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Cui X.,The Key Laboratory of Trauma Treatment and Tissue Repair | Cui X.,General Hospital of Guangzhou Military Command | Cheng B.,The Key Laboratory of Trauma Treatment and Tissue Repair | Cheng B.,Guangzhou University of Chinese Medicine | Liu J.,General Hospital of Guangzhou Military Command
Chinese Journal of Tissue Engineering Research

BACKGROUND: Perspiration can remove some metabolites dissolved in the sweat out of the body, playing a supporting role in the excretion. Modern medicine cannot restore the sweat glands of severe trauma or burn patients, and how to solve the regeneration of the skin and sweat glands and culture tissue-engineered skin functional appendage has become a hot spot in today's medical research. OBJECTIVE: To explore the body's metabolism and metabolic way of the sweat, thereby analyzing the functional sweat gland regeneration of tissue-engineered skin. METHODS: Studies addressing the tissue-engineered skin functional appendage regeneration effects on perspiration and metabolism were collected to analyze the body's metabolism and excretion ways, sweat metabolites and metabolism methods, as well as the regeneration of tissue-engineered skin appendages. RESULTS AND CONCLUSION: Sweat as an important member in the excretory system cannot be ignored in maintaining the dynamic equilibrium of the body and preventing the body against metabolite damages. Ideal tissue-engineered skin functional appendages have abilities of sweat secretion, excretion of waste, regulating body temperature and maintaining the dynamic equilibrium of the skin, thereby playing a vital role in skin wound repair and reconstruction after extensive burns. Studies have shown that stem cells and sweat gland cells were co-cultured, and then transplanted into the scar wound for sweat gland reconstruction, which has achieved some success. Source

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