The Pennington Biomedical Research Center

Baton Rouge, LA, United States

The Pennington Biomedical Research Center

Baton Rouge, LA, United States
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SAN DIEGO, CA--(Marketwired - November 16, 2016) - More than three quarters of children in the United States are currently not meeting physical activity recommendations, putting them at an increased risk for obesity, diabetes and related chronic illnesses, according to a report issued today. The 2016 United States Report Card on Physical Activity for Children and Youth was authored by researchers and health experts from organizations across the country that were assembled by the National Physical Activity Plan Alliance. The report shows only 21.6 percent of children ages 6-19 meet U.S. physical activity guidelines. Further, nearly 63 percent of children are getting more than the two hours of screen time per day which exceeds current recommended guidelines. Less than 13 percent of children walk or ride their bike to school, habits that have been associated with lower odds of obesity among children. "Improving the results of the nation's Report Card on physical activity for children and youth will require a multi-pronged, multi-sectoral approach to create a culture that supports and encourages positive movement experiences for children," said Cedric X. Bryant, Ph.D., chief science officer for American Council on Exercise. "ACE is proud to sponsor the Report Card and is committed to promoting the three core values of physical literacy for youth: ability, confidence and a desire to be physically active for life." The World Health Organization and the U.S. Department of Health & Human Services recommend that children and youth engage in a minimum of 60 minutes of moderate-to-vigorous physical activity daily, including vigorous-intensity activity at least three days per week. Four key recommendations to increase physical activity among youth were included in the report: ACE's commitment to youth fitness is deeply integrated within the organization, including these initiatives that can help address the recommendations of the National Physical Activity Plan Alliance: The 2016 United States Report Card on Physical Activity for Children and Youth was released today in conjunction with 37 other countries at the 2016 International Congress on Physical Activity and Public Health in Bangkok, Thailand. This is the second comprehensive assessment of physical activity in U.S. children and youth, updating the first Report Card released in 2014. The Report Card can be downloaded from the National Physical Activity Plan Alliance website ( Further information about the international release of the Report Card can be obtained from the Active Healthy Kids Global Alliance website ( ). The Report Card is produced by the National Physical Activity Plan Alliance's (NPAP) U.S. Report Card Research Advisory Committee. Find more information about the Plan at About ACE: With a mission to get people moving, the nonprofit organization American Council on Exercise (ACE) educates, certifies and represents more than 65,000 currently certified fitness professionals, health coaches and other allied health professionals. ACE advocates for a new intersection of fitness and healthcare, bringing the highly qualified professionals ACE represents into the healthcare continuum so they can contribute to the national solution to physical inactivity and obesity. ACE is the largest certifier in its space and all four of its primary certification programs are accredited by the National Commission for Certifying Agencies (NCCA), the gold standard in the United States for accreditation of certifications that assess professional competence. ACE also plays an important public-service role, conducting and providing science-based research and resources on safe and effective physical activity and sustainable behavior change. For more information, call 800-825-3636 or visit AMERICAN COUNCIL ON EXERCISE, ACE and ACE logos are Registered Trademarks of the American Council on Exercise. About the National Physical Activity Plan Alliance: The NPAPA is a not-for-profit 501-c3 organization committed to ensuring the long-term success of the National Physical Activity Plan (NPAP). A coalition of national organizations and at-large experts on physical activity and public health, they have come together to ensure that efforts to provide physical activity in the American population will be guided by a comprehensive, evidence-based strategic plan. For more information, see About the Pennington Biomedical Research Center: The Pennington Biomedical Research Center is at the forefront of medical discovery as it relates to understanding the triggers of obesity, diabetes, cardiovascular disease, cancer and dementia. It is a campus of Louisiana State University and conducts basic, clinical and population research. The research enterprise at Pennington Biomedical includes approximately 80 faculty and more than 25 post-doctoral fellows who comprise a network of 44 laboratories supported by lab technicians, nurses, dietitians, and support personnel, and 13 highly specialized core service facilities. Pennington Biomedical's more than 500 employees perform research activities in state-of-the-art facilities on the 222-acre campus located in Baton Rouge, Louisiana. For more information, see

Kennedy B.M.,The Pennington Biomedical Research Center | Katzmarzyk P.T.,The Pennington Biomedical Research Center | Johnson W.D.,The Pennington Biomedical Research Center | Johnson G.S.,Southern University and A&M College | And 5 more authors.
Clinical and Translational Science | Year: 2014

The prevention of weight gain to address the obesity epidemic rather than weight loss involves promoting small changes in food choices and physical activity. People United to Sustain Health (PUSH) was designed to increase fruit and vegetable consumption, physical activity, and food security to prevent weight gain in rural adults. Forty-nine participants were randomized into a treatment group which received access to a "Rolling Store," nutrition education and physical activity, and a control group which received family coping classes. Forty-one (84%) of participants completed the study. At the end of 6 months, weight for all participants was maintained from baseline to completion with no significant differences between the groups. The mean fruit consumption over 6 months for the treatment group increased and was significantly greater than change in the control group (p = 0.01). This community-based participatory research study was considered successful because weight gain was prevented. © 2014 Wiley Periodicals, Inc.

