Fukui N.,National Hospital Organization Sagamihara Hospital |
Yamane S.,National Hospital Organization Sagamihara Hospital |
Ishida S.,National Hospital Organization Sagamihara Hospital |
Tanaka K.,National Hospital Organization Sagamihara Hospital |
And 3 more authors.
BMC Musculoskeletal Disorders | Year: 2010
Background: Although osteoarthritis (OA) of the knee joints is the most common and debilitating joint disease in developed countries, the factors that determine the severity of symptoms are not yet understood well. Subjects with symptomatic medial knee OA were followed up prospectively to explore the relationship between radiographic changes and symptoms or physical examination findings. Methods. One-hundred six OA knees in 68 subjects (mean age 71.1 years; 85% women) were followed up at 6-month intervals over 36 months. At each visit, knee radiographs were obtained, symptoms were assessed by a validated questionnaire, and the result of physical examination was recorded systematically using a specific chart. Correlations between the change of radiographs and clinical data were investigated in a longitudinal manner. Results. During the study period, the narrowing of joint space width (JSW) was observed in 34 joints (32%). Although those knees were clinically or radiographically indistinguishable at baseline from those without JSW narrowing, differences became apparent at later visits during the follow-up. The subjects with knees that underwent JSW narrowing had severer symptoms, and the symptoms tended to be worse for those with higher rates of narrowing. A significant correlation was not found between the severity of symptoms and the growth of osteophytes. For the knees that did not undergo radiographic progression, the range of motion improved during the follow-up period, possibly due to the reduction of knee pain. Such improvement was not observed with the knees that underwent JSW narrowing or osteophyte growth. Conclusion. The result of this study indicates that the symptoms of knee OA patients tend to be worse when JSW narrowing is underway. This finding may explain, at least partly, a known dissociation between the radiographic stage of OA and the severity of symptoms. © 2010 Fukui et al; licensee BioMed Central Ltd.
PubMed | National Hospital Organization, The Japanese Red Cross College of Nursing, Max Delbrück Center for Molecular Medicine, Yamanashi University and 3 more.
Type: Journal Article | Journal: Molecular cancer therapeutics | Year: 2016
S-phase progression of the cell cycle is accelerated in tumors through various genetic abnormalities, and, thus, pharmacologic inhibition of altered cell-cycle progression would be an effective strategy to control tumors. In the current study, we analyzed the antileukemic activity of three available small molecules targeting CDK4/CDK6 against lymphoid crisis of chronic myeloid leukemia (CML-LC) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL), and found that all three molecules showed specific activities against leukemic cell lines derived from CML-LC and Ph(+) ALL. In particular, PD0332991 exhibited extremely high antileukemic activity against CML-LC and Ph(+) ALL cell lines in the nanomolar range by the induction of G0-G1 arrest and partially cell death through dephosphorylation of pRb and downregulation of the genes that are involved in S-phase transition. As an underlying mechanism for favorable sensitivity to the small molecules targeting CDK4/CDK6, cell-cycle progression of Ph(+) lymphoid leukemia cells was regulated by transcriptional and posttranscriptional modulation of CDK4 as well as Cyclin D2 gene expression under the control of BCR-ABL probably through the PI3K pathway. Consistently, the gene expression level of Cyclin D2 in Ph(+) lymphoid leukemia cells was significantly higher than that in Ph(-) lymphoid leukemia cells. Of note, three Ph(+) ALL cell lines having the T315I mutation also showed sensitivity to PD0332991. In a xenograft model, PD0332991, but not imatinib, suppressed dissemination of Ph(+) ALL having the T315I mutation and prolonged survival, demonstrating that this reagent would be a new therapeutic modality for relapsed CML-LC and Ph(+) ALL patients after treatment with tyrosine kinase inhibitors.
PubMed | Tokyo Medical and Dental University, The Japanese Red Cross College of Nursing, Community General Support Center Senju no sato, Kobe City College of Nursing and 3 more.
Type: | Journal: International journal of nursing practice | Year: 2016
The population of Japan has become multi-cultural, and there is more demand for culturally competent nursing care. The purpose of this study was to explore cultural characteristics of nursing practice in Japan focusing on behaviour. We interviewed 25 professionals with experience in or knowledge of nursing practice both in Japan and either the United States, the United Kingdom, Sweden, Thailand or South Korea. Qualitative content analysis has yielded three themes for cultural characteristics of nursing practice in Japan: practice expectations, communication and relationships with patients. Practice expectations for nurses in Japan involved various aspects; nurses conducted a wide range of basic nursing tasks, including bed baths and toileting. They often relied on non-verbal communication to deliver thoughtfulness and perceptiveness. They typically show deference to doctors and colleagues, emphasizing building and maintaining harmony with them. This emphasis on a multifaceted, non-verbal, and harmonious approach seemed characteristic of practice among Japanese nurses.
Ly B.T.K.,Tokyo Medical University |
Chi H.T.,Tokyo Medical University |
Yamagishi M.,Tokyo Medical University |
Kano Y.,Tochigi Cancer Center |
And 4 more authors.
