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Zhao J.,Sichuan University | Huang Z.,Sichuan University | Zeng J.,Sichuan University | Deng M.,Sichuan University | And 3 more authors.
Journal of Inorganic and Organometallic Polymers and Materials | Year: 2012

Magnetic nanoparticles (NPs) of cobalt oxide (Co 3O 4) with the diameter of 20-40 nm have been prepared by a simple liquid deposition method in the Histidine (His) assistance at room temperature. Ethanol plays an important role in the preparation of cobalt oxide NPs with a polycrystalline structure. The growth mechanism for Co 3O 4 cube particles has been preliminarily explained. The hysteresis loop of NPs reveals their good magnetic property indicating that they can be used in hyperthermia, cell separation etc. These applications need the magnetic particles with cytocompatible properties. The analysis of IR spectrum, TG curve and HRTEM image indicated that cobalt oxide particles was conjugated with the His molecules. Escherichia coli (E. coli) and L929 cells tests suggest a good cellular compatibility at a concentration of less than 0.25 mg/mL, indicating that the prepared Co 3O 4 NPs have a potential for several biomedical applications. © 2011 The Author(s).


Yin G.,Sichuan University | Huang Z.,Sichuan University | Deng M.,Sichuan University | Zeng J.,Sichuan University | Gu J.,The Military General Hospital of Chengdu PLA
Journal of Colloid and Interface Science | Year: 2011

Silk fibroin (SF)-coated Fe 3O 4 nanoparticles (NPs) with good superparamagnetism were successfully prepared via a bio-mineralization process at room temperature. Two cell tests revealed that mineralized SF-coated Fe 3O 4 NPs presented good cytocompatibility for L929 and osteoblast cells and higher cell density after 5d with high concentrations of SF-coated Fe 3O 4 NPs (up to 0.5mg/mL). These resulted from SF surface coating on NPs, nano-surface morphology and iron ion release of Fe 3O 4 NPs. The mineralized SF-coated Fe 3O 4 NPs could be envisioned for various bone orthopedic and therapeutic applications, in which SF-coated NPs location is controlled through an external magnetic field to promoted bone growth. © 2011 Elsevier Inc.


Zhao J.,Sichuan University | Deng M.,Sichuan University | Zeng J.,Sichuan University | Huang Z.,Sichuan University | And 4 more authors.
Colloids and Surfaces A: Physicochemical and Engineering Aspects | Year: 2012

In order to obtain magnetic nanoparticles (NPs) coated with small biomolecules, histidine (His)-coated iron oxide (His-Fe 3O 4) and cobalt ferrite (His-CoFe 2O 4) with a polycrystalline structure were prepared by a simple liquid deposition method at room temperature. The growth mechanism for His-Fe 3O 4 and His-CoFe 2O 4 NPs was preliminarily explained, and their growth conditions, such as His concentrations, Co/Fe ratio, the synthesis time, were studied. The analysis of Fourier transform infrared spectra and X-ray photoelectron spectroscopy results indicated that the as-prepared particles were conjugated with the small histidine molecules. The hysteresis loops of NPs revealed their good magnetic property. L929 Cell tests indicate the good cytocompatibility of His-Fe 3O 4 and His-CoFe 2O 4 NPs, which is better than the previous prepared magnetic NPs with the polymer. © 2012 Elsevier B.V.


Wang Y.,Sichuan University | Liao X.,Sichuan University | Huang Z.,Sichuan University | Yin G.,Sichuan University | And 2 more authors.
Colloids and Surfaces A: Physicochemical and Engineering Aspects | Year: 2010

Ni-doped ZnO nanoparticles (NPs) were successfully prepared by bioassisted synthesis technique in the template of silk-fibroin (SF) peptide at room temperature. The dopant Ni ions were incorporated into the wurtzite structure of ZnO crystal. Photoluminescence results of Ni-doped ZnO particles indicated a strong emission band at 410. nm. The field dependence of magnetization measured at room temperature exhibited the good ferromagnetic properties. Bacteriological tests revealed that the prepared Ni-doped ZnO particles with SF peptide had nontoxicity for Staphylococcus aureus and Escherichia coli. © 2010 Elsevier B.V.


Liu J.,Sichuan University | Deng M.,Sichuan University | Huang Z.,Sichuan University | Yin G.,Sichuan University | And 2 more authors.
Colloids and Surfaces B: Biointerfaces | Year: 2013

There is an urgency to prepare non-neurotoxic nanoparticles (NPs) as MRI contrast agent. We prepared ZnFe2O4 NPs with monocrystal structure in the template of silk-fibroin (SF) peptide at room temperature. Analyses of their crystallite size and NPs diameter after the growth of 1d and 8d indicated that SF peptide could promote nucleation, growth and dispersion of NPs. Results of EDS, Raman and TG proved that there was 4wt% of the chemical composition of SF in as-prepared NPs. A possible growth mechanism of ZnFe2O4 NPs in the template of SF is proposed. The saturation magnetizations of NPs with SF (SF-NPs) were about 15 and 30emu/g for 1 and 8 d, respectively. SF-NPs obviously promoted the viability of PC12 cells at NPs concentration of 0.0625mg/mL in 2d and 5d of co-culture. Analysis of neurite length indicated no significant decreases of the experimental groups at different SF-NPs concentrations (from 0.0625 to 0.5mg/mL) after 5d cell co-culture, because SF peptide coating could slow the release of iron/zinc ions from NPs. Furthermore, SF-NPs did not destroy the organelles, karyotheca and the neurite using the observation in the cell ultrathin sections. Based on their good magnetic property and neuro-cytocompatibility, the potential application of ZnFe2O4 NPs with SF as MRI contrast agents would be envisioned. © 2013 Elsevier B.V.

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