Jiang B.-E.,The Peoples Hospital of Dongying City of Shandong Province |
Jiang C.-Q.,Yantaishan Hospital of Yantai City of Shandong Province |
Kang X.-Q.,The Peoples Hospital of Dongying City of Shandong Province |
Jiang S.-Y.,The Peoples Hospital of Dongying City of Shandong Province |
And 2 more authors.
Journal of Biomaterials and Tissue Engineering | Year: 2015
To provide the prolonged and localized drug delivery of ciprofloxacin in the bone trauma induced soft tissue infections, biodegradable implants of ciprofloxacin were prepared. The implants were prepared with two different ratio (90:10; F1 and 50:50; F2) of PLA:PLGA copolymers. The implants were prepared by a simple molding method and characterized for physical evaluations, drug loading, in vitro drug release and in vivo (simulated) antimicrobial activity. The prepared implants were solid, off white matrix structure with smooth texture. The implants showed 92.18±2.02 and 94.98±1.40% drug loading for implant F1 and F2, respectively. The % drug release was found to be 78.15±2.02% for F1 at the end of 7 days; while the formulation F2 released the complete drug (99.98±2.02%) at the end of day 4 itself. In the in vivo (simulated) antimicrobial activity of the implants on the agar plate against Staphylococcus aureus strain and Escherichia coli as compared to that of control F2 showed better antimicrobial activity. At the end of 48 h mean diameters of inhibition zone (MIZ) for Escherichia coli was found to be 4.05 cm and 6.24 cm for the implant F1 and F2, respectively; for the Staphylococcus aureus it was 5.28 cm and 8.02 cm for the implant F1 and F2, respectively. It was concluded that the biodegradable implants prepared from PLA:PLGA (90:10) of ciprofloxacin can be effectively used in the treatment of bone trauma induced bone and soft tissue infection for prolonged period of time. © 2015 American Scientific Publishers. Source