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The Jordanian Pharmaceutical Manufacturing Co. | Date: 2011-05-11

The present invention relates to a pharmaceutical excipient comprising a mixture of sugar alcohol and chitin and/or chitin derivatives, a method for its preparation and use thereof.

Al Omari M.M.H.,The Jordanian Pharmaceutical Manufacturing Co. | Rashid I.S.,The Jordanian Pharmaceutical Manufacturing Co. | Qinna N.A.,University of Petra | Jaber A.M.,Philadelphia University | Badwan A.A.,The Jordanian Pharmaceutical Manufacturing Co.
Profiles of Drug Substances, Excipients and Related Methodology | Year: 2016

Calcium carbonate is a chemical compound with the formula CaCO3 formed by three main elements: carbon, oxygen, and calcium. It is a common substance found in rocks in all parts of the world (most notably as limestone), and is the main component of shells of marine organisms, snails, coal balls, pearls, and eggshells. CaCO3 exists in different polymorphs, each with specific stability that depends on a diversity of variables. © 2016 Elsevier Inc.

Al Omari M.M.H.,The Jordanian Pharmaceutical Manufacturing Co. | Jaafari D.S.,The Jordanian Pharmaceutical Manufacturing Co. | Al-Sou'od K.A.,Al al-Bayt University | Badwan A.A.,The Jordanian Pharmaceutical Manufacturing Co.
Profiles of Drug Substances, Excipients and Related Methodology | Year: 2014

A comprehensive profile of moxifloxacin HCl with 198 references is reported. A full description including nomenclature, formulae, elemental analysis, and appearance is included. Methods of preparation for moxifloxacin HCl, its intermediates, and derivatives are fully described. In addition, the physical properties, analytical methods, stability, uses and applications, and pharmacology of moxifloxacin HCl are also discussed. © 2014 Elsevier Inc.

Rashid I.,The Jordanian Pharmaceutical Manufacturing Co. | Daraghmeh N.,The Jordanian Pharmaceutical Manufacturing Co. | Daraghmeh N.,University of Greenwich | Al-Remawi M.,The Jordanian Pharmaceutical Manufacturing Co. | And 3 more authors.
Powder Technology | Year: 2010

The influence of the lubricant magnesium stearate (MgSt) on the powder and tablet properties of chitin-Mg silicate coprecipitate was examined and compared with lubricated Avicel® 200 and Avicel-Mg silicate coprecipitate. Crushing strength and disintegration time studies were conducted in order to evaluate tablet properties at different compression pressures. Lubrication of chitin-Mg silicate powder with MgSt was evaluated using a high speed rotary tablet press. The compactability and disintegration time of chitin-Mg silicate are unaffected by the possible deleterious action of up to 2% (w/w) MgSt. The deleterious effect of MgSt on Avicel® 200 compaction was found to be minimized when magnesium silicate was coprecipitated onto Avicel® 200. Lubrication of chitin-Mg silicate with MgSt does not enhance particle agglomeration, whereas the opposite is the case for Avicel® 200; the foregoing was ascertained by measurements of the fixed bulk density, constant powder porosity using Kawakita analysis and by the absence of variation in particle size distribution in the presence of up to 5% (w/w) MgSt. In the case of chitin-Mg silicate tablets the ejection force was greatly reduced at a compression speed of 150,000. tablet/h at a MgSt concentration of 0.5% (w/w). The physical properties and drug dissolution profile of ibuprofen tablets were found to be unaffected when chitin-Mg silicate was lubricated up to 5% (w/w) with MgSt. Optimal drug dissolution was attained for gemfibrozil tablets using 3% (w/w) MgSt when compared to a reference (Lopid tablets). © 2010 Elsevier B.V.

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