Herzliya Pituah, Israel
Herzliya Pituah, Israel

The Interdisciplinary Center Herzliya is a private academic institution in Israel founded in 1994 by Uriel Reichman. It is located at Herzliya, in the Tel Aviv District and is classified as a non-budgeted academic institution.IDC Herzliya has 6,500 students currently enrolled for undergraduate and graduate degrees, including 1,500 international students from 86 countries around the world.In 2013 the IDC Herzliya was ranked the most successful start-up university in Israel and outside of the United States, ranking #1 in Israel and #21 in the world. In the same year IDC law graduates achieved the highest passing rate at the national bar examination of all Israeli academic institutions. Wikipedia.


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Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: MSCA-NIGHT-2016 | Award Amount: 870.02K | Year: 2016

Following previous TEN years of successful implementation of European Researchers Night in Israel we will have: o Venues covering the whole country. o Involvement of the academic community including Israel Ministry of Science, Technology and Space (MOST), all major research universities, leading collages and three science museums. o Awareness campaign at national level managed and funded by the Israel Ministry of Science, Technology and Space. o Groups of junior-high and high-school students (ages 12-18) will be invited by each partner to take part in each venue. We are ready and proud to implement European Researchers Night 2016 & 2017. All of the partners involved in the project have the experience of running successful European Researchers Nights events. With the successive increase in number of visitors along the years and the reputation of the event we are expecting more than 55,000 visitors each year. Same management as in 2011, 2012, 2013, 2014, 2015 successful events. Proposal covers both 2016 & 2017 European Researchers Night events.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SSH.2013.4.2-1 | Award Amount: 3.22M | Year: 2014

INFOCORE focuses on the conditions that bring about different media roles in the cycle of conflict and peace building. It generates knowledge on (1) the social processes underlying the production of conflict news, and (2) the inherent dynamics of conflict news contents, (3) in a systematically comparative fashion. Based on this perspective, we identify the conditions under which media play specific constructive or destructive roles in preventing, managing, and resolving violent conflict, and building sustainable peace. The project will provide detailed knowledge on the process of conflict news production. Specifically, INFOCORE focuses on interactions between (1) professional journalists (in various media), (2) political actors (including public authorities, military), (3) experts/NGOs (in intelligence, peacekeeping, conflict prevention/resolution, and media assistance), and (4) lay publics (individuals and groups, including economic actors). INFOCORE analyzes these actors different roles (as sources/advocates, mediators, and users/audiences) in the production of (1) professional news media, (2) social media, (3) and semi-public intelligence/expert analysis. To assess the roles of media for shaping lay publics and political actors conflict perceptions and responses to ongoing conflicts, we analyze the dynamics of conflict news content over time. We identify recurrent patterns of information diffusion and the polarization/consolidation of specific frames and determine the main contextual factors that influence the roles media play in conflict and peace building. Specifically, we assess the roles of individual agendas and resources, professional norms, media organizations and systems, political systems, and characteristics of the conflict situation. INFOCORE implements a gender-sensitive perspective throughout the project, contributing to the ECs efforts to enable and strengthen the participation of women in peace and security matters.


Grumbine R.E.,CAS Kunming Institute of Botany | Pandit M.K.,The Interdisciplinary Center
Science | Year: 2013

Ecosystem damage and population resettlements loom, owing to poor planning and impact assessments.


Sham P.C.,The Interdisciplinary Center | Purcell S.M.,Mount Sinai School of Medicine | Purcell S.M.,Harvard University
Nature Reviews Genetics | Year: 2014

Significance testing was developed as an objective method for summarizing statistical evidence for a hypothesis. It has been widely adopted in genetic studies, including genome-wide association studies and, more recently, exome sequencing studies. However, significance testing in both genome-wide and exome-wide studies must adopt stringent significance thresholds to allow multiple testing, and it is useful only when studies have adequate statistical power, which depends on the characteristics of the phenotype and the putative genetic variant, as well as the study design. Here, we review the principles and applications of significance testing and power calculation, including recently proposed gene-based tests for rare variants. © 2014 Macmillan Publishers Limited. All rights reserved.


Eichmann A.,The Interdisciplinary Center
Cold Spring Harbor perspectives in medicine | Year: 2013

The human central nervous system (CNS) features a network of ~400 miles of blood vessels that receives >20% of the body's cardiac output and uses most of its blood glucose. Many human diseases, including stroke, retinopathy, and cancer, are associated with the biology of CNS blood vessels. These vessels originate from extrinsic cell populations, including endothelial cells and pericytes that colonize the CNS and interact with glia and neurons to establish the blood-brain barrier and control cerebrovascular exchanges. Neurovascular interactions also play important roles in adult neurogenic niches, which harbor a unique population of neural stem cells that are intimately associated with blood vessels. We here review the cellular and molecular mechanisms required to establish the CNS vascular network, with a special focus on neurovascular interactions and the functions of vascular endothelial growth factors.


Li M.,The Interdisciplinary Center
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2013

In the standard entropic mechanism adopted in the simple Ekpyrotic models to generate the nearly scale-invariant and Gaussian primordial perturbation, the entropy direction is tachyonically unstable. In this Letter, we consider the stable production of the scale-invariant entropy perturbation in the Ekpyrotic universe via non-minimal couplings. In this model the non-minimally coupled massless scalar field serves as a spectator and is stabilized by the introduced non-minimal couplings. It always corresponds to the entropy field during the contraction and with appropriate couplings can obtain a scale-invariant spectrum. This scenario requires additional mechanisms such as curvaton or modulated preheating to convert the entropy perturbation to the curvature perturbation after the bounce. © 2013 Elsevier B.V.


