Papakonstantinou C.G.,University of Thessaly |
Balaguru P.N.,Rutgers University |
Auyeung Y.,The Newark Group
Cement and Concrete Composites | Year: 2011
This study investigates the bond behavior of corroded reinforcing steel confined with carbon fiber reinforced polymer (CFRP). Corrosion of steel reinforcement in reinforced concrete structural elements could pose a significant problem that may result in loss of structural capacity and even failure. Very few studies have investigated the performance of the bond in corroded confined specimens. The conclusions from these studies suggest that the confinement prevents the reduction of bond strength even after considerable deterioration. Results reported in this paper provide quantitative information regarding the effectiveness of CFRP confinement. Bond tests were conducted on pull-out specimens with 10, 13, 19, and 25 mm [#3, #4, #6, and #8] diameter steel bars corroded to various levels and confined with CFRP. The primary independent variables investigated were: four bar sizes, various levels of corrosion and number of CFRP layers used for confinement. The results indicate that confinement can be effectively used to prevent the degradation of bond strength even at the highest levels of corrosion (12% mass loss) evaluated in this study. The loss of strength for unconfined specimens reached as high as 80%. As expected, confinement was more effective in bars with larger relative rib area. Confinement was also effective in maintaining the ductility. © 2011 Elsevier Ltd All rights reserved.
Elliott D.J.,Christiana Care Health System |
Elliott D.J.,Christiana Care Value Institute |
Young R.S.,Northwestern University |
Brice J.,The Newark Group |
And 2 more authors.
JAMA Internal Medicine | Year: 2014
IMPORTANCE Hospitalist physicians face increasing pressure to maximize productivity, which may undermine the efficiency and quality of care. OBJECTIVE To determine the association between hospitalist workload and the efficiency and quality of inpatient care. DESIGN, SETTING, AND PARTICIPANTS We conducted a retrospective cohort study of 20 241 admissions of inpatients cared for by a private hospitalist group at a large academic community hospital system between February 1, 2008, and January 31, 2011. EXPOSURES Daily hospitalist workload as measured by relative value units and patient encounters from the hospitalist billing records. MAIN OUTCOMES AND MEASURES The main outcomeswere length of stay (LOS), cost, rapid response team activation, in-hospital mortality, patient satisfaction, and 30-day readmission rates. Key covariates included hospital occupancy and patient-level characteristics. RESULTS The LOS increased as workload increased, particularly at lower hospital occupancy. For hospital occupancies less than 75%, LOS increased from 5.5 to 7.5 days as workload increased. For occupancies of 75%to 85%, LOS increased exponentially above a daily relative value unit of approximately 25 and a census value of approximately 15. At high occupancy (>85%), LOS was J-shaped, with significant increases at higher ranges of workload. After controlling for LOS, cost increased by 111 for each 1-unit increase in relative value unit and 205 for each 1-unit increase in census across the range of values. Changes in workload were not associated with the remaining outcomes. CONCLUSIONS AND RELEVANCE Increasing hospitalistworkload is associated with clinically meaningful increases in LOS and cost. Although our findings should be validated in different clinical settings, our results suggest the need formethods to mitigate the potential negative effects of increased hospitalist workload on the efficiency and cost of care. © 2014 American Medical Association. All rights reserved.
Rosenblat E.,The Newark Group |
Hersh P.S.,The Newark Group
Journal of Cataract and Refractive Surgery | Year: 2016
Purpose To determine intraoperative changes in corneal thickness and outcomes of corneal collagen crosslinking (CXL) using 2 intraoperative regimens: riboflavin-dextran or hypotonic riboflavin. Setting Cornea and refractive surgery practice, Teaneck, New Jersey, USA. Design Prospective randomized case series. Methods Eyes with keratoconus or corneal ectasia were treated. All eyes received preloading with riboflavin 0.1% in 20% dextran. During ultraviolet-A (UVA) exposure, patients were randomly assigned to 1 of 2 study arms; that is, riboflavin-dextran or hypotonic riboflavin. Intraoperative pachymetry was measured before and after the corneal epithelium was removed, after initial riboflavin loading, and after UVA light exposure. Patients were evaluated for maximum keratometry (K), uncorrected distance visual acuity (UDVA), corrected distance visual acuity, corneal thickness, and endothelial cell count (ECC). Results Forty-eight eyes were treated. After removal of the epithelium and riboflavin loading, the mean pachymetry was 430 μm and 432 μm in the standard group and hypotonic group, respectively. Immediately after 30-minute UVA administration, the mean pachymetry was 302 μm and 342 μm, respectively. There was no statistically significant difference in the postoperative maximum K change, UDVA, corneal thickness, or ECC between the 2 groups. Conclusions The cornea thinned substantially during the CXL procedure. The use of hypotonic riboflavin rather than riboflavin-dextran during UVA administration decreased the amount of corneal thinning during the procedure by 30%, from 128 μm to 90 μm. However, there were no significant differences in clinical efficacy or changes in ECC or function between groups postoperatively. In general, corneal thinning during CXL did not seem to compromise the safety of the endothelium. Financial Disclosures Dr. Hersh is a consultant to Avedro, Inc. Dr. Rosenblat has no financial or proprietary interest in any material or method mentioned. © 2016 ASCRS and ESCRS.
