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Tang W.,Fujian Medical University | Chen Y.,Fujian Provincial Cancer Hospital | Wang Y.,The Peoples Hospital of Xishuangbanna Dai Autonomous Prefecture | Gu H.,Jiangsu University | And 2 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

Background: Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling events. Several studies have been conducted to explore the associations of PPARG polymorphisms with breast cancer (BC), yet the findings are inconsistent. Methods: Databases of Pubmed and Embase were searched until October 5, 2014. The association between PPARG polymorphisms and BC risk was determined by crude odds ratios (ORs) with their 95% confidence intervals (CIs). Results: Finally, there are nine publications involving 3,931 BC cases and 5,382 controls included in this meta-analysis. No significant association was observed between PPARG rs1801282 C>G variants and overall BC risk in all genetic comparison models. However, in a subgroup analysis by ethnicity, significant association was observed between PPARG rs1801282 C>G variants and decreased BC risk in three genetic models: GG+CG vs. CC (OR, 0.83; 95% CI, 0.71-0.96; P = 0.011), CG vs. CC (OR, 0.82; 95% CI, 0.71-0.96; P = 0.011) and G vs. C (OR, 0.85; 95% CI, 0.75-0.97; P = 0.016) in Caucasians and in a subgroup analysis by menopausal status, significantly decreased BC risk was also found in two genetic models: GG+CG vs. CC (OR, 0.79; 95% CI, 0.67-0.95; P = 0.011) and CG vs. CC (OR, 0.77; 95% CI, 0.64-0.92; P = 0.005) in post-menopause subgroup. For PPARG rs3856806 C>T, we found no significant association between PPARG rs3856806 C>T polymorphism and breast cancer. Conclusions: In summary, despite some limitations, the results suggest that PPARG rs1801282 C>G polymorphism may be a protective factor for BC in Caucasians and in post-menopause women. © 2015, E-Century Publishing Corporation. All rights reserved.


Tang W.,Fujian Medical University | Wang Y.,The Peoples Hospital of Xishuangbanna Dai Autonomous Prefecture | Chen Y.,Fujian Provincial Cancer Hospital | Gu H.,Jiangsu University | And 2 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

Objectives: The correlation between intercellular adhesion molecule 1 (ICAM-1) common polymorphisms (rs5498 A>G and rs3093030 C>T) and cancer susceptibility has been explored in various ethnic groups and different cancer types; however, these investigations have yielded contradictory results. To address the relationship more precisely, we performed this meta-analysis. Design and methods: EmBase, PubMed and China National Knowledge Infrastructure (CNKI) databases were searched by two authors independently for eligible publications before April 8, 2015. Random-effects or fixed-effects model was harnessed to calculate the pooled odds ratios (ORs) and 95% confidence intervals (CIs) when appropriate. Results: The result suggested that the ICAM-1 rs5498 A>G polymorphism is not associated with cancer susceptibility in overall cancer. In a stratified analysis by ethnicity, a significant increased cancer risk was identified among Asians, but the inverse association was found among Caucasians. In a stratified analysis by cancer type, ICAM-1 rs5498 A>G polymorphism was associated with a significantly increased risk of oral cancer, but with protection from colorectal cancer and melanoma. ICAM-1 rs3093030 C>T polymorphism is not correlated with cancer susceptibility. Conclusions: In summary, this meta-analysis highlights that the ICAM-1 rs5498 A>G polymorphism probably contributes to decreased susceptibility to cancer, especially in Caucasians, in melanoma and colorectal cancer subgroup, but it may be a risk factor for oral cancer and Asians. © 2015, E-Century Publishing Corporation. All rights reserved.


