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Zhang B.,The Key Laboratory of Resource Chemistry of Ministry of Education | Zhang B.,Shanghai Normal University | Ren T.-R.,The Key Laboratory of Resource Chemistry of Ministry of Education | Ren T.-R.,Shanghai Normal University | And 4 more authors.
Guocheng Gongcheng Xuebao/The Chinese Journal of Process Engineering | Year: 2011

Silica particles with different morphologies were prepared using cyanobacteria Synechocystis sp. PCC 6803 as a biotemplate via a sol-gel route. The Synechocystis sp. PCC 6803 and as-prepared silica were characterized. The reaction conditions of selective synthesis of monodisperse silica and hollow silica microspheres were established. The formation mechanism of different morphologies was discussed. The results indicated that the silica microspheres had an amorphous structure with an average diameter of 1.5 m, and retained the original morphology of the cells. SiO2 nanoparticles could be uniformly coated on the surface of cells to form the hollow SiO2 microspheres, which had uniform wall thickness and could maintain the original morphology of cells. It was confirmed that the formation mechanisms of SiO2 hollow spheres and SiO2 microparticles were based on the difference between adsorption and penetration.


Wei J.,The Key Laboratory of Resource Chemistry of Ministry of Education | Yu C.,The Key Laboratory of Resource Chemistry of Ministry of Education | Wang L.,The Key Laboratory of Resource Chemistry of Ministry of Education | Wang J.,The Key Laboratory of Resource Chemistry of Ministry of Education | And 3 more authors.
Science China Chemistry | Year: 2015

The mitochondrion is a promising target for diagnosis and therapy. Mitochondrial-targeting silica-coated manganese oxide nanoparticles (MnO@SiO2-PPh3+ NPs) were successfully synthesized to explore the mitochondrial cytotoxicity of nanoparticles. The mitochondrial targeting property was confirmed by a laser scanning confocal microscopy experiment. Even after incubation for only 4 h, the cytotoxicity of MnO@SiO2-PPh3+ NPs against cancer cells was obvious; the ATP content was significantly decreased to 40%; and the mitochondrial membrane potential was depleted. All of these results indicated the collapse of mitochondrial function and the start of a cell apoptosis pathway. Our findings suggest that mitochondrial-mediated © 2015 Science China Press and Springer-Verlag Berlin Heidelberg

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