The Haikou Peoples Hospital of Hainan Province

Haikou, China

The Haikou Peoples Hospital of Hainan Province

Haikou, China
SEARCH FILTERS
Time filter
Source Type

Jiang X.-M.,Fudan University | Zhang J.-B.,Fudan University | Xiong J.,Peoples Hospital of the Xinjiang Uygur Autonomous Region | Huang X.-X.,The Haikou Peoples Hospital of Hainan Province | Ren Z.-G.,Fudan University
Asian Pacific Journal of Cancer Prevention | Year: 2012

Objective: E-cadherin has been identified as a tumor suppressor in many types of carcinoma. However, some studies recently suggested that the role and expression of E-cadherin might be more complex and diverse. In the present study, we evaluated the prognostic value of E-cadherin expression with reference to levels in membranes and cytoplasm, and the membrane/cytoplasm ratio, in hepatocellular carcinomas (HCCs) after curative hepatectomy. Methods: The expression of E-cadherin was assessed by immunohistochemistry in HCC tissue microarrays from 125 patients, and its prognostic values and other clinicopathlogical data were retrospectively analyzed. Patients were followed for a median period of 43.7 months (range 1 to 126 months). Results: Univariate analysis demonstrated that a high membrane/cytoplasm (M/C) ratio of E-cadherin expression was associated with poor overall survival (OS) (P =0.001) and shorter time to recurrence (TTR) (P =0.038), as well as tumor size, intrahepatic metastasis, and TNM stage. In contrast, neither membrane nor cytoplasmic expression of E-cadherin was related with OS and TTR. Furthermore, multivariate analysis confirmed the M/C ratio to be an independent predictor of OS (P =0.031). χ2 tests additionally showed that the M/C ratio of E-cadherin expression was related with early stage recurrence (P =0.012), rather than later stage recurrence. Conclusion: The M/C ratio of E-cadherin expression is a strong predictor of postoperative survival and is associated with early stage recurrence in patients with HCC.

Loading The Haikou Peoples Hospital of Hainan Province collaborators
Loading The Haikou Peoples Hospital of Hainan Province collaborators