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Zheng X.,Fujian Medical University | Tang W.,Jiangsu University | Wang Y.,The Peoples Hospital Of Xishuangbanna Dai Autonomous Prefecture | Gu H.,Shanghai JiaoTong University | And 2 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2016

Objectives: The association of intercellular adhesion molecule 1 (ICAM-1) rs5498 A>G (K469E) polymorphism with coronary artery disease (CAD) susceptibility has been widely explored; however, these studies have yielded conflicting results. To address the correlation more precisely, we performed this pooled analysis. Design and Methods: EmBase, PubMed and China Biology Medicine (CBM) databases were independently searched by two authors for eligible studies before January 15, 2016. Fixed-effects or random-effects model was used to calculate the odds ratios (ORs) and their 95% confidence intervals (CIs) when appropriate. Results: Meta-analysis of total studies demonstrated that variants of ICAM-1 rs5498 A>G were significantly correlated with the decreased susceptibility of CAD. Subgroup analyses by different types of CAD and different populations also identified a significant correlation. In addition, sensitivity analysis further suggested a relationship of ICAM-1 rs5498 A>G polymorphism with CAD risk. Conclusions: In summary, the present meta-analysis of available data indicates that the ICAM-1 rs5498 A>G polymorphism probably decreases the susceptibility of CAD, especially in Caucasians and myocardial infarction subgroups. © 2016, E-Century Publishing Corporation. All rights reserved.


Liu C.,Jiangsu University | Tang W.,Jiangsu University | Chen S.,Fujian Medical University | Wang Y.,The Peoples Hospital Of Xishuangbanna Dai Autonomous Prefecture | And 3 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

Esophageal cancer is the sixth leading cause of cancer-related deaths worldwide. It is very aggressive with a poor prognosis. Besides environmental risk factors, genetic factors might contribute to the esophageal cancer carcinogenesis. To evaluate the association between the risk of esophageal squamous cell carcinoma (ESCC) and genetic variants in IGFBP3, we conducted a hospital-based case-control study to assess the genetic effects of these SNPs. A total of 380 esophageal squamous cell carcinoma (ESCC) cases and 380 controls were recruited for this study. The genotypes were determined using a matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The IGFBP3 single nucleotide polymorphisms (SNPs) rs2270628 C>T, rs10282088 C>A, and rs3110697 G>A were associated with a significantly decreased risk of ESCC. However, our results were obtained with a limited sample size. To confirm the current findings, larger studies with other ethnic populations are required. © 2015, E-Century Publishing Corporation. All rights reserved.


Ding H.,Jiangsu University | Wang Y.,The Peoples Hospital Of Xishuangbanna Dai Autonomous Prefecture | Jiang H.,Jiangsu University | Zhang S.,Changzhou No 3 Peoples Hospital | And 2 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2016

The possible correlation of cyclooxygenase-2 (COX-2) rs5275T>C polymorphism with lung cancer risk has been widely investigated. However, the results remain controversial. To identify the relationship more precisely, we carried out a pooled analysis of ten publications involving a total of 11,682 subjects. In this study, ten publications were recruited by extensive searching PubMed and EMBASE databases up to September 14, 2015. The lung cancer risk correlated with the COX-2 rs5275T>C variants was evaluated by odds ratios (ORs) with 95% confidence intervals (95% CIs). Publication bias, heterogeneity and sensitivity analysis were also assessed. The results showed that the COX-2 rs5275T>C variants were not associated with overall lung cancer susceptibility. In a stratified analysis by histology, the relationship between COX-2 rs5275T>C polymorphism and decreased lung cancer susceptibility was significant in mixed histology lung cancer. In summary, our study demonstrated that the COX-2 rs5275T>C polymorphism may be a lung cancer susceptibility factor. © 2016, E-Century Publishing Corporation. All rights reserved.


Zhang S.,Changzhou No 3 Peoples Hospital | Wang Y.,The Peoples Hospital Of Xishuangbanna Dai Autonomous Prefecture | Jiang H.,Jiangsu University | Liu C.,Jiangsu University | And 2 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2016

The association between Cyclin D1 (CCND1) rs9344 G>A (G870A) polymorphism and gastric cancer (GC) has been extensively investigated; however, the results remain conflicting. In the present study, we performed a meta-analysis to further address this issue. We carried out a meta-analysis, recruiting seven publications with 1,350 GC cases and 1,823 controls, to obtain a more comprehensive evaluation between the CCND1 rs9344 G>A polymorphism and the susceptibility of gastric cancer. After combining all eligible studies, we found null association between CCND1 rs9344 G>A polymorphism and GC in all genetic models. In a stratified analysis by ethnicity, sig­nificant decreases in GC risk were observed for Caucasians in one genetic model: AA vs. GA+GG (OR, 0.65; 95% CI, 0.44-0.96; P = 0.032). Begg’s Funnel plots and Egger’s tests were created to measure the publication bias, and the shape of funnel was symmetry in four genetic models, suggesting the stability of our findings. The results highlight that CCND1 rs9344 G>A variants may be associated with the risk of gastric cancer among Caucasians. © 2016, E-Century Publishing Corporation. All Rights Reserved.


