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Sun L.-J.,The Affiliated Hospital of Jining Medical College | Zhang L.-H.,The First Peoples Hospital of Jining City | Wang L.-S.,The Affiliated Hospital of Jining Medical College
Journal of Practical Oncology | Year: 2015

Objective: To review the CT and MRI findings of adrenal adenoma containing ectocytic fat. Methods: Seven patients with adrenal adenoma containing ectocytic fat underwent non-enhanced and enhanced CT scan and 4 of them also underwent non-enhanced MRI examination. Clinical data and imaging findings of 7 patients were retrospectively reviewed. Results: Seven cases all had dominant non-fat components. Fatty foci were multiple (3~8) with diameters of 1.4~7.2 mm. CT values of fatty foci were -110~-46 HU, while CT values of non-fat components were 5.8~13.4 HU. There were calcifications near fatty foci in 5 cases. All cases enhanced heterogeneously. Greatly-enhanced nodules near fatty foci were detected in 4 cases, tumor arteries and veins were dilated in one case. Fatty foci were hypointense on fat-suppressed T1WI while hyperintense on non-fat-suppressed T1WI. The non-fat components of 4 cases showed high signal on the in-phase T1WI with signal dropout on the out-of-phase T1WI. Conclusion: Adrenal adenoma containing ectocytic fat has some characteristics on CT and MRI scanning. Imaging features of non-fat components are helpful for qualitative and differential diagnosis of the tumor. © 2015, Journal of Practical Oncology, Editorial Board. All right reserved. Source

Guo L.-Y.,Jining Medical University | Zhang S.,The First Peoples Hospital of Jining City | Suo Z.,Ankang hospital of Shandong province | Yang C.-S.,Jining Medical University | And 5 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2015

Objective: To study the PLCE1 gene rs2274223 polymorphism with regard to esophageal cancer and its interaction with diet, lifestyle, psychological and environmental factors in Southwest Shandong province. Materials and Methods: A case series study (case-case) was conducted. Questionnaire data were collected and 3 ml-5ml venous blood was drawn for DNA extraction among the qualified research subjects. PLCE1 gene polymorphism was detected after PCR amplification of DNA. SPSS 13.0 software was used for statistical analysis of the data. Results: The three genotypes A/A, A/G and G/G PLCE1 gene rs2274223 was 31, 16 and 4 cases, accounting for 60.8%, 31.4%, 0.08% respectively. The difference of three genotypes (AA/GA/GG) proportion between negative and positive family history of patients was statistically significant, χ2=6.213, p=0.045. There was no statistically significant relationship between PLCE1 gene rs2274223 polymorphism and smoking, drinking, χ2=0.119, p=0.998, and χ2=1.727, p=0.786. There was no linkage of the three rs2274223 PLCE1 gene genotypes (AA/GA/GG) proportion with eating fried, pickled, hot, mildew, overnight, smoked, excitant food, eat speed, salt taste or not (p>0.05). or with living environment pollution and nine risk factors of occupational exposure (p>0.05). There was no statistically significant difference in TS scores between different genotype of rs2274223 PLCE1 gene. Conclusions: The PLCE1 rs2274223 polymorphism has a relationship with family history of esophageal cancer, but does not have any significant association with age, gender, smoking, alcohol drinking, food hygiene, eating habits, living around the environment and occupation in cases. Source

Liu Z.-Y.,The First Peoples Hospital of Jining City | Zhang C.,The First Peoples Hospital of Jining City | Zhang L.,Shandong University
World Chinese Journal of Digestology | Year: 2016

