The First Peoples Hospital of Tianmen City

Jingling, China

The First Peoples Hospital of Tianmen City

Jingling, China
SEARCH FILTERS
Time filter
Source Type

Wei H.,The First Peoples Hospital of Tianmen City | Wei H.,Huazhong University of Science and Technology | Li H.,The First Peoples Hospital of Tianmen City | Wan S.-P.,The First Peoples Hospital of Tianmen City | And 4 more authors.
Medical Science Monitor | Year: 2017

Background: Malvidin (alvidin-3-glucoside) is a polyphenol that belongs to the class of natural anthocyanin, which is abundantly found in red wines, colored fruits, and the skin of red grapes. Therefore, the current investigation was intended to evaluate the effect of malvidin against myocardial infarction induced by isoproterenol in the rats. Material/Methods: The cardioprotective effects was assessed by determining the effect of malvidin on the activities of endogenous antioxidants – catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH) – and on the levels of lipid peroxidation and serum marker enzymes. The serum levels of IL-6 and TNF-a were also determined using an enzyme-linked immunosorbent assay (ELISA) kit. Result: The present study demonstrated a significant cardioprotective effect of malvidin by restoring the defensive activities of endogenous antioxidants – catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH) – and by reducing the levels of lipid peroxidation and serum marker enzymes lactate dehydrogenase (LD) and creatine kinase (CK). Malvidin significantly ameliorated the histopathological changes and impaired mitochondria in the cardiac necrosis stimulated with isoproterenol. Additionally, the results also demonstrated that nuclear translocation of Nrf-2 and subsequent HO-1 expression might be associated with nuclear factor kappa B (NF-kB) pathway activation. Conclusions: Our findings suggest that malvidin exerts cardioprotective effects that might be due to possible strong antioxidant and anti-inflammatory activities. Therefore, this study provides the basis for the development of malvidin as a safe and effective treatment of myocardial infarction. © Med Sci Monit.


Li W.,The First Peoples Hospital of Tianmen City | Liu K.-J.,The First Peoples Hospital of Tianmen City | Song J.-S.,The First Peoples Hospital of Tianmen City | Song R.,The First Peoples Hospital of Tianmen City | Liu Z.-L.,The First Peoples Hospital of Tianmen City
International Journal of Clinical and Experimental Medicine | Year: 2015

Background: RAD51 interacting with BRCA1 and BRCA2 could modulate the penetrance of BRCA1/BRCA2 mutations, which may increase susceptibility for breast cancer by inhibiting DNA repair and genome stability. The purpose of this study was to provide refined statistical evidence for the association between RAD51 polymorphism and breast cancer risk. Design and results: We conducted a meta-analysis of 15 publications with a total of 11,766 cancer cases and 11,227 controls. We summarized the data on the association of RAD51 polymorphism with breast cancer risk and performed subgroup analyses by ethnicity and control source. The pooled ORs based on fixed-effects model did not indicate a modified risk of breast cancer associated with RAD51 polymorphism in the overall population. Nor did we find a significant association in any stratified analysis. Conclusions: This meta-analysis suggested that RAD51 polymorphism did not appear to represent a significant risk factor for breast cancer. © 2015, E-Century Publishing Corporation. All Rights Reserved.

Loading The First Peoples Hospital of Tianmen City collaborators
Loading The First Peoples Hospital of Tianmen City collaborators