Tang W.,Fujian Medical University | Wang Y.,The Peoples Hospital Of Xishuangbanna Dai Autonomous Prefecture | Chen Y.,Fujian Provincial Cancer Hospital | Gu H.,Jiangsu University | And 2 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

Objectives: The correlation between intercellular adhesion molecule 1 (ICAM-1) common polymorphisms (rs5498 A>G and rs3093030 C>T) and cancer susceptibility has been explored in various ethnic groups and different cancer types; however, these investigations have yielded contradictory results. To address the relationship more precisely, we performed this meta-analysis. Design and methods: EmBase, PubMed and China National Knowledge Infrastructure (CNKI) databases were searched by two authors independently for eligible publications before April 8, 2015. Random-effects or fixed-effects model was harnessed to calculate the pooled odds ratios (ORs) and 95% confidence intervals (CIs) when appropriate. Results: The result suggested that the ICAM-1 rs5498 A>G polymorphism is not associated with cancer susceptibility in overall cancer. In a stratified analysis by ethnicity, a significant increased cancer risk was identified among Asians, but the inverse association was found among Caucasians. In a stratified analysis by cancer type, ICAM-1 rs5498 A>G polymorphism was associated with a significantly increased risk of oral cancer, but with protection from colorectal cancer and melanoma. ICAM-1 rs3093030 C>T polymorphism is not correlated with cancer susceptibility. Conclusions: In summary, this meta-analysis highlights that the ICAM-1 rs5498 A>G polymorphism probably contributes to decreased susceptibility to cancer, especially in Caucasians, in melanoma and colorectal cancer subgroup, but it may be a risk factor for oral cancer and Asians. © 2015, E-Century Publishing Corporation. All rights reserved.


Wang Y.,The Peoples Hospital Of Xishuangbanna Dai Autonomous Prefecture | Jiang H.,Jiangsu University | Liu T.,Fujian Medical University | Tang W.,Jiangsu University | Ma Z.,The Peoples Hospital Of Xishuangbanna Dai Autonomous Prefecture
International Journal of Clinical and Experimental Medicine | Year: 2015

The association between cyclooxygenase-2 (COX-2) -1195G>A (rs689466) polymorphism and cancer risk has been extensively explored. However, the results of previous studies remain controversial. To address this gap, we performed an updated meta-analysis of fifty-eight studies involving a total of 50,672 subjects. Searching of PubMed and Embase databases was performed for publications on the association between COX-2 -1195G>A polymorphism and the risk of cancer. Statistical correlation was identified between COX-2 -1195G>A variants and overall cancer risk in five genetic models. In a sub-group analysis based on cancer type, significant association between COX-2 -1195G>A polymorphism and increased risk of gastric cancer, pancreatic cancer, hepatocellular carcinoma and other cancers was found. In a sub-group analysis by ethnicity, increased cancer risk was observed among Asians instead of Caucasians, Africans and mixed populations. Furthermore, in a sub-group analysis based on cancer system, increased cancer risk was found in digestive system cancer and other system cancer. Non-parametric “trim-and-fill” method was harnessed as a sensitivity analysis method and the results suggested our findings reliable. In summary, the results of our meta-analysis highlight that COX-2 -1195G>A polymorphism may be a risk factor for cancer. © 2015, E-Century Publishing Corporation. All rights reserved.


Wang Y.,The Peoples Hospital Of Xishuangbanna Dai Autonomous Prefecture | Shu Y.,The Peoples Hospital Of Xishuangbanna Dai Autonomous Prefecture | Jiang H.,Jiangsu University | Sun B.,Jiangsu University | And 2 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

Interleukin-2 (IL-2) is an important member of the cytokines that play critical roles in carcinogenesis. Many studies have investigated the association between IL-2 rs2069762 polymorphism and cancer risk; however, the results remain controversial. The aim of this study is to assess the correlation between IL-2 rs2069762 polymorphism and cancer risk. All eligible case-control studies accorded with criteria published up to March 30, 2015 were identified by searching Embase and PubMed databases. Association between IL-2 rs2069762 polymorphism and cancer risk was assessed by crude odds ratios (ORs) with 95% confidence intervals (CIs), respectively. Ten casecontrol studies from nine publications with 3095 cases and 4480 controls were included. Overall, IL-2 rs2069762 polymorphism was not associated with cancer risk in five genetic models (G vs. T: OR = 1.07, 95% CI = 0.95-1.21, P = 0.278; GG vs. TT: OR = 1.16, 95% CI = 0.86-1.57, P = 0.317; GG + TG vs. TT: OR = 1.09, 95% CI = 0.93-1.28, P = 0.273; GG vs. TT + TG: OR = 1.11, 95% CI = 0.85-1.44, P = 0.451; TG vs. TT: OR = 1.08, 95% CI = 0.92-1.28, P = 0.339, respectively). Similar results were also obtained after stratified by ethnicity and cancer type. This metaanalysis indicates that IL-2 rs2069762 T>G polymorphism is not associated with cancer risk. And the same conclusion is drawn after stratified by cancer type and ethnicity. © 2015, E-Century Publishing Corporation. All rights reserved.


