Kapsali M.,The Innovation Group
International Journal of Project Management | Year: 2011
This paper discusses why conventional project management practices lead to the failure of publicly funded innovation deployment projects, and investigates how the use of systems thinking in project management can help projects be more successful. Based on 12 case studies of two EU innovation policies, we provide evidence that by using systemic project management, which entails providing flexibility in planning, communicating and controlling activities, innovation projects are more successful. This research refutes previous theory that claims that we should formalize to manage complexity and uncertainty. The key finding is that systems thinking methods provide the flexibility to manage innovativeness, complexity and uncertainty in innovation projects more successfully. Suggestions for further research include suggestions of how to embed flexibility in project management methods using the constructs of equifinality and causal embeddedness. © 2011 Elsevier Ltd and IPMA.
Kawakami Y.,The Innovation Group
Cell transplantation | Year: 2012
Transplantation of bone marrow (BM) CD34(+) cells, an endothelial/hematopoietic progenitor-enriched cell population, has shown therapeutic efficiency in the treatment of ischemic diseases enhancing neovascularization. However, the number of CD34(+) cells obtained from bone marrow is not sufficient for routine clinical application. To overcome this issue, we developed a more efficient and clinically applicable CD34(+) cell expansion method. Seven-day ex vivo expansion culture of BM CD34(+) cells with a cocktail of five growth factors containing VEGF, SCF, IL-6, Flt-3 ligand, and TPO resulted in reproducible more than 20-fold increase in cell number. The favorable effect of the local transplantation of culture expanded (cEx)-BM CD34(+) cells on rat unhealing fractures was equivalent or higher than that of nonexpanded (fresh) BM CD34(+) cells exhibiting sufficient therapeutic outcome with frequent vasculogenic/osteogenic differentiation of transplanted cEx-BM CD34(+) cells and fresh BM CD34(+) cells as well as intrinsic enhancement of angiogenesis/osteogenesis at the treated fracture sites. Specifically, cEx-BM CD34(+) cell treatment demonstrated the best blood flow recovery at fracture sites compared with the nonexpanded BM CD34(+) cells. In vitro, cEx-BM CD34(+) cells showed higher colony/tube-forming capacity than nonexpanded BM CD34(+) cells. Both cells demonstrated differentiation potential into osteoblasts. Since fresh BM CD34(+) cells can be easily collected from fracture sites at the time of primary operation and stored for future use, autologous cEx-BM CD34(+) cell transplantation would be not only a simple but also a promising therapeutic strategy for unhealing fractures in the field of orthopedic trauma surgery.
Owens D.,The Innovation Group
Communications of the ACM | Year: 2010
Scott S.V.,The Innovation Group |
Orlikowski W.J.,Massachusetts Institute of Technology
Information and Organization | Year: 2013
In responding to Mutch's commentary on sociomateriality (this issue) our aim is to reassert a well-established tradition of plurality in theoretical approaches in information systems and organization research. We challenge his critique by proxy and exclusionary discourse in favour of identifying commonalities and mutuality among theories that explore subtle realism. Further, we maintain that ruling out novel perspectives and stifling innovation is likely to undermine any field of study. If there is a measure of healthy scholarship then it is surely our capacity to sustain the conditions that foster openness and experimentation in the framing and doing of our research endeavors. © 2013 Elsevier Ltd.
The Innovation Group | Date: 2015-08-03
An end cap for a downspout of a gutter system or the like. The end cap has a screen constructed to extend over an opening at a lower end of a downspout. The screen has peripheral edge portions constructed to extend over adjacent outer end portions of the downspout and to be connected thereto by friction, an adhesive, screws or other connectors. The peripheral edge portions may be integral with the screen or may be separate from and connected to the screen.