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Cheng R.,The Peoples Hospital of Shanxi Province | Nie Q.,Shanxi Agricultural University | Sun H.,Taiyuan Normal University | Zhang Y.,Taiyuan Normal University | And 4 more authors.
Fluoride | Year: 2013

SUMMARY: The purpose of this study was to investigate whether fluoride (F) induces cardiotoxicity in rats and to discuss its underlying mechanisms by detecting morphological change, enzyme activity of oxidative stress, and the expression of Bcl-2 family protein. With increasing dosages of F, obvious pathological changes occurred in the myocardial tissue of rats with a trend to increased expression in the cardiomyocytes of Bax and a trend to decreased expression of Bcl-2. Excessive fluoride caused peroxidation damage with inhibition of the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in myocardial tissue leading to a rise of malonaldehyde (MDA) content. These results indicate that a molecular basis for the cardiac damage by fluoride involves the Bax/ Bcl-2 signalling pathway. © 2013 The International Society for Fluoride Research Inc. Source

Xia L.,Northwest University, China | Chen X.-M.,Northwest University, China | Peng L.-R.,The Central Hospital of Xian | Wang S.-X.,Northwest University, China | And 6 more authors.
Zhongguo Zhongyao Zazhi | Year: 2013

Objective: To investigate the pharmacokinetic effect of Sappan Lignum on hydroxysafflor yellow A (HSYA) in Carthami Flos. Method: Concentration of HSYA in rat plasma was detected by RP-HPLC after rats were orally administered with extracts of Carthami Flos or Carthami Flos combined with Sappan Lignum. Pharmacokinetic parameters were calculated by DAS 2.0 pharmacokinetic software. Result: In vivo pharmacokinetic models of HSYA were two-compartment open models in both of the Carthami Flos group and the Carthami Flos combined with Sappan Lignum group. After compatibility, HSYA showed a significant lower in apparent volumes of distribution of t1/2Ka, t1/2α and V1/F, with slight advance in Tmax. Conclusion: Sappan Lignum can accelerate absorption, distribution and metabolic process of HSYA in vivo and reduce its accumulation in vivo. Source

Jia L.,The Peoples Hospital of Shanxi Province | Ren J.,Shanxi Medical University | Zhang W.,The Peoples Hospital of Shanxi Province | Qi Y.,The Peoples Hospital of Shanxi Province | And 2 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

The aim of this study was to investigate the effects of basic drugs that alkalizes blood, on prognosis of acute lung injury in mice. Mice were randomized into three groups: Group normal saline, Group THAM, injected with 3.64% tri-(hydroxymethyl) methylamine (THAM), and Group NaHCO3, injected with 5% NaHCO3 (n=26, each group). The acute lung injury model was established by intraperitoneal injection of lipopolysaccharide (LPS; 50 mg/kg), followed by infusion of varying concentrations of the above solution into tail vein at the rate of 0.5 ml/h (controlled by micro pump) for over 2 h. Thirty minutes later, 6 mice from each group were randomly selected for blood gas analysis; then, the mice were killed and their lung tissues were sampled for detection of relative indicators, and the remaining mice were observed for signs of mortality for 72 h. Arterial pH, bicarbonate (HCO3 -), and BE and mortality of group THAM and NaHCO3 increased significantly compared to the corresponding parameters of the group normal saline (P<0.05); compared to the group normal saline, group NaHCO3 had increased blood [Na+] and decreased [K+] and [Ca2+] (P<0.05). Blood [Na+] of group THAM decreased while the lactic acid concentration increased (P<0.05) compared to the corresponding values of the group normal saline. Malondialdehyde (MDA) and myeloperoxidase (MPO) activity and wet-to-dry lung weight ratio (W/D) of group THAM and NaHCO3 increased significantly relative to group normal saline (P<0.05). Compared with the biopsy results of (A), pathological biopsy of (B) and (C) clearly revealed alveolar wall thickening, edema of alveolar epithelial cells, and infiltration of large neutrophils. Alkalizing blood could neither inhibit inflammatory reactions in LPS mouse model nor reduce the mortality rate of mice with acute lung injury, while excessive alkalization of blood could increase mice mortality. © 2015, E-Century Publishing Corporation. All rights reserved. Source

Yan J.-P.,The Peoples Hospital of Shanxi Province | Gao Z.-X.,The Peoples Hospital of Shanxi Province | Zhao W.-L.,The Peoples Hospital of Shanxi Province | Zhang C.,The Peoples Hospital of Shanxi Province | Song Q.-M.,The Peoples Hospital of Shanxi Province
Chinese Journal of Interventional Imaging and Therapy | Year: 2012

Objective: To evaluate the efficacy of ultrasound-guided aspiration and sclerotherapy with 50% glucose for treatment of simple cyst in liver and kidney. Methods: Fifty-three patients of 54 symptomatic cysts in liver or kidney were treated with 50% glucose in different way (group I, n=24; group II, n=30), and the efficiencies were compared. The cysts in group I were injected 50% glucose, the total amount of which was 1/3 volume of cyst liquid aspirated. Cysts in group II were treated by modified way, in order to improve the concentration of glucose in cyst as posible, the 50% glucose was injected in to cysts once or many times. The patients were followed up for 6 and 12 months. Results: All cysts were successfully treated in one session. Six months later, the total efficiency for all patients was 81.48% (44/54), of groupI and IIwas 75.00% (18/24) and 86.67% (26/30), respectively. The total efficiency of one year for all patients was 68.52% (37/54), of groupI and II was 58.33% (14/24) and 76.67% (23/30), respectively. There was no difference of diameter and volume between groupIand II before treatment, whereas statistical difference of efficiency was found between them affer treatment (all P<0.05). Conclusion: Ultrasound-guided aspiration and sclerotherapy with 50% glucose is simple, safe and effective for the treatment of simple cysts of kidney and liver, especially for elder patients. Concentration of glucose in cyst is critical to curative effect. Source

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