The First Peoples Hospital Of Shangqiu City

Shangqiu, China

The First Peoples Hospital Of Shangqiu City

Shangqiu, China
SEARCH FILTERS
Time filter
Source Type

PubMed | Sun Yat Sen University and The First Peoples Hospital of Shangqiu City
Type: Journal Article | Journal: Bioscience reports | Year: 2016

NADH oxidases (NOXs) catalysing the oxidation of NADH to yield NAD


Ji W.,The First Peoples Hospital Of Shangqiu City | Xu L.,East Hospital | Zhou H.,The First Peoples Hospital Of Shangqiu City | Wang S.,The First Peoples Hospital Of Shangqiu City | Fang Y.,The First Peoples Hospital Of Shangqiu City
International Journal of Clinical and Experimental Medicine | Year: 2015

Alzheimer’s disease (AD) is a neurodegenerative disease mostly occurred in the elderly. Genetic mutation is one of well-established risk factors for AD. Several polymorphisms on chromosome 11q were reported to be associated with AD susceptibility. Hence we performed a meta-analysis to systematically assess the association between the most-reported polymorphisms on chromosome 11q (rs10793294, rs7115850, rs7101429, rs4945261, rs2373115, rs670142, rs610932, rs541458 and rs3851179) and AD risk. A comprehensive literature search in the electronic databases was performed to identify all eligible studies. The pooled odds ratios (OR) and 95% confidence intervals (95% CI) were calculated to evaluate the association between 11q variants and AD risk by using the allelic model. Sensitivity analysis was carried out to analyze the influence of single study on the overall results. Begg’s funnel plots and Egger’s test were used to assess the publication biases among studies. All the statistical analyses were conducted by using STATA 12.0 Software (Stata Corp, College Station, TX, USA). A total of 35 eligible articles were included in our meta-analysis. Our data showed that the polymorphism of rs610932 were significantly associated with lower AD risk with a pooled OR of 0.88 (95% CI: 0.84-0.92, P=0.005). The other SNPs of rs494526 (OR=0.83, 95% CI: 0.65-1.00, P<0.001), rs2373115 (OR=0.85, 95% CI: 0.75-0.95, P<0.001) and rs670139 (OR=1.09, 95% CI: 1.05-1.12, P=0.554) were shown to be correlated with lower AD risk. Subgroup analysis revealed a similar result in Caucasians. But only the rs610932 polymorphism was found to be associated with lower AD risk in Asians. The polymorphism of rs610932 was shown to be a risk factor for AD while the other three genetic variants (rs494526, rs2373115 and rs610932) may act as protective factors against AD. © 2015, E-Century Publishing Corporation. All rights reserved.


Xu C.-J.,Zhengzhou University | Xu C.-J.,The First Peoples Hospital Of Shangqiu City | Xu F.,Zhengzhou University
International Journal of Clinical and Experimental Medicine | Year: 2014

Colorectal cancer is one of the most common types of cancer and has a high mortality rate, making accurate prediction of clinical prognosis an important concern. This study sought to investigate the expression of two proteins, MMP-11 and VEGF-C, in colorectal adenocarcinoma tissues to provide options for better tumor detection. The correlation of the expression of these proteins with the clinical and pathological features of colorectal adenocarcinoma and with the invasion and metastasis of colorectal adenocarcinoma were assessed. Immunohistochemistry with light microscopy was used to detect the expression level of MMP-11 and VEGF-C in 78 samples of colorectal adenocarcinoma tissues and in 20 samples of normal colorectal tissues. Expression of MMP-11 in colorectal adenocarcinoma tissues and normal colorectal tissues was detected in 55.1% and 30.0% of samples, respectively; VEGF-C was detected in 78.2% and 15.0% of samples, respectively. The expression of MMP-11 and VEGF-C in colorectal adenocarcinoma tissues were not related to patient age, sex, or tumor location. However, expression was related to Dukes’ staging and lymph node metastasis. Expression of MMP-11 was correlated with distant metastasis from tumors. Lastly, expression of MMP-11 in colorectal adenocarcinoma was positively correlated with VEGF-C. In brief, expression of MMP-11 and VEGF-C in colorectal adenocarcinoma tissues serves as a significant index for evaluating the degree of malignancy, clinical stages, lymph nodes, and distant metastasis of colorectal adenocarcinoma. The detection of both of these proteins may help predict the infiltration, metastasis, and prognosis of colorectal adenocarcinoma, and potentially offers new targets for clinical treatment. © 2014, International Journal of Clinical and Experimental Medicine. All rights reserved.


Liu Q.,The First Peoples Hospital Of Shangqiu City | Cheng L.,The First Peoples Hospital Of Shangqiu City | Wang S.,The First Peoples Hospital Of Shangqiu City
International Journal of Clinical and Experimental Medicine | Year: 2016

Parkinson’s disease (PD) is the most common neurodegenerative disease. Several studies have identified the role of multidrug resistance 1 (MDR1) C3435T genetic polymorphism in PD susceptibility. However, the results still remain inconclusive. The objective of this study was to determine the effect of MDR1 C3435T variant on PD. Eligible case-control articles published between January 2000 and 2016 was searched in the electronic databases. The odds ratio (OR) with its 95% confidence interval (CI) was employed to calculate the strength of effect. A total of ten articles were retrieved, including 5408 participants (2349 PD patients and 3059 controls). No significant between-study heterogeneity was observed, and the fixed-effect model was used. Overall, our meta-analysis revealed that MDR1 C3435T was not associated with increased the risk of PD under each genetic models (P<0.05). Subgroup analysis by ethnicity showed no relevant association in either Asians or Caucasians as well. However, we detected that the mutation rate of TT+CT genotypes of MDR1 C3435T variant with pesticide exposure in PD patients was higher than those of non-exposure, and the statistical analysis detected a significant correlation with increased the risk of PD (TT+CT vs. CC: OR=2.85, 95% CI=1.66-4.90, P=0.0002). No publication bias was found in this meta-analysis. Our results suggested that MDR1 C3435T polymorphism might affect the risk of PD developing only in conjunction with exposure to pesticides. Future well-designed studies with more ethnicities are still needed to further evaluate the effect. © 2016, E-Century Publishing Corporation. All rights reserved.


