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Tan G.,Nanchang University | Tan G.,University of South China | Huang X.,Nanchang University | Huang X.,The First Peoples Hospital Of Jiujiang City | And 6 more authors.
Neuropsychiatric Disease and Treatment | Year: 2016

Objective: The aim of this study was to use amplitude of low-frequency fluctuation (ALFF) to investigate local features of spontaneous brain activity in patients with congenital comitant strabismus and clarify their relationship with emotional and psychosocial problems. Methods: A total of 20 patients with congenital comitant strabismus (ten males and ten females), and 20 healthy controls (ten males and ten females) closely matched in age, sex, and education underwent resting-state functional magnetic resonance imaging scans. The ALFF method was used to assess local features of spontaneous brain activity. Congenital comitant strabismus patients were distinguished from healthy controls by receiver operating characteristic curve. Correlation analysis was performed to explore the relationships between the observed mean ALFF signal values of the different areas and the Chinese version of the Hospital Anxiety and Depression Scale. Results: Compared with healthy controls, patients with congenital comitant strabismus had significantly lower ALFF in the bilateral medialfrontal gyrus and higher values in the bilateral cerebellum posterior lobe and left angular gyrus. In the congenital comitant strabismus group, the Hospital Anxiety and Depression Scale-depression score showed a negative correlation with the ALFF signal values of the bilateral medial frontal gyrus (r=-0.550, P=0.012) and a negative correlation was noted between the mean ALFF signal values of the left angular gyrus and strabismus duration (r=-0.515, P=0.020). Conclusion: Congenital comitant strabismus mainly involves dysfunction in the bilateral medial frontal gyrus, bilateral cerebellum posterior lobe, and left angular gyrus, which may reflect the underlying pathologic mechanism of congenital strabismus. © 2016 Tan et al.


Tan G.,Nanchang University | Tan G.,University of South China | Huang X.,Nanchang University | Huang X.,The First Peoples Hospital Of Jiujiang City | And 6 more authors.
Neuropsychiatric Disease and Treatment | Year: 2016

Objective: The aim of this study was to evaluate altered spontaneous brain activities in patients with unilateral acute open globe injury (OGI) using amplitude of low-frequency fluctuation (ALFF) method and its relationship with their clinical manifestations. Patients and methods: A total of 18 patients with acute OGI (16 males and two females) and 18 healthy controls (HCs, 16 males and two females) closely matched in age, sex, and education were recruited in this study. The ALFF method was used to evaluate the altered spontaneous brain activities. The relationships between the mean ALFF signal values of different brain regions and the clinical features were evaluated by correlation analysis. Acute OGI patients were distinguished from HCs by receiver operating characteristic curve. Results: Compared with HCs, acute OGI patients had significantly higher ALFF values in the left cuneus, left middle cingulum cortex, and bilateral precuneus. Furthermore, the age of OGI patients showed a negative correlation with the ALFF signal value of the left middle cingulum cortex (r=−0.557, P=0.016) and a negative correlation with the mean ALFF signal value of the bilateral precuneus (r=−0.746, P<,0.001). The ALFF signal value of the bilateral precuneus was negatively correlated with the duration of OGI (r=−0.493, P=0.038) and positively correlated with the vision acuity of the injured eye (r=0.583, P=0.011). Conclusion: Acute OGI mainly induces dysfunction in the left cuneus, left middle cingulum cortex, and bilateral precuneus, which may reflect the underlying pathologic mechanisms of abnormal brain activities in OGI patients. © 2016 Tan et al.


Liu X.-W.,The First Peoples Hospital of Jiujiang City | Zhou D.-H.,The Second Artillery General Hospital Beijing
World Chinese Journal of Digestology | Year: 2014

The liver is the most common and important site of metastases for colorectal cancer, and liver metastasis is one of the important factors leading to treatment failure in colorectal cancer. The traditional methods for treating liver metastases of colorectal cancer (CRLM) are not satisfactory and are often associated with a poor prognosis. High intensity focused ultrasound (HIFU) as a new technique for local ablation of solid tumors not only has advantages of less trauma, fewer complications, faster recovery and definite tumor necrosis, but also can preserve and enhance the host anti-tumor immunity. In recent years, HIFU ablation has been increasingly used for the therapy of tumors in clinical settings. This paper gives an overview of mechanisms of action and application status of HIFU in the treatment of colorectal cancer liver metastases, and explores current challenges and future perspectives. © 2014 Baishideng Publishing Group Co., Limited. All rights reserved.


Huang X.,Nanchang University | Huang X.,The First Peoples Hospital Of Jiujiang City | Li S.-H.,Nanchang University | Zhou F.-Q.,Nanchang University | And 5 more authors.
Neuropsychiatric Disease and Treatment | Year: 2016

Objective: To investigate the underlying regional homogeneity (ReHo) of brain-activity abnormalities in patients with comitant strabismus (CS) and their relationship with behavioral performance. Methods: Twenty patients with CS (ten men and ten women) and 20 (ten men and ten women) age-, sex-, and education-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging scans. The ReHo method was used to assess local features of spontaneous brain activities. Patients with CS were distinguished from HCs by receiver operating characteristic curve. Correlation analysis was performed to explore the relationship between the observed mean ReHo values of the different brain areas and behavioral performance. Results: Compared to HCs, the patients with CS showed significantly increased ReHo values in the right inferior temporal cortex/fusiform gyrus/cerebellum anterior lobe, right lingual gyrus, and bilateral cingulate gyrus. We did not find any relationship between the observed mean ReHo values of the different brain areas and behavioral performance. Conclusion: CS causes dysfunction in many brain regions, which may explain the fusion compensation in CS. © 2016 Huang et al.


