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Patuelli R.,University of Lugano | Patuelli R.,The Rimini Center for Economic Analysis | Reggiani A.,University of Bologna | Nijkamp P.,VU University Amsterdam | Schanne N.,Institute for Employment Research IAB
Journal of Geographical Systems | Year: 2011

In this paper, we present a review of various computational experiments concerning neural network (NN) models developed for regional employment forecasting. NNs are nowadays widely used in several fields because of their flexible specification structure. A series of NN experiments is presented in the paper, using two data sets on German NUTS-3 districts. Individual forecasts are computed by our models for each district in order to answer the following question: How relevant are NN parameters in comparison to NN structure? Comprehensive testing of these parameters is limited in the literature. Building on different specifications of NN models-in terms of explanatory variables and NN structures-we propose a systematic choice of NN learning parameters and internal functions by means of a sensitivity analysis. Our results show that different combinations of NN parameters provide significantly varying statistical performance and forecasting power. Finally, we note that the sets of parameters chosen for a given model specification cannot be light-heartedly applied to different or more complex models. © 2010 Springer-Verlag.


Patuelli R.,University of Bologna | Patuelli R.,The Rimini Center for Economic Analysis | Schanne N.,Institute for Employment Research IAB | Griffith D.A.,University of Texas at Dallas | And 2 more authors.
Journal of Regional Science | Year: 2012

The geographical distribution and persistence of regional/local unemployment rates in heterogeneous economies (such as Germany) have been, in recent years, the subject of various theoretical and empirical studies. Several researchers have shown an interest in analyzing the dynamic adjustment processes of unemployment and the average degree of dependence of the current unemployment rates or gross domestic product from the ones observed in the past. In this paper, we present a new econometric approach to the study of regional unemployment persistence, in order to account for spatial heterogeneity and/or spatial autocorrelation in both the levels and the dynamics of unemployment. First, we propose an econometric procedure suggesting the use of spatial filtering techniques as a substitute for fixed effects in a panel estimation framework. The spatial filter computed here is a proxy for spatially distributed region-specific information (e.g., the endowment of natural resources, or the size of the "home market") that is usually incorporated in the fixed effects coefficients. The advantages of our proposed procedure are that the spatial filter, by incorporating region-specific information that generates spatial autocorrelation, frees up degrees of freedom, simultaneously corrects for time-stable spatial autocorrelation in the residuals, and provides insights about the spatial patterns in regional adjustment processes. We present several experiments in order to investigate the spatial pattern of the heterogeneous autoregressive coefficients estimated for unemployment data for German NUTS-3 regions. We find widely heterogeneous but generally high persistence in regional unemployment rates. © 2012, Wiley Periodicals, Inc.


Patuelli R.,University of Bologna | Patuelli R.,The Rimini Center for Economic Analysis | Mussoni M.,University of Bologna | Mussoni M.,The Rimini Center for Economic Analysis | Candela G.,University of Bologna
Journal of Geographical Systems | Year: 2013

Culture is gaining increasing importance in the modern tourism industry and represents a significant force of attraction for tourists (both domestic and international). Cultural tourism allows destinations and regions to expand their customer base, diversify their offer, extend the stay of the tourist, and reduce seasonality. Great efforts are made, by national governments and regions, in order to obtain official designation regarding the relevance of their historical/cultural attractions, for example through UNESCO's World Heritage Sites (WHS) list. Such an aspect seems particularly relevant for a country like Italy, which has a high number of entries in the WHS list and where regions take an active role in promoting tourism. Using an 12-year panel of domestic tourism flows, we investigate the importance of the regional endowment in terms of WHS from two perspectives: (a) by separately estimating the effects, on tourism flows, of WHS located in the residence region of tourists and in the destination region; and (b) by taking into account potential spatial substitution/complementarity effects between regions due to their WHS endowment. Finally, a sensitivity analysis is offered to evaluate the spatial extent of the latter. © 2013 Springer-Verlag Berlin Heidelberg.


Schaap M.,Leiden University | Lemmers R.J.L.F.,Leiden University | Maassen R.,Leiden University | van der Vliet P.J.,Leiden University | And 6 more authors.
BMC Genomics | Year: 2013