PLoS ONE | Year: 2013
Acute myeloid leukemia (AML) is a heterogeneous disease characterized by a block in differentiation and uncontrolled proliferation. FLT3 is a commonly mutated gene found in AML patients. In clinical trials, the presence of a FLT3-ITD mutation significantly correlates with an increased risk of relapse and dismal overall survival. Therefore, activated FLT3 is a promising molecular target for AML therapies. In this study, we have shown that green tea polyphenols including (-)-epigallocatechin-3-gallate (EGCG), (-)-epigallocatechin (EGC), and (-)-epicatechin-3-gallate (ECG) suppress the proliferation of AML cells. Interestingly, EGCG, EGC and ECG showed the inhibition of FLT3 expression in cell lines harboring FLT3 mutations. In the THP-1 cells harboring FLT3 wild-type, EGCG showed the suppression of cell proliferation but did not suppress the expression of FLT3 even at the concentration that suppress 100% cell proliferation. Moreover, EGCG-, EGC-and ECG-treated cells showed the suppression of MAPK, AKT and STAT5 phosphorylation. Altogether, we suggest that green tea polyphenols could serve as reagents for treatment or prevention of leukemia harboring FLT3 mutations. © 2013 Ly et al.
Osawa E.,The Japanese Red Cross College of Nursing |
Kodama T.,Japan National Institute of Public Health |
Kundishora E.,Red Cross
AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV | Year: 2010
Community home-based HIV/AIDS programs with care facilitators (CFs) are key interventions for dealing with both the shortage of health professionals (e.g., physicians, nurses, midwives, etc.) and the current HIV/AIDS epidemic in many parts of Africa. Zimbabwe, one of the sub-Saharan countries is not an exception. The Zimbabwe Red Cross Society started a community home-based HIV/AIDS program with CFs in 1992. This paper describes the results of a cross-sectional study conducted to examine the factors influencing the motivational outcome and self-assessed performance of CFs from one province involved in this program. Self-administered questionnaires provided to CFs were analyzed by chi-square test and multiple liner regression. The response rate was 71.7% (15 male, 104 female). Results showed that 46.8% of CFs in rural area had worked more than five years whilst only 18.5% of CFs in urban area did (p< 0.05). The motivational outcome and self-assessed performance of CFs were significantly associated with perception toward family and community environment (β=0.462, SE=0.092, p<0.001 and β=0.496, SE=0.173, p<0.001, respectively) and perception toward organizational characteristics, specially managerial support, like attention from a manager, clear instruction, and goals, had an impact to CFs motivational outcome. These findings suggest that organization need to create the policy consistent with community need and provide clear goal and instruction to improve to motivation and performance of CFs. © 2010 Taylor & Francis.
Kato H.,Hokkaido University |
Watanabe J.,Japan International Cooperation Agency JICA |
Watanabe J.,The Japanese Red Cross College of Nursing |
Nieto I.M.,Hospital Central |
And 2 more authors.
Transactions of the Royal Society of Tropical Medicine and Hygiene | Year: 2011
A molecular epidemiological study was performed using FTA card materials directly sampled from lesions of patients with cutaneous leishmaniasis (CL) in the state of Lara, Venezuela, where causative agents have been identified as Leishmania (Viannia) braziliensis and L. (Leishmania) venezuelensis in previous studies. Of the 17 patients diagnosed with CL, Leishmania spp. were successfully identified in 16 patients based on analysis of the cytochrome b gene and rRNA internal transcribed spacer sequences. Consistent with previous findings, seven of the patients were infected with L. (V.) braziliensis. However, parasites from the other nine patients were genetically identified as L. (L.) mexicana, which differed from results of previous enzymatic and antigenic analyses. These results strongly suggest that L. (L.) venezuelensis is a variant of L. (L.) mexicana and that the classification of L. (L.) venezuelensis should be reconsidered. © 2011 Royal Society of Tropical Medicine and Hygiene.
PubMed | The Japanese Red Cross College of Nursing, Tokyo Medical and Dental University and Miyagi University
Type: Journal Article | Journal: Journal of nursing management | Year: 2016
To determine if nurse managers leadership style is related to Japanese staff nurses affective commitment to their hospital.In Western countries, nurse managers transformational leadership style has been found to increase staff nurses affective commitment to their hospital. However, there are few studies examining this relationship in the context of acute care hospitals in Japan.Staff nurses completed measures of their nurse managers perceived leadership style and factors related to their own affective commitment. The association between affective commitment and perception of leadership style was assessed with multiple logistic regression.Of 736 questionnaires distributed, 579 (78.9%) were returned, and data from 396 (53.8%) fully completed questionnaires were analysed. The intellectual stimulation aspect of transformational leadership positively increased staff nurses affective commitment (odds ratio: 2.23). Nurse managers transactional and laissez-faire leadership styles were not related to affective commitment among staff nurses.The intellectual stimulation aspect of transformational leadership may increase the retention of staff nurses through enhanced affective commitment.To increase staff nurses affective commitment to their hospital, we suggest that hospital administrators equip nurse managers with intellectual stimulation skills.