Zhang X.-L.,The First Peoples Hospital Of Shangqiu City | Cui Y.-H.,The First Peoples Hospital Of Shangqiu City
OncoTargets and Therapy | Year: 2015

Although a number of studies have been conducted on the association between the GSTM1 null genotype and gastric cancer in People’s Republic of China, this association remains elusive and controversial. To clarify the effects of the GSTM1 null genotype on the risk of gastric cancer, an updated meta-analysis was performed in the Chinese population. Related studies were identified from PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM) up to November 5, 2014. A total of 25 studies including 3,491 cases and 5,921 controls were included in this meta-analysis. Overall, a significant association (odds ratio [OR] =1.47, 95% CI: 1.28–1.69) was found between the null GSTM1 and gastric cancer risk when all studies in Chinese population were pooled into the meta-analysis. In subgroup analyses stratified by quality score, geographic area, and source of controls, the same results were observed. Additionally, a significant association was found both in smokers and non-smokers. This meta-analysis showed that the null GSTM1 may be a potential biomarker for gastric cancer risk in Chinese, and further studies with gene–gene and gene–environment interactions are required for definite conclusions. © 2015 Zhang and Cui.


Liu Q.,The First Peoples Hospital Of Shangqiu City | Fang Y.,The First Peoples Hospital Of Shangqiu City
International Journal of Clinical and Experimental Medicine | Year: 2016

Alzheimer’s disease (AD) is the most common type of dementia. Recent genome-wide association studies have identified that PICALM is one of the numerous reproducible AD-associated risk genes, and variants in PICALMare shown to be involved in this disease. However, the results remain conflicting. In this meta-analysis, we searched the online electronic database to retrieve related articles concerning the role of PICALM polymorphisms in AD risk and to systematic reevaluate the exact association. Overall, we screened out ten case-control studies, including 6866 AD patients and 13205 controls. Our results found that A allele of rs3851179 (A vs. G: OR=0.84, 95% CI=0.75-0.94, P=0.002) and C allele of rs541458 (C vs. T: OR=0.85, 95% CI=0.74-0.97, P=0.02) were associated with AD incidence. This significant relationship was also found in GA+AA and AA genotypes of rs3851179, and CC+TC genotype of rs541458 variants (P<0.05). Subgroup analysis by ethnicity showed that rs3851179 variant was genetic factor for AD in Caucasians, while only A allele was associated in Asians; C allele and CC+TC genotype of rs541458 in Caucasians, while no association was found in Asians. For Chinese population, neither these variants was associated with AD risk. In conclusion, our results found that rs3851179 and rs541458 were associated with AD risk. However, more data about other ethnicities with large crowds were needed in the future studies. © 2016, International Journal of Clinical and Experimental Medicine. All rights reserved.


PubMed | The First Peoples Hospital of Shangqiu City
Type: | Journal: OncoTargets and therapy | Year: 2015

Although a number of studies have been conducted on the association between the GSTM1 null genotype and gastric cancer in Peoples Republic of China, this association remains elusive and controversial. To clarify the effects of the GSTM1 null genotype on the risk of gastric cancer, an updated meta-analysis was performed in the Chinese population. Related studies were identified from PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM) up to November 5, 2014. A total of 25 studies including 3,491 cases and 5,921 controls were included in this meta-analysis. Overall, a significant association (odds ratio [OR] =1.47, 95% CI: 1.28-1.69) was found between the null GSTM1 and gastric cancer risk when all studies in Chinese population were pooled into the meta-analysis. In subgroup analyses stratified by quality score, geographic area, and source of controls, the same results were observed. Additionally, a significant association was found both in smokers and non-smokers. This meta-analysis showed that the null GSTM1 may be a potential biomarker for gastric cancer risk in Chinese, and further studies with gene-gene and gene-environment interactions are required for definite conclusions.


PubMed | The First Peoples Hospital of Shangqiu City
Type: | Journal: Biochemical and biophysical research communications | Year: 2016

The liver X receptors (LXRs) are transcriptional regulators of lipid homeostasis and may be critical for neurodegeneration and neurogenesis invivo. However, it remains largely unknown about the role of LXRs and its agonists in the invitro proliferation of neural progenitor cells (NPCs). Here we revealed for the first time that LXRs were markedly expressed in mouse NPCs and were critical for the invitro proliferation. LXR agonists GW3965 and LXR623 promoted the proliferation of wildtype NPCs, but not NPCs from LXR double-knockout mice. Mechanistically, phosphorylation of MEK1/2 and ERK1/2 in NPCs was enhanced upon LXR agonist treatment, while abrogation of MEK/ERK phosphorylation by the inhibitors PD98059 and U0126 impaired the proliferation of wildtype NPCs in the presence or absence of LXR agonists. Collectively, our findings suggest that LXR agonists GW3965 and LXR623 can stimulate the NPC proliferation in LXR- and MEK/ERK-dependent manner.

Loading The First Peoples Hospital Of Shangqiu City collaborators
Loading The First Peoples Hospital Of Shangqiu City collaborators