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Cambridge, MA, United States

Spicer R.,The Rowland Institute at Harvard | Groover A.,U.S. Department of Agriculture
New Phytologist | Year: 2010

Secondary growth from vascular cambia results in radial, woody growth of stems. The innovation of secondary vascular development during plant evolution allowed the production of novel plant forms ranging from massive forest trees to flexible, woody lianas. We present examples of the extensive phylogenetic variation in secondary vascular growth and discuss current knowledge of genes that regulate the development of vascular cambia and woody tissues. From these foundations, we propose strategies for genomics-based research in the evolution of development, which is a next logical step in the study of secondary growth. No claim to original US government works. Journal compilation © New Phytologist Trust (2010). Source


Orth A.,The Rowland Institute at Harvard | Orth A.,RMIT University | Tomaszewski M.J.,Thermo Fisher Scientific | Ghosh R.N.,Thermo Fisher Scientific | Schonbrun E.,The Rowland Institute at Harvard
Optica | Year: 2015

Understanding the complexity of cellular biology often requires capturing and processing an enormous amount of data. In high-content drug screens, each cell is labeled with several different fluorescent markers and frequently thousands to millions of cells need to be analyzed in order to characterize biology’s intrinsic variability. In this work, we demonstrate a new microlens-based multispectral microscope designed to meet this throughput-intensive demand. We report multispectral image cubes of up to 1.30 gigapixels in the spatial domain, with up to 13 spectral samples per pixel, for a total image size of 16.8 billion spatial–spectral samples. To our knowledge, this is the largest multispectral microscopy dataset reported in the literature. Our system has highly reconfigurable spectral sampling and bandwidth settings, and we have demonstrated spectral unmixing of up to six fluorescent channels. This technology has the potential to speed up drug discovery by alleviating the imaging bottleneck in image-based assays. © 2015 Optical Society of America. Source

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