The Research Center for Quality Engineering Technology of Traditional Chinese Medicine in Guangdong Universities

Guangzhou, China

The Research Center for Quality Engineering Technology of Traditional Chinese Medicine in Guangdong Universities

Guangzhou, China
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Zhou W.,Guangdong Pharmaceutical University | Zhou W.,The Key Unit of Chinese Medicine Digitalization Quality Evaluation of SATCM | Zhou W.,The Research Center for Quality Engineering Technology of Traditional Chinese Medicine in Guangdong Universities | Yuan W.-F.,Guangdong Pharmaceutical University | And 11 more authors.
Journal of Ethnopharmacology | Year: 2016

Ethnopharmacological relevance Traditional Chinese medicine (TCM) has been widely used in China and its surrounding countries in clinical treatments for centuries-long time. However, due to the complexity of TCM constituents, both action mechanism and material base of TCM remain nearly unknown. Aim of the study The present study was designed to uncover the action mechanism and material base of TCM in a low-cost manner. Materials and methods Compound Danshen dripping pills (DSP) is a widely used TCM for treatment of atherosclerosis, and was researched here to demonstrate the effectiveness of our method. We constructed a heterogeneous network for DSP, identified the significant network module, and analyzed the primary pharmacological units by performing GO and pathways enrichment analysis. Results Two significant network modules were identified from the heterogeneous network of DSP, and three compounds out of four hub nodes in the network were found to intervene in the process of atherosclerosis. Moreover, 13 out of 20 enriched pathways that were ranked in top 10 corresponding to both the two pharmacological units were found to be involved in the process of atherosclerosis. Conclusions Quercetin, luteolin and apigenin may be the main active compounds which modulate the signaling pathways, such as metabolism of xenobiotics by cytochrome P450, retinol metabolism, etc. The present method helps reveal the action mechanism and material base of DSP for treatment of atherosclerosis. © 2016 Elsevier Ireland Ltd


Wang W.-W.,Guangdong Pharmaceutical University | Wang W.-W.,The Key Unit of Chinese Medicine Digitalization Quality Evaluation of State Administration of Tranditional Chinese Medicine | Wang W.-W.,The Research Center for Quality Engineering Technology of Traditional Chinese Medicine in Guangdong Universities | Wei W.-W.,Guangdong Pharmaceutical University | And 15 more authors.
Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis | Year: 2015

To establish a phenylketonuria screening model by FTIR/ATR spectroscopy, and to compare the effects of different pretreatment methods, such as baseline correction, smoothing, derivation, Fourier deconvolution, on the model quality. A consensus partial least squares regression method (cPLS) was used to build the quantitative model of phenylalanine in dried blood spots. The effects of different pretreatment methods on the model performance were investigated, using the correlation coefficient (r), root mean square error of prediction (RMSEP), mean relative error (MRE) and predictive accuracy (Acc). The nine-point smoothing coupled with the first differential was found to perform the best. Compared with the model by the original spectra, its r, RMSEP, MRE and Acc were improved from 0.822 7, 115.8, 0.395 and 94.6 to 0.889 9, 102.2, 0.286 and 100, respectively. With the advantages of fast speed, easy process, no reagents consumption and environmental protection, the present method is expected to become a simple and green technology for rapidly screening the neonatal phenylketonuria in a large population. ©, 2015, Science Press. All right reserved.

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