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Jin C.G.,Kunming Medical University | Zou T.N.,Kunming Medical University | Li J.,Kunming Medical University | Chen X.Q.,Kunming Medical University | And 6 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2015

Side population (SP) cells have stem cell-like properties with a capacity for self-renewal and are resistant to chemotherapy and radiotherapy. Therefore the presence of SP cells in human breast cancer probably has prognostic value. Objective: To investigate the characteristics of SP cells and identify the relationship between the SP cells levels and clinico-pathological parameters of the breast tumor and disease-free survival (DFS) in breast cancer patients. Materials and Methods: A total of 122 eligible breast cancer patients were consecutively recruited from January 1, 2006 to December 31, 2007 at Yunnan Tumor Hospital. All eligible subjects received conventional treatment and were followed up for seven years. Predictors of recurrence and/or metastasis and DFS were analyzed using Cox regression analysis. Human breast cancer cells were also obtained from fresh human breast cancer tissue and cultured by the nucleic acid dye Hoechst33342 with Verapami. Flow cytometry (FCM) was employed to isolate the cells of SP and non-SP types. Results: In this study, SP cells were identified using flow cytometric analysis with Hoechst 33342 dye efflux. Adjusted for age, tumor size, lymph nodal status, histological grade, the Cox model showed a higher risk of recurrence and/or metastasis positively associated with the SP cell level (1.75, 1.02-2.98), as well as with axillary lymph node metastasis (2.99, 1.76-5.09), pathology invasiveness type (1.7, 1.14-2.55), and tumor volume doubling time (TVDT) (1.54, 1.01-2.36). Conclusions: The SP cell level is independently associated with tumor progression and clinical outcome after controlling for other pathological factors. The axillary lymph node status, TVDT and the status of non-invasive or invasive tumor independently predict the prognosis of breast cancer.


PURPOSE:: To determine the 5-year cumulative incidence of pterygium and its associated predictors in the Bai Chinese population in a rural community. METHODS:: This population-based study included 2133 subjects aged 50 years or older in 2010 and was repeated in 2015 with 1520 subjects (71.3%) participating in the follow-up examination. Participants with pterygium in either eye in 2010 were excluded from the analysis related to incidence. Anterior segment examination was performed without pupil dilation using a slit lamp, and pterygium was defined as a raised fleshy triangular fibrovascular tissue growth of the conjunctiva encroaching onto the clear cornea. RESULTS:: The 5-year cumulative incidence of pterygium was 6.8% [95% confidence interval (CI), 5.2–8.4] and was significantly higher in women compared with men (8.8% vs. 3.8%; P = 0.003). The age-specific incidence was 7.7%, 6.5%, and 5.6% in those aged 50–59, 60–69, 70 years, or older at the baseline, respectively. Outdoor occupation was the only predictor, which remained to be significantly associated with a higher incidence of pterygium in multivariate analysis (odds ratio = 2.52, 95% CI, 1.27–4.95). The predictive effect of outdoor occupation on incident pterygium was moderate with an area under the curve in the receiver operating characteristic analysis of 0.59 (95% CI, 0.53–0.66). CONCLUSIONS:: The incidence of pterygium in this rural cohort was higher compared to a previous report in Chinese in urban areas. The findings are important for health policy makers to project future burden of pterygium and make proper decisions on health resource allocation. © 2015 Wolters Kluwer Health, Inc. All rights reserved.


Dou K.,Kunming General Hospital of Chengdu Military Command | Xu Q.,Tianjin Medical University | Han X.,The First Peoples Hospital of Kunming City
Diagnostic Pathology | Year: 2013

