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Patent
The Kitasato Institute and Nagase & Co | Date: 2017-03-22

Provided are: a method for producing a mycrosporine-like amino acid (MAA) that includes a step in which microbes are cultivated that produce MAA on the outside of bacterial cells, a step in which the bacterial cells and extracellular culture fluid are separated, and a step in which the MAA is recovered from the extracellular culture fluid; an MAA indicated by formula (1), an MAA produced using this method, or an ultraviolet-absorbing composition including the MAA indicated by formula (1); and a composition including the MAA produced using this method or the MAA indicated by formula (1), for preventing at least one symptom or disease selected from a group comprising acute skin reactions, aging of the skin, and skin cancer.


Patent
The Kitasato Institute, Tokushima University and Nobelpharma Co. | Date: 2015-11-04

The present invention to provide a novel pyruvate dehydrogenase kinase inhibitors. A pyruvate dehydrogenase kinase inhibitor comprising a compound represented by the general formula (I) as an active ingredient (wherein, ring A represents a 6-membered aromatic hydrocarbon ring optionally substituted with 2-4 substituents,R^(1) and R^(4), which are the same or different, represent a hydrogen atom, a hydroxyl group, an optionally substituted C1-6 alkyl group, R^(2) and R^(3), which are the same or different, represent a hydrogen atom, a carboxyl group, an optionally substituted C1-6 alkyl group, an optionally substituted C6-10 aryl group, or a group represented by -C (=R^(9))-R^(10)), a pharmaceutical composition for treatment or prophylaxis of diseases or disorders that pyruvate dehydrogenase kinase relates to its development or aggravation, and a cosmetic composition, and the like.


Patent
Meiji Seika Pharma Co. and The Kitasato Institute | Date: 2013-06-13

An objective of the present invention is to provide novel cyclic depsipeptide derivatives and harmful organism control agents including the same as each other. Specifically, the present invention provides compounds represented by formula (1) or stereoisomers thereof, harmful organism control agents containing them, and a process for producing them.


Patent
The Kitasato Institute and Meiji Seika Pharma Co. | Date: 2013-01-03

Disclosed is a composition for use as a pest control agent, comprising a compound represented by formula (I) or an agriculturally and horticulturally acceptable salt thereof as active ingredient and an agriculturally and horticulturally acceptable carrier:


Patent
The Kitasato Institute and Tokushima University | Date: 2013-12-26

The present invention to provide a novel pyruvate dehydrogenase kinase inhibitors. A pyruvate dehydrogenase kinase inhibitor comprising a compound represented by the general formula (I) as an active ingredient (wherein, ring A represents a 6-membered aromatic hydrocarbon ring optionally substituted with 2-4 substituents,


Patent
The Kitasato Institute and Nippon Chemiphar Co. | Date: 2013-10-15

The present invention relates to a morphinan derivative represented by the following general formula (I), wherein R^(1 )represents hydrogen, C_(1-6 )alkyl, C_(6-10 )aryl, etc., R^(2 )and R^(3), which are the same or different, represent hydrogen, hydroxy, etc., R^(4 )and R^(5 )represent hydrogen, C_(1-6 )alkyl, etc., R^(6 )represents hydrogen, hydroxy, C_(1-6 )alkyl, etc., X represents O or CH_(2), Y represents CO, C(O)O, etc., and m and n, which are the same or different, represent an integer of 0 to 2 (m and n are not 0 at the same time), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof, as well as an analgesic, antianxiety drug, etc. containing the same as an active ingredient.


Patent
The Kitasato Institute and Nippon Chemiphar Co. | Date: 2014-09-10

A morphinan derivative represented by the following general formula (I):^(1) represents hydrogen, C_(1-6) alkyl, cycloalkylalkyl (the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms), aralkyl (the aryl moiety has 6 to 10 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms) and the like,R^(2) represents hydrogen, C_(1-6) alkyl, C_(3-6) cycloalkyl, C_(6-10) aryl, aralkyl (the aryl moiety has 6 to 10 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms) and the like,R^(3), R^(4) and R^(5) represent hydrogen, hydroxy, carbamoyl, C_(1-6) alkoxy, C_(6-10) aryloxy and the like,R^(6a), R^(6b), R^(7), R^(8), R^(9), and R^(10) represent hydrogen and the like,X represents O or CH_(2), andY represents C=O, SO_(2), an atomic bond and the like), or an acid addition salt thereof is used as an analgesic.


Patent
The Kitasato Institute and Nippon Chemiphar Co. | Date: 2016-01-13

The present invention relates to a morphinan derivative represented by the following general formula (I), wherein R^(1) represents hydrogen, C_(1-6) alkyl, C_(6-10) aryl, etc., R^(2) and R^(3), which are the same or different, represent hydrogen, hydroxy, ect., R^(4) and R^(5) represent hydrogen, C_(1-6) alkyl, etc., R^(6) represents hydrogen, hydroxy, C_(1)-_(6) alkyl, etc., X represents O or CH_(2), Y represents C=O, C(=O)O, etc., and m and n, which are the same or different, represent an integer of 0 to 2 (m and n are not 0 at the same time), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof, as well as an analgesic, antianxiety drug, etc. containing the same as an active ingredient.


Patent
The Kitasato Institute and Nagase & Co | Date: 2016-06-22

The present invention provides a novel terpenoid synthetase gene; a method of preparing a terpenoid compound, comprising introducing the novel terpenoid synthetase gene into a host cell to give a transformant, and culturing the transformant; and a novel terpenoid compound.


Patent
The Kitasato Institute | Date: 2014-07-09

[Problem] The present invention addresses the problem of providing an anti-trypanosomal drug having a novel skeleton, in order to solve issues that occur with conventional technologies. [Solution] The present invention is based on the discovery of a microbe that produces an anti-trypanosomal drug having a novel skeleton. Specifically, this invention provides: a compound indicated by formula (I) having a trypanosomal inhibitory activity; an analog thereof; a production method therefor; and a Lechevalieria sp. K10-0216 strain that produces said compound.

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