Background: Macrosatellite repeats (MSRs), usually spanning hundreds of kilobases of genomic DNA, comprise a significant proportion of the human genome. Because of their highly polymorphic nature, MSRs represent an extreme example of copy number variation, but their structure and function is largely understudied. Here, we describe a detailed study of six autosomal and two X chromosomal MSRs among 270 HapMap individuals from Central Europe, Asia and Africa. Copy number variation, stability and genetic heterogeneity of the autosomal macrosatellite repeats RS447 (chromosome 4p), MSR5p (5p), FLJ40296 (13q), RNU2 (17q) and D4Z4 (4q and 10q) and X chromosomal DXZ4 and CT47 were investigated. Results: Repeat array size distribution analysis shows that all of these MSRs are highly polymorphic with the most genetic variation among Africans and the least among Asians. A mitotic mutation rate of 0.4-2.2% was observed, exceeding meiotic mutation rates and possibly explaining the large size variability found for these MSRs. By means of a novel Bayesian approach, statistical support for a distinct multimodal rather than a uniform allele size distribution was detected in seven out of eight MSRs, with evidence for equidistant intervals between the modes. Conclusions: The multimodal distributions with evidence for equidistant intervals, in combination with the observation of MSR-specific constraints on minimum array size, suggest that MSRs are limited in their configurations and that deviations thereof may cause disease, as is the case for facioscapulohumeral muscular dystrophy. However, at present we cannot exclude that there are mechanistic constraints for MSRs that are not directly disease-related. This study represents the first comprehensive study of MSRs in different human populations by applying novel statistical methods and identifies commonalities and differences in their organization and function in the human genome. © 2013 Schaap et al; licensee BioMed Central Ltd.


Grimpe C.,Center for European Economic Research | Grimpe C.,University of Zürich | Patuelli R.,University of Lugano | Patuelli R.,The Rimini Center for Economic Analysis
Annals of Regional Science | Year: 2011

Nanomaterials are seen as a key technology for the twenty-first century, and much is expected of them in terms of innovation and economic growth. They could open the way to many radically new applications, which would form the basis of innovative products. As nanomaterials are still in their infancy, universities, public research institutes and private businesses seem to play a vital role in the innovation process. Existing literature points to the importance of knowledge spillovers between these actors and suggests that the opportunities for these depend on proximity, with increasing distance being detrimental to the extent that spillovers can be realised. Due to the technological complexity, however, proximity could also be less important as relevant nanomaterials research is globally dispersed. Hence in this paper, we analyse the effects of co-location of R&D activities on nanomaterial patenting. Based on European Patent Office data at the German district level (NUTS-3), we estimate two negative binomial models in a knowledge production function framework and include a spatial filtering approach to adjust for spatial autocorrelation. Our results indicate that there is a significant positive effect of both public and private R&D on the production of nanomaterial patents. Moreover, we find a positive interaction between them which hints at the importance of their co-location for realising the full potential of an emerging technology like nanomaterials. © Springer-Verlag 2009.


Patuelli R.,University of Lugano | Patuelli R.,The Rimini Center for Economic Analysis | Griffith D.A.,University of Texas at Dallas | Tiefelsdorf M.,University of Texas at Dallas | Nijkamp P.,VU University Amsterdam
International Regional Science Review | Year: 2011

Regions, independent of their geographic level of aggregation, are known to be interrelated partly due to their relative locations. Similar economic performance among regions can be attributed to proximity. Consequently, a proper understanding, and accounting, of spatial liaisons is needed in order to effectively forecast regional economic variables. Several spatial econometric techniques are available in the literature, which deal with the spatial autocorrelation (SAC) in geographically referenced data. The experiments carried out in this article are concerned with the analysis of the SAC observed for unemployment rates in 439 NUTS-3 German districts. The authors employ a semiparametric approach-spatial filtering-in order to uncover spatial patterns that are consistently significant over time. The authors first provide a brief overview of the spatial filtering method and illustrate the data set. Subsequently, they describe the empirical application carried out: that is, the spatial filtering analysis of regional unemployment rates in Germany. Furthermore, the authors exploit the resulting spatial filter as an explanatory variable in a panel modeling framework. Additional explanatory variables, such as average daily wages, are used in concurrence with the spatial filter. Their experiments show that the computed spatial filters account for most of the residual SAC in the data. © 2011 SAGE Publications.


Oud J.H.L.,Radboud University Nijmegen | Folmer H.,University of Groningen | Folmer H.,Northwest University, China | Patuelli R.,University of Bologna | And 3 more authors.
Geographical Analysis | Year: 2012

(Spatial) panel data are routinely modeled in discrete time (DT). However, compelling arguments exist for continuous-time (CT) modeling of (spatial) panel data. Particularly, most social processes evolve in CT, so that statistical analysis in DT is an oversimplification, gives an incomplete representation of reality, and may lead to misinterpretation of estimation results. The most compelling reason for a CT approach is that, in contrast to DT modeling, it allows adequate modeling of dynamic adjustment processes. This article introduces spatial dependence in a CT modeling framework. We propose a nonlinear structural equation model (SEM) with latent variables for estimation of the exact discrete model (EDM), which links CT model parameters to DT observations. The use of a SEM with latent variables enables a specification that accounts for measurement errors in the variables, leading to a reduction of attenuation bias (i.e., disattenuation). The SEM-CT model with spatial dependence developed here is the first dynamic SEM with spatial dependence. A simple regional labor market model for Germany, comprising changes in unemployment and population as endogenous state variables, and changes in regional average wages and in the structure of the manufacturing sector as exogenous input variables, illustrates this spatial econometric SEM-CT framework. © 2012 The Ohio State University.

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