Patti G.J.,University of Washington | Tautenhahn R.,Scripps Research Institute | Johannsen D.,The Pennington Biomedical Research Center | Kalisiak E.,Scripps Research Institute | And 5 more authors.
Metabolomics | Year: 2014

The manipulation of distinct signaling pathways and transcription factors has been shown to influence life span in a cell-non-autonomous manner in multicellular model organisms such as Caenorhabditis elegans. These data suggest that coordination of whole-organism aging involves endocrine signaling, however, the molecular identities of such signals have not yet been determined and their potential relevance in humans is unknown. Here we describe a novel metabolomic approach to identify molecules directly associated with extended life span in C. elegans that represent candidate compounds for age-related endocrine signals. To identify metabolic perturbations directly linked to longevity, we developed metabolomic software for meta-analysis that enabled intelligent comparisons of multiple different mutants. Simple pairwise comparisons of long-lived glp-1, daf-2, and isp-1 mutants to their respective controls resulted in more than 11,000 dysregulated metabolite features of statistical significance. By using meta-analysis, we were able to reduce this number to six compounds most likely to be associated with life-span extension. Mass spectrometry-based imaging studies suggested that these metabolites might be localized to C. elegans muscle. We extended the metabolomic analysis to humans by comparing quadricep muscle tissue from young and old individuals and found that two of the same compounds associated with longevity in worms were also altered in human muscle with age. These findings provide candidate compounds that may serve as age-related endocrine signals and implicate muscle as a potential tissue regulating their levels in humans. © 2013 Springer Science+Business Media New York.

Kennedy B.M.,The Pennington Biomedical Research Center | Katzmarzyk P.T.,The Pennington Biomedical Research Center | Johnson W.D.,The Pennington Biomedical Research Center | Griffin W.P.,The Pennington Biomedical Research Center | And 3 more authors.
Clinical and Translational Science | Year: 2013

Introduction: Engaging community residents to obtain their feedback in conducting clinical research, and including them as leaders in implementing applicable health advances is crucial for success and sustaining large center awards. Methods: Forty-four adult men and women participated in one of four focus groups. Two groups each (one African American and one Caucasian) were conducted in Baton Rouge and in New Orleans. Results: In an effort to determine the knowledge, attitudes, and beliefs Louisiana residents have about the Louisiana Clinical and Translational Science (LA CaTS) Center concept, four main themes emerged from focus group participants concerning the state's research institutions, and what it means to have these institutions operating under one umbrella to improve the quality of health of its people: (1) academic/research institutions of the State are uniformly widely recognized and held in high regard; (2) increasing awareness of clinical research is a necessity; (3) establishing the LA CaTS Center is an excellent idea; and (4) effective communication including delivery style is crucial to partnerships and especially to the community. Conclusion: Focus group discussions can provide insight into community residents' perceptions, beliefs, motivations, and patterns of behavior for strategically planning for large center awards. © 2013 Wiley Periodicals, Inc.

PubMed | The Pennington Biomedical Research Center and Xavier University of Louisiana
Type: Journal Article | Journal: The Ochsner journal | Year: 2016

Primary care is a key component of medical care delivery and has a role to play in reducing obesity in the United States. The purpose of this study was to explore attitudes and perceptions about obesity in low-income primary care patients and to identify preferences for weight management interventions from the patient and healthcare provider perspectives.A convenience sample of 28 patients and 6 healthcare providers from across the state of Louisiana participated in 1 of 5 structured focus groups. Demographic information was collected from both the patients and healthcare providers using survey instruments.Patients and healthcare providers were more similar than dissimilar in their perceptions of obesity in that both groups selected referral to a nutritionist, use of medication, and prescribed exercise as the top 3 strategies that would have the greatest impact on losing weight. Referral to a nutritionist was selected as the easiest strategy to implement.Receiving feedback from both patients and healthcare providers gives researchers the opportunity to acquire useful knowledge that may be beneficial in designing and conducting interventions suitable for patients desiring to lose weight, especially those in primary care settings.

PubMed | University of Massachusetts Boston, Boston University, Chromatin, the Pennington Biomedical Research Center and University of Montréal
Type: Journal Article | Journal: The Journal of biological chemistry | Year: 2015

G protein pathway suppressor 2 (GPS2) is a multifunctional protein involved in the regulation of a number of metabolic organs. First identified as part of the NCoR-SMRT corepressor complex, GPS2 is known to play an important role in the nucleus in the regulation of gene transcription and meiotic recombination. In addition, we recently reported a non-transcriptional role of GPS2 as an inhibitor of the proinflammatory TNF pathway in the cytosol. Although this suggests that the control of GPS2 localization may be an important determinant of its molecular functions, a clear understanding of GPS2 differential targeting to specific cellular locations is still lacking. Here we show that a fine balance between protein stabilization and degradation tightly regulates GPS2 nuclear function. Our findings indicate that GPS2 is degraded upon polyubiquitination by the E3 ubiquitin ligase Siah2. Unexpectedly, interaction with the exchange factor TBL1 is required to protect GPS2 from degradation, with methylation of GPS2 by arginine methyltransferase PRMT6 regulating the interaction with TBL1 and inhibiting proteasome-dependent degradation. Overall, our findings indicate that regulation of GPS2 by posttranslational modifications provides an effective strategy for modulating its molecular function within the nuclear compartment.

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