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Wang M.,Xinjiang Medical University | Gao F.,The Peoples Hospital of Xinjiang Uyghur Autonomous Region
Chinese Journal of Gastroenterology | Year: 2015

Gastroesophageal reflux disease (GERD) is a commonly seen digestive disease. So far, there is no golden standard for the diagnosis of GERD. The main diagnosis methods used in clinical practice include gastroscopy, 24 h esophageal pH monitoring and proton pump inhibitor test, however, these methods are either invasive or complex in procedure and with low diagnostic accuracy rate. Gastroesophageal reflux disease questionnaire (GerdQ) possesses multiple advantages such as simple, non-invasive and easily acceptable. This article reviewed the use of GerdQ in diagnosis of GERD. COPYRIGHT © 2015 by the Editorial Office of Chinese Journal of Gastroenterology. Source


Eli M.,Xinjiang Medical University | Mollayup A.,The Peoples Hospital of Xinjiang Uyghur Autonomous Region | Muattar,Xinjiang Medical University | Liu C.,Xinjiang Medical University | And 2 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

To investigate the K-ras genetic mutation status in colorectal cancer patients, compare the difference of K-ras genetic mutation rate in Han and Uygur nationality and analyze the influencing factor. 91 cases (52 cases of Han nationality and 39 cases of Uygur nationality) of colorectal biopsy or surgical ablation pathology specimen from the first affiliated hospital of Xinjiang Medical University during January, 2010 to March, 2013 were collected to detect the 12th and 13th code mutation status of K-ras gene exon 2 with pyrosequencing method and compare the difference of K-ras gene mutation rate between Han and Uygur nationality patients. Single factor analysis and multiple factor logistic regression analysis were utilized to analyze the influencing factor for K-ras genetic mutation. 33 cases of patients with K-ras genetic mutation were found from the 91 cases colorectal cancer patients and the total mutation rate was 36.3%. Among them, 24 cases (72.7%) were found with mutation only in the 12th code, 9 cases (27.3%) were found with mutation only in the 13th code and no one case was found with mutation in both the two codes. Mutation rate of the 12th code in the Uygur nationality was significantly higher than that in the Han nationality (P<0.05), but there were no significant difference in the comparison of the total mutation rate and the 13th code mutation rate between the two groups (P>0.05). There were no associativity (P>0.05) between the K-ras genetic mutation and sex, age, smoking history, drinking history, tumor location, macropathology type, differentiation level, staging, invasive depth, lymph nodes transferring and metastasis in colorectal cancer patients (P>0.05). K-ras genetic mutation rate is high in colorectal cancer patients. The mutation rate of 12th code in Uygur nationality is higher than that in Han nationality. There is no significant associativity between K-ras genetic mutation rate and patients’ clinical pathology characteristic. © 2015, E-Century Publishing Corporation. All Rights Reserved. Source


Liang J.,The Peoples Hospital of Xinjiang Uyghur Autonomous Region | Kang X.,The Peoples Hospital of Xinjiang Uyghur Autonomous Region | Halifu Y.,The Peoples Hospital of Xinjiang Uyghur Autonomous Region | Zeng X.,The Peoples Hospital of Xinjiang Uyghur Autonomous Region | And 9 more authors.
BMC Cancer | Year: 2015

Background: The Wnt signaling pathway is abnormally activated in many human cancers. Secreted frizzled-related proteins (SFRPs) function as negative regulators of Wnt signaling and play an important role in carcinogenesis. SFRP promoter hypermethylation has often been identified in human cancers; however, the precise role of SFRPs in cutaneous squamous cell carcinoma (SCC) is unclear. Methods: The methylation status of the SFRP family was analyzed in an age-and sex-matched case-control study, including 40 cutaneous SCC cases and 40 normal controls, using the MassARRAY EpiTYPER system. Results: The methylation rate of SFRP1, SFRP2, SFRP4, and SFRP5 promoters was significantly higher in cutaneous SCC tissues than in adjacent tissue and normal skin samples. Discussion: Our manuscript mainly discussed the average methylation rate of SFRPs (SFRP1, SFRP2, SFRP4, and SFRP5) promoters are significantly high in tumor tissue samples and the average CpG island methylation rate among different pathological levels of cutaneous SCC between these genes are different. Conclusions: Our findings suggest that promoter hypermethylation of SFRPs is associated with the development of carcinoma, and could be a useful tumor marker for cutaneous SCC and other types of cancers. © 2015 Liang et al. Source


