The Jackson Laboratory is an independent, nonprofit biomedical research institution, dedicated to contributing to a future of better health care based on the unique genetic makeup of each individual. With more than 1,500 employees in Bar Harbor, Maine, Sacramento, California. and a new genomic medicine institute in Farmington, Connecticut., the Laboratory's mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health. The institution is a National Cancer Institute-designated Cancer Center and has NIH centers of excellence in aging and systems genetics. The Laboratory is also the world's source for more than 7,000 strains of genetically defined mice, is home of the mouse genome database and is an international hub for scientific courses, conferences, training and education. Wikipedia.
The Jackson Laboratory | Date: 2014-06-03
University of Louisville and The Jackson Laboratory | Date: 2013-03-14
Methods and compositions for detecting MusPV, also known as MmuPv1, infection of a rodent subject are described according to aspects of the present invention. In specific aspects, the present invention relates to assays for detecting MusPV infection of a rodent subject; vaccine compositions for inducing an immunological response against MusPV in a rodent subject; methods of inducing an immunological response to MusPV in a rodent subject; isolated MusPV protein; isolated antibodies which specifically binds to an MusPV protein, a fragment or variant thereof; isolated recombinantly expressed MusPV proteins; expression constructs comprising a nucleic acid encoding an MusPV protein; host cells comprising the expression construct; and hybridoma cell lines expressing an anti-MusPV monoclonal antibody specific for MusPV.
The Jackson Laboratory and University of Massachusetts Amherst | Date: 2014-10-10
Described herein are immunodeficient non-human animals lacking expression of toll-like receptor 4 (TLR4) by endogenous autogeneic innate immune cells, as well as methods and compositions for engraftment of xenogeneic hematopoietic stem cells in the immunodeficient non-human animal lacking expression of toll-like receptor 4 (TLR4), thereby creating an innate immune system in the animal derived from the xenogeneic hematopoietic stem cells. Further described are immunodeficient mice lacking expression of toll-like receptor 4 by endogenous autogeneic innate immune cells, as well as methods and compositions for engraftment of xenogeneic hematopoietic stem cells in the immunodeficient mouse lacking expression of toll-like receptor 4, thereby creating an innate immune system in the animal derived from the xenogeneic hematopoietic stem cells.
The Jackson Laboratory | Date: 2015-01-30
The present invention provides methods and systems for efficient and cost-effective provision of mouse colony management services to customers. Described herein is a novel integrated approach to provide a plurality of mouse colony management services by utilizing a common core process shared by the plurality of services.
The Jackson Laboratory | Date: 2014-03-14
The present invention generally relates to uses of glial cell line-derived growth factor (GDNF) in cutaneous wound healing and hair growth. Methods of effecting hair growth and/or wound healing which feature administration of GDNF, or a biologically active fragment thereof, to subjects, e.g., human subject, are disclosed herein. The invention relates also to formulations and kits for achieving the indicated pharmaceutical advantages.