Tang W.,Jiangsu University | Wang Y.,The Peoples Hospital of Xishuangbanna Dai Autonomous Prefecture | Jiang H.,Jiangsu University | Liu C.,Jiangsu University | And 4 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

The correlation between insulin receptor substrate-1 (IRS-1) rs1801278G>A polymorphism and polycystic ovary syndrome (PCOS) has been widely studied. However, the results of these studies are conflicting. The current study provides an assessment of the association between the genetic susceptibilities of IRS-1 rs1801278G>A polymorphism and PCOS. A comprehensive meta-analysis was carried out in over 4,555 subjects included in twenty publications which were published up to June 26, 2015. Our findings suggested that the IRS-1 rs1801278G>A genotype was correlated with the susceptibility of PCOS in the allele comparison, heterozygote comparison and the dominant genetic model. In the dominant genetic model, variant A allele carriers (AA+GA) of IRS-1 rs1801278G>A polymorphism increased the susceptibility of PCOS comparing to the homozygote GG [odds ratio (OR)=1.82, 95% confidence interval (CI) 1.30-2.53 for AA+GA vs. GG]. The analysis by different ethnicity groups highlighted that Caucasian population (OR=1.96, 95% CI 1.26-3.04 for AA+GA vs. GG) had significant increased PCOS susceptibility. Bias diagnosis indicated there are slight publication biases in some genetic models, suggesting that these findings should be interpreted with very caution. In summary, our findings suggested that IRS-1 rs1801278G>A polymorphism may be a risk factor for PCOS. © 2015, International Journal of Clinical and Experimental Medicine. All Rights reserved.


Liu C.,Jiangsu University | Tang W.,Jiangsu University | Chen S.,Fujian Medical University | Wang Y.,The Peoples Hospital of Xishuangbanna Dai Autonomous Prefecture | And 3 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

Esophageal cancer is the sixth leading cause of cancer-related deaths worldwide. It is very aggressive with a poor prognosis. Besides environmental risk factors, genetic factors might contribute to the esophageal cancer carcinogenesis. To evaluate the association between the risk of esophageal squamous cell carcinoma (ESCC) and genetic variants in IGFBP3, we conducted a hospital-based case-control study to assess the genetic effects of these SNPs. A total of 380 esophageal squamous cell carcinoma (ESCC) cases and 380 controls were recruited for this study. The genotypes were determined using a matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The IGFBP3 single nucleotide polymorphisms (SNPs) rs2270628 C>T, rs10282088 C>A, and rs3110697 G>A were associated with a significantly decreased risk of ESCC. However, our results were obtained with a limited sample size. To confirm the current findings, larger studies with other ethnic populations are required. © 2015, E-Century Publishing Corporation. All rights reserved.


Chen B.,Fujian Medical University | Wang Y.,The Peoples Hospital of Xishuangbanna Dai Autonomous Prefecture | Lin W.,Fujian Medical University | Jiang H.,Jiangsu University | And 5 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2016

Several investigations have focused on the relationship between paraoxonase-1 (PON-1) polymorphisms and the risk of polycystic ovary syndrome (PCOS); however, the result remains conflicting. To obtain a more precise estimation of the correlation between PON-1 polymorphisms [rs705379 C>T (-108C/T), rs854560 T>A (55Leu/Met) and rs662 A>G (192Gln/Arg)] and the risk of PCOS, we performed a meta-analysis of 940 PCOS cases and 881 controls concerning rs705379 C>T polymorphism, 1,436 PCOS cases and 1,053 controls concerning rs854560 T>A polymorphism and 1,306 PCOS cases and 983 controls concerning rs662 A>G polymorphism from eight publi­cations. The crude odds ratios (ORs) with 95% confidence intervals (CIs) were harnessed to measure the strength of the association. Our findings suggested that there was an evidence of a correlation between the PON-1 rs705379 C>T polymorphism and increased risk of PCOS in three genetic models: allelic comparison, homozygote comparison and recessive comparison. While the association between PON-1 rs854560 T>A polymorphism and a decreased risk of PCOS was found in dominant model. PON-1 rs662 A>G polymorphism is not correlated with PCOS susceptibil­ity. In summary, this study suggests that PON-1 rs705379 C>T polymorphism may cause an increased risk of PCOS, while PON-1 rs854560 T>A polymorphism may cause a decreased risk of PCOS. © 2016, E-Century Publishing Corporation. All Rights Reserved.

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