AIM: To detect the expression of somatostafin receptor subtype 2 (SSTR2) in human colorectal neuroendocrine neoplasms and analyze its clinicopathological significance. METHODS: Clinical samples and clinicopathological information of patients with colorectal neuroendocrine neoplasms were collected. The expression of SSTR2 in tumor tissues was examined by immunohistochemical EnVision method. RESULTS: A total of 56 patients were enrolled in this study. The rate of positive expression of SSTR2 in colorectal neuroendocrine neoplasms was 76.8%. Positive expression of SSTR2 in tumor tissues was associated with lymph node metastasis, muscularis invasion and distant metastasis (P < 0.05), but not with sex or age (P > 0.05). In addition, a significant correlation was found between SSTR2 expression and tumor diameter and histological grade (P < 0.05). CONCLUSION: Abnormal expression of SSTR2 correlates closely with some important clinicopathological characteristics of colorectal neuroendocrine neoplasms. SSTR2 may be used as a new biomarker for the diagnosis and prognosis evaluation of colorectal neuroendocrine neoplasms. © 2016 Baishideng Publishing Group Inc. All rights reserved. Source

Jia X.F.,The First Peoples Hospital of Jining City | Li J.,The First Peoples Hospital of Jining City | Zhao H.B.,The First Peoples Hospital of Jining City | Liu J.,Shandong Cancer Hospital | Liu J.J.,The First Peoples Hospital of Jining City
Genetics and Molecular Research | Year: 2015

The aim of this study was to explore epidermal growth factor receptor (EGFR) gene amplification and its relationship with cancer invasion and metastasis in non-small cell lung cancer (NSCLC). EGFR amplification in 45 patients with NSCLC and 15 subjects with normal lung tissues was detected by fluorescence in situ hybridization. The relationship between EGFR amplification and the clinicopathologic features of NSCLC was analyzed. EGFR gene amplifications were identified in 2 of 15 normal lung tissues (13.33%) and in 29 of 45 NSCLCs (64.44%). Patients <60 years had a 66.67% EGFR amplification rate, while patients ≥60 years had a rate of 62.50%. The EGFR amplification rates in male and female patients were 64.0% (16/25) and 65.0% (13/20), respectively. Pathologically, the EGFR amplification rate of patients with squamous cell carcinoma was 56.52% (13/23), and with adenocarcinoma was 72.72% (16/22). The EGFR amplification rate in NSCLCs with well-moderate differentiation was lower than in those with poor differentiation; 48.0% (12/25) vs 85.0% (17/20), respectively. Patients with lymph node metastasis had nearly double the amplification rate than those without metastasis; 90.0% (18/20) vs 44.0% (11/25), respectively. The rate of EGFR amplificationwas significantly higher in NSCLC than in normal lung tissue (64.44 vs 13.33%, P < 0.05), and was not correlated with age or gender (P > 0.05), but increased with clinical stage in NSCLCs (P < 0.05). Overall, these studies found that the rate of EGFR gene amplification was increased significantly in NSCLC and was closely related to lymphatic metastasis and TNM stage. © FUNPEC-RP. Source

Gao J.W.,The First Peoples Hospital of Jining City | Zhang K.F.,The First Peoples Hospital of Jining City | Lu J.S.,The First Peoples Hospital of Jining City | Su T.,The First Peoples Hospital of Jining City
Genetics and Molecular Research | Year: 2015

Cumulated evidence indicates that matrix metalloproteinase-3 (MMP-3) is significantly involved in cancer progression. Recent studies yielded conflicting results regarding the association between serum MMP-3 and ankylosing spondylitis (AS). To clarify this correlation, we performed a meta-analysis. Potential relevant studies were identified by searching the following databases: PubMed, Embase, CINAHL, Science Citation Index database, the Cochrane Library, Current Contents Index, Chinese Biomedical, the Chinese Journal Full-Text, and the Weipu Journal. Data from eligible studies were extracted and included into the meta-analysis using a random-effect model. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were used to assess the association between serum MMP-3 levels and AS. Thirteen case-control studies, including 707 AS cases and 442 healthy controls, were selected for the meta-analysis. The results indicate a significantly higher serum MMP-3 level in patients with AS than that in the controls (cases vs controls: SMD = 1.31, 95%CI = 0.84-1.78, P < 0.001). Ethnicity-subgroup analysis indicated a higher MMP-3 level in Asian and Caucasian patients with AS (all P < 0.05). This meta-analysis indicates that increased serum MMP-3 level correlates with the development of AS, suggesting that MMP-3 may present a clinical value in reflecting the progression of AS. Further larger sample size studies are warranted. © FUNPEC-RP. Source

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