Halifu Y.,The Peoples Hospital of Xinjiang Uyghur Autonomous Region | Liang J.Q.,The Peoples Hospital of Xinjiang Uyghur Autonomous Region | Zeng X.W.,The Peoples Hospital of Xinjiang Uyghur Autonomous Region | Ding Y.,The Peoples Hospital of Xinjiang Uyghur Autonomous Region | And 10 more authors.
Genetics and Molecular Research | Year: 2016

The Wnt signaling pathway plays a key role in insurgence and progression of many different forms of cancer. Some crucial components of the Wnt pathway have been proposed to be novel targets for cancer therapy. To date, the Wnt signaling pathway has not been studied in cutaneous squamous cell carcinoma (CSCC). This study was designed to investigate the expression of Wnt1 and SFRP1 from the Wnt pathway in CSCC. Tissue samples were obtained from 35 patients with CSCC and 30 controls admitted to the Xinjiang Uygur Autonomous Region People’s Hospital at Urumchi City, China. Gene and protein expressions of Wnt1 and SFRP1 were quantified by immunohistochemistry and western blotting. Wnt1 expression was significantly higher (P < 0.05) in CSCC samples than in normal skin cells of the control subjects; in contrast, SFRP1 expression was significantly lower in CSCC tissues than that in tissues of control subjects (P < 0.05). Moreover, Wnt1 expression (P < 0.05) was found to be correlated with histopathological differentiation in CSCC, and negatively correlated with SFRP1 expression in CSCC (rs =-0.473, P = 0.015). Therefore, we concluded that Wnt1 and SFRP1 play important roles in the development of CSCC and could be potent markers for diagnosis, prevention, and therapy of CSCC. © FUNPEC-RP. Source


Zhao W.,The Peoples Hospital of Xinjiang Uyghur Autonomous Region | Li M.,The Peoples Hospital of Xinjiang Uyghur Autonomous Region | Wang L.,The Peoples Hospital of Xinjiang Uyghur Autonomous Region | Yuan H.,The Peoples Hospital of Xinjiang Uyghur Autonomous Region
Zhonghua wai ke za zhi [Chinese journal of surgery] | Year: 2015

OBJECTIVE: To study the correlation between the shifting degree of the gravity center position (GCP) and recovering degree of the knee's function of the patients after total knee arthroplasty (TKA) at the same time point.METHODS: One hundred and seventy-six patients who underwent single TKA between June 2012 and December 2013 were measured GCP by corresponding instrument prospectively. Ninety-two patients underwent right knee arthroplasty (25 male and 67 female), eighty-four patients underwent left knee arthroplasty (21 male and 63 female). They were evaluated by Hospital For Special Surgery (HSS) scores pre-operatively, 6-month and 1-year post-operatively, and were measured GCP simultaneously. Pearson's correlation analysis were conducted between shifting degree of GCP and changing degree of HSS score when be compared with pre-operatively.RESULTS: All the patient's HSS score had significantly improved at 6-month and 1-year after surgery than pre-operatively (right knee group: t=-42.82 and -62.46, all P=0.00; left knee group: t=-43.10 and -62.82, all P=0.00). HSS scores had been improved from 51.6 ± 4.2 to 76.6 ± 3.6 and 86.5 ± 3.1 in right knee patients, and improved from 52.2 ± 4.5 to 76.0 ± 3.8, 86.6 ± 2.7 in left knee patients at 6-month and 1-year after surgery. There was a correlation between shifting degree of GCP and changing degree of HSS score 6-month and 1-year after surgery (r=0.424 and 0.139).CONCLUSION: As recovering of the joint function, the weight on operated limb could be increased, thus the GCP moves from its initial position to the operative side after TKA. While, the shifting degree of GCP can be a reflection of recovering of the joint function in some extent. Source

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