Hu J.-B.,Zhejiang University |
Dong M.-J.,Ningbo No.2 Hospital |
Zhang J.,The PLA 117 Hospital
Tropical Journal of Pharmaceutical Research | Year: 2016
Purpose: To design a dual inhibitor of natural origin capable of targeting ErbB1 and ErbB2 kinases for the treatment of lung cancer. Method: Advanced In silico drug designing techniques were explored in this study. Sequence and structure analysis of ErbB1 and ErbB2 was followed by three dimensional (3D) pharmacophore. The generated model was used for molecular docking simulation studies for predicting the best natural dual inhibitors, the selected inhibitors were subjected to absorption, distribution, metabolism, excretion and toxicology (ADME/Tox) prediction. Results: The results confirmedfive phytochemicals, viz. hyoscyamide, cannabisin F, cochinchinenene D, cannabisin E, and heliotropamide and five FDA approved drugs namely fesoterodine, antrafenine, fluspirilene, posaconazole, and iloprost to be potential inhibitors of both ErbB1 and ErbB2. The shortlisted compounds from both the panels were showing better MolDock score than the two reference drugs (Lapatinib and Afatinib). Conclusion: The 3D pharmacophore modelling and molecular docking simulations gave us ten compounds that successfully exploited dual inhibition of ErbB1 and ErbB2. With 8 and 12 hydrogen bonds with ErbB1 and ErbB2 respectively cannabisin F showed best interaction of all. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.
Yang Y.-H.,The PLA 117 Hospital |
Zheng J.,The PLA 117 Hospital |
Lou S.-L.,The PLA 117 Hospital
International Journal of Clinical and Experimental Medicine | Year: 2014
Objective: To investigate the causes and managements of early postoperative complications of degenerative scoliosis (DS) treated with internal pedicle screw fixation. Methods: From Jan 2000 to Apr 2013, 325 DS patients treated with internal pedicle screw fixation in our hospital were retrospectively involved. The categories, causes, managements and outcomes of early postoperative complications were statistically analyzed. Results: Early postoperative complications occurred in 10.76% of the patients including 16 cases of lower limb numb or pain, 6 cases of decreased lower limb sensitivity and motor functions, which accounted for 62.86% of all complications, followed by incision infections (4/35, 11.43%) and rare cases of cerebrospinal fluid leakage, cardiac and renal inadequacy, urinary system and pulmonary infections. The incidence of overall complications (19.79%, p = 0.001) and nerve injuries (11.46%, p = 0.000) were significantly higher in long-segment than in short-segment fixations. Improper screw implanting, over correction of scoliosis and insufficient blood supply of the spinal cord during operation were risk factors for early postoperative complications and most of them were cured by anti-infection medication, incision dressing change, nerve nourishment, adjusting the screws and anti-osteoporosis treatments within 6 months after surgery. Only three cases with severe nerve injury did not improve until the 6 months postoperative follow-up. Conclusions: Most of the postoperative complications in our DS patients disappeared within 6 months after surgery and more than half of complications were nerve injuries. © 2014, E-Century Publishing Corporation. All Rights Reserved.
Liu M.,The PLA 117 Hospital |
Zhang W.-D.,The PLA 117 Hospital |
Zhang M.-O.,Hangzhou Traditional Chinese Medicine Hospital |
Chen X.-C.,The PLA 117 Hospital |
Zou Q.,The PLA 117 Hospital
Journal of Biomaterials and Tissue Engineering | Year: 2015
The aim of the present study was to develop sustained release (SR) matrix tablet of ketorolac tromethamine using natural polymer xanthan gum with cellulose derivative (sodiumcarboxy methyl cellulose) and Polyvinylpyrrolidone K30 for effective management of pain and inflammation in spinal injuries. The formulated tablets were evaluated for uniformity of weight, drug content, friability, hardness, thickness, swelling index, in vitro drug release and in vivo analgesic and antiinflammatory activity. The physicochemical properties of tablets were found within the limits. The SR matrix tablets of ketorolac showed good swelling (increased with xanthan gum’s concentration), drug content and the dissolution profile. The drug released increased with decrease in swelling properties. The formulation with 20% w/v of xanthan showed the lowest % drug release (49.6%) at the end of 8 hrs. It was concluded that increasing the concentration of gum from 5% w/v to 20% w/v in the formulation decreased the amount of drug release from the tablet. The formulation with 10% xanthan gum found to be the best in % pain reduction (54.6%) and % inhibition of paw edema (51.58%). The xanthan gum based SR matrix tablets of ketorolac tromethamine can be explored for potential therapeutic uses in spinal injuries. © 2015 American Scientific Publishers. All rights reserved.
Chen X.-C.,The PLA 117 Hospital |
Pan Y.-Q.,The PLA 117 Hospital |
Zhao K.-Y.,The PLA 117 Hospital |
Liu M.,The PLA 117 Hospital |
He D.,The PLA 117 Hospital
Chinese Journal of Interventional Imaging and Therapy | Year: 2013
Objective: To explore the diagnostic value of hiding degenerative changes of lumbar spine with with self-controlled axial loading device of the lumbar spine. Methods: Totally 120 patients were examined by paired posas relaxed position CT/MR (PRP CT/MR) and axial compression in extension CT/MR (ACE CT/MR) with self-controlled axial loading device of the lumbar spine controlled, with compression less than 50% of the patient's weight. The results were compared with conventional CR/MR. Decrease of dural sac cross sectional area 015 mm2) to values smaller than 75 mm2, narrow lateral recess, narrow intervertebral foramen lumbar disk heriation were considered as additional valuable information (AVI). Results: AVI was found in 43 of 120 patients, including decrease of dural sac cross sectional area in 33 patients, narrow lateral recess and (or) narrow intervertebral foramen in 12, lumbar disk heriation in 11 and to a greater extent in 15 patients. AVI was found in 40 of 98 (40/98, 40.82%) patients with sciatica and 3 of 22 (3/22, 13.64%) patients with low back pain (P<0.05). Conclusion: ACE CT/MRI with self-controlled axial loading device has important value of clinical evaluation on hiding degenerative changes of lumbar spine.