Portland, OR, United States
Portland, OR, United States

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The present invention relates to a platelet activation device and, more particularly, to a platelet activation device having a multi-channel blood passage, which applies capillary stress to a biological fluid including platelets, thereby activating the platelets included in the blood. The present invention provides an activation structure having multiple microchannels, the structure comprising at least one blood passage, each of which has the same width and comprises multiple bent portions, wherein, while blood successively passes through the multiple bent portions, physical stress is applied to the platelets included in the blood, thereby inducing activation of the platelets, and of the amount of blood is distributed to each blood passage, so as to correspond to the number of blood passages, thereby substantially reducing the number of reciprocating movements of blood and shortening the platelet activation time to a large extent.


Patent
Stealth BioTherapeutics Corporation and The Good | Date: 2016-05-18

The invention provides methods of preventing or treating cardiac ischemia-reperfusion injury in a mammalian subject. The methods provide administering aromatic-cationic peptides in effective amounts to prevent or treat an anatomic zone of no re-flow in mammalian subjects. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof.


Patent
The Good | Date: 2015-08-13

A tool for creating impressions of downhole objects comprising a cylindrical outer casing, a top plate, a plunger, an end plate, a lever, a pressure lock plate, a pressure base, a main spring platform, a main spring, and a plurality of elongated rods. The elongated rods extend from beneath the main spring platform through the pressure lock plate, the pressure base, and the end plate. Each elongated rod is surrounded by a rod spring and a collar. The rod spring extends from the bottom of the pressure base to the collar. The pressure lock plate moves laterally when the lever pivots from a locked to an unlocked position, thereby aligning the plurality of holes in the pressure lock plate with the plurality of holes in the pressure base and enabling the elongated rods to move longitudinally within the tool.


Patent
The Good | Date: 2016-08-04

This invention relates to a patterned substrate for light emitting diode. The patterned substrate includes a surface having a plurality of protrusive structures, wherein each of the protrusive structures includes an upper portion and a lower portion. The surface of the lower portion is a conical surface, and has at least one first zone and at least one second zone. The first zone and the second zone are alternately arranged, wherein the first zone has one or more first projections.


Patent
The Good | Date: 2016-10-12

A spike claw puller for pulling a rail spike includes a handle that defines a through hole that is hole configured to couple to a rail spike pulling machine. A body section defines a top surface and comprises first and second feeder teeth that extend from the handle at a first lift and form a jaw opening therebetween configured to receive the rail spike. First and second feeder extensions extend from the first and second feeder teeth, where the first and second feeder extensions extend beyond a plane that is coplanar with the top surface. The first and second feeder extensions facilitate alignment with the rail spike.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.2.2.1-3 | Award Amount: 8.74M | Year: 2014

Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behavior is seen. This calls for a shift to new approaches. By capitalising on comprehensive longitudinal cohorts, recent advances in genetic, biological, epidemiological, and clinical fields, and combining such interdisciplinary expertise the ACTION consortium will dissect the etiology and pathogenesis of aggression. Based on new insights, ACTION will inform the development of novel diagnostic tools and causative targets and guide the development of treatment and prevention strategies. ACTION is built on interrelated work packages with a focus on a) clinical epidemiology and current classification and treatment problems; b) genetic epidemiology, including Genome Wide Association studies and epigenetics; c) gene-environment correlation and interaction; d) biomarkers and metabolomics. ACTION will deliver an overarching framework that combines a thorough understanding of pathways leading to aggression with a map of current gaps, best practices on clinical, ethical, legal, and social issues. Based on this framework, ACTION will develop novel biomarkers suitable for large-scale applications in children and combine biomarker data with new insights into the effects of gender, age, and comorbidity. ACTION will provide guidance in optimising current intervention programs and deliver new biological targets to pave the way for novel therapeutic interventions. ACTION will provide a decision tree to guide personalised intervention programmes and will have direct and sustained impact on reducing paediatric aggression. Its overarching aim is to reduce aggression by developing approaches that take individual differences in genetic and environmental susceptibility into account, thereby leading to better understanding of personalised intervention programs.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: LCE-04-2015 | Award Amount: 1.99M | Year: 2016

Europes electricity sector is in the midst of major transformation moving from public monopolies to competitive private companies in liberalized markets. The liberalization is expected to increase competition and thus increase cost-efficiency in energy production, transmission and distribution with the result of decreasing electricity prices. The efforts of Member State governments to create a more competitive and sustainable electricity sector are currently clouded by a major economic downturn in Europes economic activity. Such economic hardship often triggers reluctance to change which is becoming visible in particular in the electricity sector, where measures to protect jobs and national industry start to compete with market liberalization. The affordability of sustainable electricity is questioned. There is a strong need for innovative business models for Renewable Energy Source (RES) electricity generation in the long and mid-term because support schemes will fade out in the long term pushing renewables on the market at no marginal costs which then in particular for strongly correlated generation as wind and PV leads to price deterioration during production hours. Already today many Member States have drastically reduced measures to further support the development of the RES sector, so that new investment is not possible without tapping new revenues with new business. The aim of the BestRES project is to identify best practices business models for renewable electricity generation in Europe and to improve these further taking into account new opportunities and synergies coming along with changing market designs in line with the EU target model. Business models investigated in this project shall make use of the aggregation of various renewable sources, storage and flexible demand. The improved business models will be implemented during the project in real-life environments, depending on the market conditions, to proof the soundness of the developed concept.


Patent
The Good | Date: 2016-01-06

A method of selecting source data as part of a process of source data extraction, the method being executed by one or more computer processors and including the steps of: selecting at least a first portion of the source data; and assigning a variable to the first portion of the source data to enable the first portion of the source data to be referred to and extracted using the variable by the one or more computer processors.


Patent
The Good | Date: 2016-01-27

A diagnostic headband has an elongated body with two ends. A mechanism couples the two ends with one another. At least one first lead is coupled with the body. At least one second lead extends from the body. The leads couple with lead pads on the user. An electrical harness is coupled with the body. The electrical harness electrically couples with the at least one first and second leads.


An improved retinoscopy paddle with lens received through openings extending through the paddle member has an axis compass with indicia for assessing the range of refraction error and axis of astigmatism in the eyes of a patient as part of an optical examination. The axis compass may be formed on the paddle member or on a receptacle member adapted for operative receipt on as associated retinoscopy paddle. A method is provided for integrating a retinoscopy paddle and axis compass.

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