PubMed | The Japanese Red Cross College of Nursing, Social Welfare Corporation, Kobe University and Tottori University
Type: | Journal: Applied nursing research : ANR | Year: 2016
The purpose of this study was to examine the effectiveness of an exercise class implemented in an area affected by the Great East Japan Earthquake and Tsunami for maintaining and improving physical function and quality of life (QOL) among elderly victims.Participants were 45 elderly disaster victims. To measure the effectiveness of the exercise classes, results on the Functional Reach Test (FRT), Timed Up and Go Test (TUG), One-leg Standing Balance (OSB), and Chair Stand Test (CST) were measured at the beginning of the exercise classes, and after 3 and 6months. In order to assess health-related QOL, the 8-item Short-Form Health Survey (SF-8) was carried out at the beginning of the exercise classes, and after 1, 3, and 6months.Of the 45 people who consented to participate, 27 continued the program for 6months and were used for analysis. Analysis of the results for FRT, OSB, and CST showed significant improvements (respectively, p=.000, .007, and .000). SF-8 showed significant increases for the subscales of bodily pain (p=.004), general health perception (p=.001), and mental health (p=.035).By continuing an exercise program for 6months, improvements were seen in lower limb muscle strength and balance functions. Effectiveness for HRQOL was also observed.
Fukui S.,The Japanese Red Cross College of Nursing
[Nihon kōshū eisei zasshi] Japanese journal of public health | Year: 2013
The aim of this study was to identify the factors associated with the need for health consultation services among non-users of such services within residents of urban public apartment complexes. In December 2011, a cross-sectional mail survey was conducted with the inclusion of 2,000 elderly residents, randomly selected from a total of 6,000 residents. We asked about the need for health consultation services, demographic data, daily living situation, medical and care-giving experiences, and health concerns and desires. Data were analyzed using ordinal logistic regression analyses. A total of 534 questionnaires were analyzed from the 553 respondents (response rate 27.7%). Respondents expressed need for health consultation services: very important 21.5%; important 38.2%; unknown 19.1%; not so much important 14.0%; unimportant 6.9%. The analyses revealed that people with greater need tended to have the following features compared to those with less need: lack of independence in daily activities (P=.03), experiencing stress in family relationships (P=.003), having nurses to consult about health concerns (P=.04), do not necessarily need doctor's consultation regarding their health problems (P<.001), feel it difficult to consult doctors when they have health-related questions (P=.007), know about locally-available health consultation services (P=.02). They also wanted to use services they can visit accompanied by acquaintances (P=.002), with one-on-one health consultation regarding their problems (P=.003), where service is free (P=.008), where they receive advice about their illnesses (P<.001) and about their medical and caregiving cost (P=.008), and maintain contact with others using the services (P<.001). Although the response rate was low, most of residents expressed a need for a health consultation service. Based on the results of this study, a health consultation service provided by nurses may be an effective solution. They also desire the services to be accessible in the company of their acquaintances, provided one-on-one, free of charge, and to provide opportunities not only for consultation concerning their illnesses but also for interaction with others.
Hanley S.J.B.,Hokkaido University |
Yoshioka E.,Hokkaido University |
Yoshioka E.,Asahikawa University |
Ito Y.,The Japanese Red Cross College of Nursing |
And 4 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2014
Background: No studies on male attitudes towards HPV and HPV vaccination have been conducted in Japan, and little is known globally whether attitudes of single fathers differ to those living with a female partner. This exploratory study assessed whether Japanese fathers were likely to have their daughter vaccinated against HPV in a publically funded program and whether any differences existed regarding attitudes and knowledge about HPV according to marital status. Materials and Methods: Subjects were 27 fathers (16 single 11 married) who took part in a study on HPV vaccine acceptability aimed at primary caregivers of girls aged 11-14 yrs in three Japanese cities between July and December 2010. Results: Knowledge about HPV was extremely poor (mean score out of 13 being 2.74±3.22) with only one (3.7%) participant believing he had been infected with HPV and most (81.4%) believing they had no or low future risk. No difference existed regarding knowledge or awareness of HPV according to marital status. Concerning perceived risk for daughters, single fathers were significantly more likely to believe their daughter was at risk for both HPV (87.5% versus 36.4%; p=0.01) and cervical cancer (75.0% versus 27.3%; p=0.02). Acceptability of free HPV vaccination was high at 92% with no difference according to marital status, however single fathers were significantly more likely (p=0.01) to pay when vaccination came at a cost. Concerns specific to single fathers included explaining the sexual nature of HPV and taking a daughter to a gynecologist to be vaccinated. Conclusions: Knowledge about HPV among Japanese fathers is poor, but HPV vaccine acceptability is high and does not differ by marital status. Providing sexual health education in schools that addresses lack of knowledge about HPV as well as information preferences expressed by single fathers, may not only increase HPV vaccine acceptance, but also actively involve men in cervical cancer prevention strategies. However, further large-scale quantitative studies are needed.