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Gu S.-J.,The first peoples Hospital of Xiaoshan District of Hangzhou City | Lu M.,The first peoples Hospital of Xiaoshan District of Hangzhou City | Xuan H.-F.,The first peoples Hospital of Xiaoshan District of Hangzhou City | Chen X.-Z.,The first peoples Hospital of Xiaoshan District of Hangzhou City | And 6 more authors.
Clinica Chimica Acta | Year: 2016

Background: Caspase-cleaved Cytokeratin-18 (CCCK-18) is released during apoptosis. Serum CCCK-18 concentrations are associated with prognosis of some critical illness. We investigated the potential relationships between serum CCCK-18 concentrations and disease severity and long-term clinical outcomes after intracerebral hemorrhage. Methods: Serum CCCK-18 concentrations were determined in a total of 102 patients and 102 controls. Multivariate models were used to predict high concentration of CCCK-18 and 6-month clinical outcomes. The predictive values were evaluated based on areas under receiver operating curve. Results: Compared with controls, serum CCCK-18 concentrations were increased in patients (245.8 ± 108.3 U/l vs. 23.6 ± 18.1 U/l, P< 0.001). National Institute of Health Stroke Scale scores [odds ratio (OR), 1.164; 95% confidence interval (CI), 1.027-1.320; P= 0.003] and hematoma volumes (OR, 1.079; 95% CI, 1.018-1.205; P= 0.008) were independent predictors of high concentration of CCCK-18. CCCK-18 was identified as an independent predictor of 6-month mortality (OR, 1.019; 95% CI, 1.010-1.038; P= 0.013) and 6-month unfavorable outcome (OR, 1.017; 95% CI, 1.008-1.029; P= 0.032) and possessed high predictive values. Conclusion: Increased serum CCCK-18 concentrations are associated with disease severity and clinical outcomes, suggesting that CCCK represent a novel prognostic predictive biomarker after intracerebral hemorrhage. © 2015 Elsevier B.V. Source

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