Li M.,The Interdisciplinary Center
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2014

It is believed that the recent detection of large tensor perturbations strongly favors the inflation scenario in the early universe. This common sense depends on the assumption that Einstein's general relativity is valid at the early universe. In this paper we show that nearly scale-invariant primordial tensor perturbations can be generated during a contracting phase before the radiation dominated epoch if the theory of gravity is modified by the scalar-tensor theory at that time. The scale-invariance protects the tensor perturbations from suppressing at large scales and they may have significant amplitudes to fit BICEP2's result. We construct a model to achieve this purpose and show that the universe can bounce to the hot big bang after long time contraction, and at almost the same time the theory of gravity approaches to general relativity through stabilizing the scalar field. Theoretically, such models are dual to inflation models if we change to the frame in which the theory of gravity is general relativity. Dual models are related by the conformal transformations. With this study we reinforce the point that only the conformal invariant quantities such as the scalar and tensor perturbations are physical. How did the background evolve before the radiation time depends on the frame and has no physical meaning. It is impossible to distinguish different pictures by later time cosmological probes. © 2014 The Author.


Januszewski J.A.,The Interdisciplinary Center | Tykwinski R.R.,The Interdisciplinary Center
Chemical Society Reviews | Year: 2014

Molecules composed of a contiguous sequence of double bonds, the [n]cumulenes, share structural similarities to both of their conjugated relatives, the polyenes and polyynes. The synthesis and properties of [n]cumulenes are, however, quite different from those of either polyenes or polyynes. At an infinite length, [n]cumulenes would provide one structural form of the hypothetical sp-hybridized carbon allotrope carbyne, while shorter derivatives offer model compounds to help to predict the properties of carbyne. Finally, derivatization of the π-electron framework of [n]cumulenes provides a number of different synthetic transformations, with cycloaddition reactions being the most common. In this review, both historical and recent synthetic achievements toward long [n]cumulenes (n ≥ 5) are discussed. This is followed by a description of our current understanding of the physical and electronic structure of [n]cumulenes based on UV/vis spectroscopy and X-ray crystallography. Finally, the reactivity of long [n]cumulenes is described. This journal is © the Partner Organisations 2014.


Raivio T.L.,The Interdisciplinary Center
Biochimica et Biophysica Acta - Molecular Cell Research | Year: 2014

The Cpx envelope stress response (ESR) has been linked to proteins that are integrated into and secreted across the inner membrane for several decades. Initial studies of the cpx locus linked it to alterations in the protein content of both the inner and outer membrane, together with changes in proton motive driven transport and conjugation. Since the mid 1990s, the predominant view of the Cpx envelope stress response has been that it serves to detect and respond to secreted, misfolded proteins in the periplasm. Recent studies in Escherichia coli and other Gram negative organisms highlight a role for the Cpx ESR in specifically responding to perturbations that occur at the inner membrane (IM). It is clear that Cpx adaptation involves a broad suite of changes that encompass many functions in addition to protein folding. Interestingly, recent studies have refocused attention on Cpx-regulated phenotypes that were initially published over 30. years ago, including antibiotic resistance and transport across the IM. In this review I will focus on the insights and models that have arisen from recent studies and that may help explain some of the originally published Cpx phenotypes. Although the molecular nature of the inducing signal for the Cpx ESR remains enigmatic, recently solved structures of signaling proteins are yielding testable models concerning the molecular mechanisms behind signaling. The identification of connections between the Cpx ESR and other stress responses in the cell reveals a complex web of interactions that involves Cpx-regulated expression of other regulators as well as small proteins and sRNAs. This article is part of a Special Issue entitled: Protein trafficking and secretion in bacteria. Guest Editors: Anastassios Economou and Ross Dalbey. © 2013.


Inhibitors of sodium-glucose cotransporters type 2 (SGLT2) are proposed as a novel approach for the management of type 2 diabetes mellitus. SGLT2 cotransporters are responsible for reabsorption of 90 % of the glucose filtered by the kidney. The glucuretic effect resulting from SGLT2 inhibition contributes to reduce hyperglycaemia and also assists weight loss and blood pressure reduction. Several SGLT2 inhibitors are already available in many countries (dapagliflozin, canagliflozin, empagliflozin) and in Japan (ipragliflozin, tofogliflozin). These SGLT2 inhibitors share similar pharmacokinetic characteristics with a rapid oral absorption, a long elimination half-life allowing once-daily administration, an extensive hepatic metabolism mainly via glucuronidation to inactive metabolites and a low renal elimination as a parent drug. Pharmacokinetic parameters are slightly altered in the case of chronic kidney disease (CKD). While no dose adjustment is required in the case of mild CKD, SGLT2 inhibitors may not be used or only at a lower daily dose in patients with moderate CKD. Furthermore, the pharmacodynamic response to SGLT2 inhibitors as assessed by urinary glucose excretion declines with increasing severity of renal impairment as assessed by a reduction in the estimated glomerular filtration rate. Nevertheless, the glucose-lowering efficacy and safety of SGLT2 inhibitors are almost comparable in patients with mild CKD as in patients with normal kidney function. In patients with moderate CKD, the efficacy tends to be dampened and safety concerns may occur. In patients with severe CKD, the use of SGLT2 inhibitors is contraindicated. Thus, prescribing information should be consulted regarding dosage adjustments or restrictions in the case of renal dysfunction for each SGLT2 inhibitor. The clinical impact of SGLT2 inhibitors on renal function and their potential to influence the course of diabetic nephropathy deserve attention because of preliminary favourable results in animal models. © 2015, Springer International Publishing Switzerland.

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