Neuraltus Pharmaceuticals and The Hospital For Sick Children | Date: 2015-04-01
The present invention provides compositions and methods for treating lysosomal disorders using a class of substituted imidazole derivatives or compounds.
The Hospital For Sick Children | Date: 2015-06-19
The invention provides methods for reducing the incidence and/or severity and/or delaying the onset of heart dysfunction/failure and improving overall survival through the use of remote ischemic per-conditioning and post-conditioning.
The Hospital For Sick Children and Matrix | Date: 2015-06-08
Compositions and methods for modulating the deposition of elastin by administering compositions including insulin receptor agonists are described herein.
The Hospital For Sick Children | Date: 2015-06-02
A method of treating a lysosomal storage disease comprises administering a pyrimethamine derivative to a subject in need thereof.
The Hospital For Sick Children and McMaster University | Date: 2014-04-17
Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.