Huang X.,Nanchang University | Huang X.,The First Peoples Hospital Of Jiujiang City | Li H.-J.,Nanchang University | Zhang Y.,Nanchang University | And 5 more authors.
Neuropsychiatric Disease and Treatment | Year: 2016

Objective: The aim of this study was to investigate the fractional anisotropy (FA) and mean diffusivity (MD) using a diffusion tensor imaging technique and whole-brain voxel-based analysis in patients with comitant strabismus. Patients and methods: A total of 19 (nine males and ten females) patients with comitant strabismus and 19 age-, sex-, and education-matched healthy controls (HCs) underwent magnetic resonance imaging examination. Imaging data were analyzed using two-sample t-tests to identify group differences in FA and MD values. Patients with comitant strabismus were distinguishable from HCs by receiver operating characteristic curves. Results: Compared with HCs, patients with comitant strabismus exhibited significantly decreased FA values in the brain regions of the left superior temporal gyrus and increased values in the bilateral medial frontal gyrus, right globus pallidus/brainstem, and bilateral precuneus. Meanwhile, MD value was significantly reduced in the brain regions of the bilateral cerebellum posterior lobe and left middle frontal gyrus but increased in the brain regions of the right middle frontal gyrus and left anterior cingulate. Conclusion: These results suggest significant brain abnormalities in comitant strabismus, which may underlie the pathologic mechanisms of fusion defects and ocular motility disorders in patients with comitant strabismus. © 2016 Huang et al.


Huang X.,Nanchang University | Huang X.,The First Peoples Hospital Of Jiujiang City | Li H.-J.,Nanchang University | Ye L.,Nanchang University | And 5 more authors.
Neuropsychiatric Disease and Treatment | Year: 2016

Objective: To investigate the underlying regional homogeneity (ReHo) brain activity changes in patients with unilateral acute open-globe injury (OGI) and their relationship with their clinical features. Patients and methods: In total, 18 patients with acute OGI (16 males and two females) and 18 healthy controls (HCs; 16 males and two females) closely matched in age, sex, and education status participated in the study. Each subject underwent a resting-state functional magnetic resonance imaging scan. The ReHo method was used to assess local features of spontaneous brain activity. Receiver-operating characteristic curve was used to distinguish OGIs from HCs. The nonparametric statistical analysis was used to explore the relationship between the observed mean ReHo values of the different brain areas and the behavioral performance. Results: Compared with HCs, acute OGI patients had significantly increased ReHo values in the right cerebellum posterior lobe/lingual gyrus, left superior temporal gyrus/inferior frontal gyrus, left inferior frontal gyrus, left posterior cingulate cortex/precuneus, and left precentral operculum. However, there was no relationship between the observed mean ReHo values of the different brain areas and the behavioral performance. Conclusion: Acute OGI may cause dysfunction in many brain regions, which may reflect the underlying pathologic mechanisms of acute vision loss in OGI patients. © 2016 Huang et al.


Huang X.,Nanchang University | Huang X.,The First Peoples Hospital Of Jiujiang City | Zhang Q.,Nanchang University | Hu P.-H.,Nanchang University | And 5 more authors.
Medical Science Monitor | Year: 2016

Background: The aim of this study was to investigate potential morphological alterations of gray and white matter in patients with optic neuritis (ON) and their relationship with behavioral performance, using voxel-based morphometry (VBM). Material/Methods: Twelve (4 males, 8 females) patients with ON and 12 (4 males, 8 females) age-, sex-, and education-matched healthy controls (HCs) underwent magnetic resonance imaging (MRI). Imaging data were analyzed using twosample t tests to identify group differences in gray and white matter volume (GMV, WMV). Correlation analysis was used to explore relationships between observed GMV and WMV of different areas and visual evoked potential (VEP) in ON. Results: Compared with HCs, ON patients had: significantly decreased GMV in the left postcentral gyrus, left inferior frontal gyrus, left anterior cingulate, left and right middle frontal gyrus, and right inferior parietal lobule; decreased WMV in the left middle frontal gyrus, right superior frontal gyrus, left precentral gyrus and right inferior parietal lobule; and increased WMV in the left fusiform gyrus and left inferior parietal lobule. VEP latency of the right eye in ON correlated positively with WMV signal value of the left fusiform gyrus (r=0.726, p=0.008), and negatively with GMV signal value of the right inferior parietal lobule (r=–0.611, p=0.035). Duration of ON correlated negatively with WMV signal value of the right superior frontal gyrus (r=–0.662, p=0.019), while bestcorrected visual acuity (VA) of the right eye correlated negatively with WMV signal value of the left middle frontal gyrus (r=–0.704, p=0.011). Conclusions: These results suggest significant brain involvement in ON, which may reflect the underlying pathologic mechanism. Correlational results demonstrate that VEP in ON is closely associated with WMV and GMV atrophy in many brain regions. © Med Sci Monit.


Qu X.-Y.,The First Peoples Hospital of Jiujiang City | He J.,The First Peoples Hospital of Jiujiang City | Xie P.,The First Peoples Hospital of Jiujiang City
International Eye Science | Year: 2014

AIM: To observe the application of anterior chamber air in avoiding hyphema after operation of small incision extracapsular cataract extraction (ECCE) and intraocular lens (IOL). METHODS: We retrospectively analyzed 25 patients who were performed anterior chamber air before the finish of surgery to keep intraocular hypertension temporarily so as to avoid hyphema after operation of small incision ECCE and IOL. RESULTS: There were 2 cases hyphema out of 25 patients. The air in the anterior chamber was absorbed in 2-5d after surgery. CONCLUSION: The application of anterior chamber air can avoid hyphema after operation of small incision ECCE and IOL.

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