Tang W.,Fujian Medical University | Wang Y.,The Peoples Hospital Of Xishuangbanna Dai Autonomous Prefecture | Chen B.,Fujian Medical University | Lin W.,Fujian Medical University | And 3 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2016

The association between cytotoxic T-lymphocyte antigen-4 (CTLA-4) rs5742909 C>T (-318C/T) polymorphism and cancer risk has been widely investigated, while many publications have reported controversial results. The aim of this study was to carry out a meta-analysis evaluating the association between CTLA-4 rs5742909 C>T polymorphism and cancer risk. The PubMed, EMBASE and CBM (China Biology Medicine), as well as CNKI (China National Knowledge Infrastructure) databases were extensively searched up to June 22, 2015 for relevant articles investigating the relationship between CTLA-4 rs5742909 C>T polymorphism and cancer risk. A meta-analysis was conducted using STATA software (version 12.0). Thirty case-control studies from twenty-nine publications were recruited for analysis. The results indicated a significant difference in genotype and allele distributions of CTLA-4 rs5742909 C>T polymorphism between cancer cases and controls. A slight publication bias was detected in this study; therefore, non-parametric “trim-and-fill” method was used to check the stability of our results. The adjusted ORs and CIs indicated that CTLA-4 rs5742909 C>T polymorphism might be a risk factor for cancer, suggesting the reliability of our results. This meta-analysis suggests that CTLA-4 rs5742909 C>T polymorphism may be associated with cancer susceptibility. © 2016, E-Century Publishing Corporation. All rights reserved.


Tang W.,Fujian Medical University | Chen Y.,Fujian Provincial Cancer Hospital | Wang Y.,The Peoples Hospital Of Xishuangbanna Dai Autonomous Prefecture | Gu H.,Jiangsu University | And 2 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

Background: Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling events. Several studies have been conducted to explore the associations of PPARG polymorphisms with breast cancer (BC), yet the findings are inconsistent. Methods: Databases of Pubmed and Embase were searched until October 5, 2014. The association between PPARG polymorphisms and BC risk was determined by crude odds ratios (ORs) with their 95% confidence intervals (CIs). Results: Finally, there are nine publications involving 3,931 BC cases and 5,382 controls included in this meta-analysis. No significant association was observed between PPARG rs1801282 C>G variants and overall BC risk in all genetic comparison models. However, in a subgroup analysis by ethnicity, significant association was observed between PPARG rs1801282 C>G variants and decreased BC risk in three genetic models: GG+CG vs. CC (OR, 0.83; 95% CI, 0.71-0.96; P = 0.011), CG vs. CC (OR, 0.82; 95% CI, 0.71-0.96; P = 0.011) and G vs. C (OR, 0.85; 95% CI, 0.75-0.97; P = 0.016) in Caucasians and in a subgroup analysis by menopausal status, significantly decreased BC risk was also found in two genetic models: GG+CG vs. CC (OR, 0.79; 95% CI, 0.67-0.95; P = 0.011) and CG vs. CC (OR, 0.77; 95% CI, 0.64-0.92; P = 0.005) in post-menopause subgroup. For PPARG rs3856806 C>T, we found no significant association between PPARG rs3856806 C>T polymorphism and breast cancer. Conclusions: In summary, despite some limitations, the results suggest that PPARG rs1801282 C>G polymorphism may be a protective factor for BC in Caucasians and in post-menopause women. © 2015, E-Century Publishing Corporation. All rights reserved.


Ding G.,Jiangsu University | Wang Y.,The Peoples Hospital Of Xishuangbanna Dai Autonomous Prefecture | Tang W.,Jiangsu University | Gu H.,Jiangsu University | And 4 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2016

Spatiotemporal expression pattern of vascular endothelial growth factor (VEGF) are required for proper heart morphogenesis. Genetic variants of VEGF contribute to the production and/or biological activity may determine the risk of congenital heart disease (CHD). To explore the impact of VEGF functional SNPs -2578 C>A, -1498 T>C, -634 G>C, +936 C>T on the susceptibility of CHD, we genotyped four functional polymorphisms of VEGF (-2578 C>A, -1498 T>C, -634 G>C, +936 C>T) in a hospital based case-control study of 476 CHD cases and 557 non-CHD controls in a Chinese population. We did not find any significant associations between the four VEGF polymorphisms and the risk of CHD or a certain kind of CHD such as ventricular septal defect (VSD) or tetralogy of Fallot (TOF). However, C-2578T-1498G-634C+936, C-2578T-1498C-634T+936 and G-2578G-1498G-634T+936 haplotypes were correlated with a significantly increased susceptibility of CHD. The C-2578T-1498G-634T+936 haplotypes were correlated with a significantly decreased risk of CHD. © 2016, E-Century Publishing Corporation. All rights reserved.

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