Bota M.,University of Southern California |
Talpalaru S.,The Newark Group |
Hintiryan H.,University of Southern California |
Dong H.-W.,University of Southern California |
Swanson L.W.,University of Southern California
Journal of Comparative Neurology | Year: 2014
We describe a novel neuroinformatic platform, the BAMS2 Workspace (http://brancusi1.usc.edu), designed for storing and processing information on gray matter region axonal connections. This de novo constructed module allows registered users to collate their data directly by using a simple and versatile visual interface. It also allows construction and analysis of sets of connections associated with gray matter region nomenclatures from any designated species. The Workspace includes a set of tools allowing the display of data in matrix and networks formats and the uploading of processed information in visual, PDF, CSV, and Excel formats. Finally, the Workspace can be accessed anonymously by third-party systems to create individualized connectivity networks. All features of the BAMS2 Workspace are described in detail and are demonstrated with connectivity reports collated in BAMS and associated with the rat sensory-motor cortex, medial frontal cortex, and amygdalar regions. © 2014 Wiley Periodicals, Inc.
Cooper T.A.,The Newark Group
AIMCAL Web Coating and Handling Conference 2015 | Year: 2015
Flexible packaging, particularly multilayer barrier and pouch packaging, has significant advantages and is expanding rapidly. Flexible packaging is ecologically advantageous due to low use of materials and energy, low carbon footprint and GHG emissions, and reduction in food waste. However, it is still under attack by environmental groups because of difficulty of economic mechanical recycling, so that it presently mostly ends up in landfill. The food, packaging and recycling industries are responding strongly to this attack with programs to educate consumers on sustainability advantages and to obviate landfilling by: Development of new barrier materials and package designs. Development of improved collection, marking and sorting methods. Development of economic new recycling and recovery methods including delamination processes and conversion to energy, fuel and downstream chemicals. Implementation of these various potential routes will depend on local and national logistical, economic and political situations, not just technological factors.
Oliveira N.M.M.,The Newark Group |
Trikha R.,The Newark Group |
McKnight T.,The Newark Group
Retrovirology | Year: 2010
Background: 'Intrinsic' resistance to retroviral infection was first recognised with the Friend virus susceptibility gene (Fv1), which determines susceptibility to murine leukaemia virus (MLV) infection in different murine species. Similarly, the tripartite motif (TRIM) family of proteins determine lentiviral restriction in a primate host-species specific manner. For example rhesus TRIM5α (rhTRIM5α) can potently restrict HIV-1 infection while human TRIM5α (huTRIM5α) only has a mild effect on SIVmac and HIV-1 infectivity (Lv1). Human TRIM5α is able to restrict MLV-N virus replication, but is ineffective against MLV-B or MLV-NB virus infection. Lv2 restriction of some HIV-2 viruses is seen in human cells. Like Lv1, Lv2 is a post-entry restriction factor, whose viral determinants have been mapped to the viral capsid (CA). Unlike Lv1, however, Lv2 is determined by envelope (Env) in addition to CA. Here we present evidence of a novel Env determined post entry restriction to infection in human cells of pseudotyped MLV-B and MLV-NB cores.Results: We generated retroviral vectors pseudotyped with various gamma and lentiviral Envs on MLV-B and -NB CAs containing a green fluorescent protein (GFP) reporter. Flow cytometry was used to determine transduction efficiencies in NP2/CD4/CXCR4 (glioma cell line stably transduced with the HIV receptors) and HeLa/CD4 cell lines. The HeLa/CD4 cell line restricted both MLV CAs in an Env dependent manner, compared to NP2/CD4/CXCR4 cells. Quantitative polymerase chain reaction (QT-PCR) analysis of reverse transcription (RT) transcripts demonstrates that this restriction occurs at a post entry and RT level. siRNA knockdown of huTRIM5α ruled out a direct role for this cellular component in mediating this restriction. We describe a previously unobserved Env determined restriction of MLV-B and MLV-NB CAs in HeLa/CD4 cells when pseudotyped with HIV-2 and RD114 Envs, but not gibbon ape leukaemia virus (GALV), HIV-1 or Amphotrophic (Ampho) Envs.Conclusions: Our data further demonstrate the variability of Env and CA mediated susceptibility to post entry host cell restriction. We discuss the relevance of these findings in light of the growing evidence supporting the complexities involved in innate host immunity to retroviral infection. © 2010 Oliveira et al; licensee BioMed Central Ltd.
The Newark Group | Date: 2013-10-21
The Newark Group | Date: 2013-10-23
The Newark Group | Date: 2014-02-03
A reinforcement support is provided for use in connection with concrete reinforcement elements and poured concrete. The reinforcement support includes a tubular paperboard shell having first and second ends with a channel extending therebetween. At least a first notch is formed into the first end extending towards the second end with the first notch being configured to supportingly accommodate at least one concrete reinforcement element.