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Lin D.,Qingdao University | Zhao Y.,The First Peoples Hospital of Lianyungang City | Li H.,Qingdao University | Xing X.,Qingdao University
Journal of Thoracic Disease | Year: 2013

Pulmonary enteric adenocarcinoma, a rare histologic type of primary pulmonary adenocarcinoma with only 16 cases reported to date, has to be differentiated from metastatic colorectal carcinoma. Here we report a case of pulmonary enteric adenocarcinoma which shows villin immunoreactivity in the brush border of tumor cells. As a marker for gastrointestinal adenocarcinoma, villin has been rarely found positive like this pattern in pulmonary adenocarcinomas. This case suggests brush border immunoreactivity of villin is possible in some cases of pulmonary enteric adenocarcinomas. We suggest pathological practitioners pay attention to it. © Pioneer Bioscience Publishing Company.

Qi X.,Subei Peoples Hospital | Qi X.,Nanjing Medical University | Wang K.,The First Peoples Hospital of Lianyungang City | Zhou G.,Subei Peoples Hospital | And 3 more authors.
International Urology and Nephrology | Year: 2016

Purpose: We performed this meta-analysis to evaluate the efficacy and safety of artery preserving versus artery non-preserving in laparoscopic varicocelectomy. Methods: All publications up until October 2015 were searched in PubMed, EMBASE, Ovid, Web of Science, and Cochrane library. Randomized controlled trials (RCTs) and cohort studies (CSs) that compared the difference in two operative approaches in laparoscopic varicocelectomy were included. Statistical analysis was performed using Stata version 12.0. Results: A total of four RCTs and ten CSs involving 503 cases with artery preserving and 911 cases with artery non-preserving met our inclusion criteria. Meta-analysis showed that artery preserving had higher recurrence rate [risk ratio (RR) = 2.91, 95 % confidence interval (CI) 1.83–4.61; P = 0.000], lower incidence of hydrocele formation (RR = 0.18; 95 % CI 0.08–0.42; P = 0.000), and prolonged operating time [standard mean difference (SMD) = 1.27; 95 % CI 0.17–2.37; P = 0.023], compared with artery non-preserving in laparoscopic varicocelectomy. The results were similar in postoperative catch-up growth (RR = 1.00; 95 % CI 0.86–1.17; P = 0.985) and testicular atrophy (RR = 0.36; 95 % CI 0.09–1.54; P = 0.169). Besides, no significant difference was found in sperm concentration, motility, and normal morphology between two groups, as well as on postoperative pregnancy rate (RR = 0.95; 95 % CI 0.65–1.40; P = 0.809). Conclusion: With the advantages of less recurrence, easier operating and less time spending, and comparable results in other respects, artery non-preserving is preferable to artery preserving in laparoscopic varicocelectomy, although there is a relatively high incidence of hydrocele formation. Considering the limitation of included studies, more large-scaled RCTs are required to confirm the present findings. © 2016, Springer Science+Business Media Dordrecht.

Qin X.,Anhui Medical University | Zhang Y.,Peking University | Cai Y.,Guangdong Traditional Chinese Medicine Hospital | He M.,The First Peoples Hospital of Lianyungang City | And 9 more authors.
Clinical Nutrition | Year: 2013

Background & aims: We aimed to examine the prevalence of obesity, abdominal obesity and associated factors in 17,656 Chinese hypertensive adults aged 45-75 years. Methods: A cross-sectional investigation was carried out in Lianyungang, China. Overweight or obesity was defined as a body mass index of ≥25kg/m2. Abdominal obesity was defined as a waist circumference ≥90cm for men and ≥80cm for women. Results: The prevalence of overweight or obesity and abdominal obesity was 54.4% (women 59.3% and men 46.0%) and 59.4% (women 73.8% and men 35.1%), respectively. In the multivariable logistic-regression models, higher hypertension grades and standard of living, greater red meat consumption, lower physical activity levels, and antihypertensive treatment were independently associated with overweight or obesity and abdominal obesity in both sexes. Inland residence (versus coastal) was an independent associated factor for abdominal obesity in both sexes. Furthermore, a positive family history of diabetes in both sexes, a positive family history of hypertension, men with a positive family history of coronary heart disease, and men with inland residence were all independently associated with overweight or obesity. Conclusions: We found a high prevalence of overweight or obesity and abdominal obesity in Chinese hypertensive adults, particularly in inland areas. © 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism.

