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Wang Y.,The Institute of Blood Transfusion | Wu Y.,The Institute of Blood Transfusion | Chen Y.,The Institute of Blood Transfusion | Li C.,The Institute of Blood Transfusion | And 3 more authors.
Transfusion | Year: 2016

BACKGROUND: The objective was to analyze and evaluate the effects of strategic measures the Chinese government attempted and undertook throughout the fast-changing and difficult transition periods of the blood service system. STUDY DESIGN AND METHODS: We systematically reviewed data and information regarding policy, blood collection, service system, and clinical transfusion practice, which were the most representative indicators on a national level from 1978 to 2015. RESULTS: Blood donation in China has successfully transitioned from paid donation, then compulsory (but nonremunerated) donation, to voluntary nonremunerated donation. The volume of blood collection has steadily increased from 4,000,000 red blood cell (RBC; 200 mL/unit) units in 1998 to 22,000,000 RBC units in 2014. The percentage of human immunodeficiency virus (HIV) transfusion-transmitted infections in newly diagnosed HIV/AIDS has reduced from 29.6% in 2005 to less than 0.15% in 2013. The use of component therapy has increased from 18% in 1989 to 99% in 2014. CONCLUSIONS: Involvement of the government through enforcement of new statutes and regulations helped improve blood safety and clinical transfusion practice. © 2016 AABB.

Liu X.-H.,The Institute of Blood Transfusion | Chi X.-Y.,The Institute of Blood Transfusion | Jiao S.-X.,The Institute of Blood Transfusion
Chinese Journal of Tissue Engineering Research | Year: 2015

BACKGROUND: The discovery of novel HLA alleles is accelerated by development of molecular biology and applications of numerous new technologies. These new findings not only rich HLA family, but also find a breakthrough point for the study of genetic superiority or disappearance of national gene. OBJECTIVE: To identify two novel HLA-A alleles and to analysis their nucleotide sequences. METHODS: The two samples from two volunteers of Chinese Marrow Donor Program were detected using PCR-SBT and GSSP methods. The HLA-A locus in the two samples were both abnormal genes, and the nucleotide sequence differences were analyzed. RESULTS AND CONCLUSION: The sequences of the samples were different from all alleles in the HLA databases. Sample 1 was found to be different from the closet matching allele A*24:02:01 in one nucleotide substitutions, 360 G > C in exon 3, resulting in amino acid changed from glutamine to histidine at codon 96; and sample 2 differed from A*26:01:01 in one nucleotide substitution, 97 T > C in exon 2, resulting in amino acid changed from tyrosine to histidine at codon 9. The novel alleles were identified and assigned the name HLA-A*24:233 and HLA-A*26:89 officially by the WHO Nomenclature Committee. © 2015 Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.

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