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Chen J.-X.,The National Institute of Parasitic Diseases | Chen J.-X.,Collaborating Center for Malaria | Chen M.-X.,The National Institute of Parasitic Diseases | Chen M.-X.,Collaborating Center for Malaria | And 17 more authors.
PLoS ONE | Year: 2013

Fascioliasis is a common parasitic disease in livestock in China. However, human fascioliasis is rarely reported in the country. Here we describe an outbreak of human fascioliasis in Yunnan province. We reviewed the complete clinical records of 29 patients and performed an epidemiological investigation on the general human population and animals in the outbreak locality. Our findings support an outbreak due to Fasciola gigantica with a peak in late November, 2011. The most common symptoms were remittent fever, epigastric tenderness, and hepatalgia. Eosinophilia and tunnel-like lesions in ultrasound imaging in the liver were also commonly seen. Significant improvement of patients' condition was achieved by administration of triclabendazole®. Fasciola spp. were discovered in local cattle (28.6%) and goats (26.0%). Molecular evidence showed a coexistence of F. gigantica and F. hepatica. However, all eggs seen in humans were confirmed to be F. gigantica. Herb (Houttuynia cordata) was most likely the source of infections. Our findings indicate that human fascioliasis is a neglected disease in China. The distribution of triclabendazole®, the only efficacious drug against human fascioliasis, should be promoted. © 2013 Chen et al.


Shin J.-W.,National Cheng Kung University | Chen J.-X.,The National Institute of Parasitic Diseases | Zhang D.-H.,Nanjing Medical University | Lin W.-C.,National Cheng Kung University | And 2 more authors.
Infectious Diseases of Poverty | Year: 2014

To further enhance dialogue and promote cross-strait cooperation in the prevention and control of parasitic diseases, this paper reviewed the progress and current challenges in the cross-strait control and research of parasitic infections, based on three cross-strait meetings on parasitological research in the last decade. The major outcome of the 3rd Meeting of Cross-Strait Parasitological Research held in April 2013 was identifying the research priorities for parasitological research. © 2014 Shin et al.; licensee BioMed Central Ltd.


PubMed | National Cheng Kung University, The National Institute of Parasitic Diseases and Nanjing Medical University
Type: Journal Article | Journal: Infectious diseases of poverty | Year: 2015

To further enhance dialogue and promote cross-strait cooperation in the prevention and control of parasitic diseases, this paper reviewed the progress and current challenges in the cross-strait control and research of parasitic infections, based on three cross-strait meetings on parasitological research in the last decade. The major outcome of the 3rd Meeting of Cross-Strait Parasitological Research held in April 2013 was identifying the research priorities for parasitological research.

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