Zhang X.,The First Peoples Hospital of Lianyungang City | Zhang X.,Nanjing Medical University | Wang J.,Nanjing Medical University | Qian W.,Nanjing Medical University | And 4 more authors.
Neurological Research | Year: 2015

Objective: Dexmedetomidine (DEX) has been implicated in modulating the inflammatory response in central nervous system (CNS). However, the mechanism is still poorly understood. In this study, we evaluate the effects of DEX on lipopolysaccharide (LPS)-induced microglia activation and elucidate its possible signaling pathway involved in its anti-inflammatory effects.Methods: BV2 and primary microglia were pretreated with various concentrations of DEX (0.01, 0.1, 1, and 10 μM) and/or PD98059 for 1 hour, then microglia were incubated with LPS (1 mg/ml) for 24 hours. Nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression were measured by Griess reagent and real-time polymerase chain reaction. Furthermore, two intracellular signaling cascades including extracellular signal-regulated kinase (ERK1/2) and c-Jun N-terminal kinase (JNK) were investigated by western blot analysis.Results: Dexmedetomidine significantly attenuated LPS-induced NO production and iNOS expression in both BV2 cells and primary microglial cells. Lipopolysaccharide activated both ERK1/2 and JNK signal pathways; however, DEX exerted a specific inhibitory effect on ERK1/2 rather than JNK. Intriguingly, treatment of primary microglia and BV2 cells with DEX in combination with ERK1/2 inhibitor (PD98059) enhanced attenuation of LPS-induced NO production and iNOS expression.Discussion: Dexmedetomidine attenuates NO and iNOS accumulation by inhibiting extracellular signalregulated kinase (ERK) activation in both BV2 cells and primary microglial cells. © W. S. Maney & Son Ltd 2015.

Zhang G.,The First Peoples Hospital of Lianyungang City | Wu F.,The First Peoples Hospital of Lianyungang City | Xu Y.,The First Peoples Hospital of Lianyungang City | Feng J.,Chongqing Medical University | And 4 more authors.
Neurological Sciences | Year: 2015

Admission hyperglycemia is thought to be related to poor neurological function and high mortality in patients with spontaneous intracerebral hemorrhage (sICH). However, it is not known whether prestroke glycemic status affects functional outcome of sICH. The study was aimed to disclose the association between prestroke glycemic status and outcome in patients with sICH. The study included 288 patients with sICH. Prestroke glycemic status was represented by hemoglobin A1c (HbA1c) values measured the next day after admission. Correlations between HbA1c and age, hematoma volume, NIHSS, and mRS were analyzed using Spearman’s correlation analysis. Patients were categorized into two groups according to hematoma volume (≤25 mL or >25 mL), mRS values (≤2 or >2), or hematoma location (lobar hematoma or deep hematoma). Logistic regression analyses were used to determine the relative independent risk factors for hematoma volume, hematoma location, and mRS values. In patients with sICH, HbA1c was significantly correlated with hematoma volume, NIHSS, and mRS. High HbA1c levels were independently associated with large hematoma volume, deep ICH, and poor outcome. When patients were stratified by history of diabetes, the predictive effect of HbA1c on outcomes was only observed in patients with diabetes. Admission glucose was also related to hematoma volume, but failed to predict outcome. Although both admission glucose and HbA1c independently predicted hematoma volume in patients with sICH, HbA1c alone could serve as a better predictor of poor outcome in diabetic patients after sICH. © 2015, Springer-Verlag Italia.

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