Background: Numerous epidemiological studies have been conducted to explore the association between the Lys939Gln polymorphism of Xeroderma pigmentosum group C (XPC) gene and urinary bladder cancer susceptibility. However, the results remain inconclusive. In order to derive a more precise estimation of this relationship, a large and update meta-analysis was performed in this study.Methods: A comprehensive search was conducted through researching MEDLINE, EMBASE, PubMed, Web of Science, China Biomedical Literature database (CBM) and China National Knowledge Infrastructure (CNKI) databases before June 2013. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the association.Results: A total of 12 studies with 4828 cases and 4890 controls for evaluating the XPC Lys939Gln polymorphism and urinary bladder cancer were included. Overall, there was significant associations between the XPC Lys939Gln polymorphism and urinary bladder cancer risk were found for homozygous model (OR = 1.352, 95% CL = 1.088-1.681), heterozygous model (OR = 1.354, 95% CL = 1.085-1.688), and allele comparison (OR = 1.109, 95% CL = 1.013-1.214). In subgroup analysis by ethnicity and source of controls, there were still significant associations detected in some genetic models.Conclusion: Our meta-analysis suggested that the XPC Lys939Gln polymorphism contributed to the risk of urinary bladder cancer.Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1001118393101798. © 2013 Dou et al.; licensee BioMed Central Ltd.


Che Y.H.,The First Peoples Hospital of Kunming City | Chongsuvivatwong V.,Prince of Songkla University | Li L.,The First Peoples Hospital of Kunming City | Sriplung H.,Prince of Songkla University | And 9 more authors.
Public Health | Year: 2016

Objective: To investigate the financial burden of patients who had various stages of hepatitis B virus-related diseases and the level of alleviation from financial burden by health insurance schemes in Yunnan province of China. Study design: A cross-sectional survey. Methods: Patients' information was consecutively recorded at the First Affiliated Hospital of Kunming Medical University, from December 2012 to June 2013. Consecutive cases of hepatitis B virus (HBV) (520), compensated cirrhosis (91), decompensated cirrhosis (198) and hepatocellular carcinoma (HCC) (131) were recruited from the outpatient and inpatient departments. The total direct costs, hospital charge, outpatient costs, hospitalization fees being reimbursed and household catastrophic health expenditure were estimated for each disease group. Results: The average annual direct costs for each disease group were 19,496 RMB for HBV, 28,466 RMB in compensated cirrhosis, 46,061 RMB for decompensated cirrhosis, and 33,044 RMB for HCC patients. Catastrophic health expenditure occurred in all four groups. Health insurance reimbursement released the financial burden incurred by medical expenses of patients under a high level of household economic status. Public health insurance schemes helped the patients to various extents. Conclusions: Among these patient groups, direct costs represent a significant economic burden. Health expenditure and financing systems must be considered to prevent the increase of household catastrophe, particularly among the poor. © 2015 The Royal Society for Public Health.


Ran J.-H.,The First Peoples Hospital of Kunming City | Zhang S.-N.,The First Peoples Hospital of Kunming City | Liu J.,The First Peoples Hospital of Kunming City | Chen Y.-M.,The First Peoples Hospital of Kunming City | And 2 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2016

Introduction: This study was to explore the indications, surgical method, and postoperative treatment of orthotopic liver transplantation (OLT) after hepatic artery (HA) reconstruction with an iliac interposition graft. Methods: This study analyzed in-hospital and follow-up outcomes of 34 Chinese patients: 17 who received conventional OLT (“non-bypass” group) and 17 who received OLT with hepatic artery reconstruction by iliac interposition bypass (“bypass” group). Complications were tracked using findings from clinical presentation, liver function, and HA ultrasound. Results: Compared to the non-bypass group, the bypass group had a longer average surgery time (48.47±11.86 min vs. 82.29±22.00 min, respectively; P < 0.01) and more blood loss (4,841.18±1,268.39 mL vs. 7,047.06±976.04 mL; P < 0.01). The postsurgical hepatic function of both groups quickly recovered and, by 10 days, there was no significant difference in the HA peak blood flow velocity between groups. The bypass patients were followed for an average of 45.2 months (range: 20-56 months), with no arterial-related complications (e.g., artery stenosis or arterial thrombosis) or fatalities. Conclusions: Iliac arterial interpositional graft is an effective and reliable method of HA reconstruction in OLT, when the use of the HA is not possible. © 2016, International Journal of Clinical and Experimental Medicine. All rights reserved.

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