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Mouler Rechtman M.,The Institute of Gastroenterology and Liver Disease | Har-Noy O.,The Institute of Gastroenterology and Liver Disease | Bar-Yishay I.,The Institute of Gastroenterology and Liver Disease | Fishman S.,The Institute of Gastroenterology and Liver Disease | And 4 more authors.
FEBS Letters | Year: 2010

Hepatitis B virus (HBV) infects the liver and uses its cell host for gene expression and propagation. Therefore, targeting host factors essential for HBV gene expression is a potential anti-viral strategy. Here we show that treating HBV expressing cells with the natural phenolic compound curcumin inhibits HBV gene expression and replication. This inhibition is mediated via down-regulation of PGC-1α, a starvation-induced protein that initiates the gluconeogenesis cascade and that has been shown to robustly coactivate HBV transcription. We suggest curcumin as a host targeted therapy for HBV infection that may complement current virus-specific therapies. © 2010 Federation of European Biochemical Societies. Source

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