plasma VE-cadherin levels were significantly associated with age, total cholesterol, triglyceride, hemoglobin A1c, and en­dothelin-1. Multiple regression analysis (adjusted for age, total cholesterol, and triglyceride) showed that plasma VE-cadherin levels were independently and significantly associated with HbA1c and ET-1. Plasma VE-cadherin levels were significantly highest in patients with diabetes mellitus and coronary artery disease. While patients with diabe­tes mellitus had higher levels of VE-cadherin compared with healthy subjects. Conclusions: This study found that VE-cadherin levels might be a biomarker for some endothelial dysfunction associated with coronary artery disease in type 2 diabetes mellitus. © 2015, E-Century Publishing Corporation. All Rights Reserved.

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