The First Peoples Hospital of Guangzhou

of Guangzhou, China

The First Peoples Hospital of Guangzhou

of Guangzhou, China
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Yu J.,Sun Yat Sen University | Zhang C.-G.,The First Peoples Hospital of Fushan | Zhang S.-P.,Red Cross | Xiao W.-M.,The Peoples Hospital of Dongguan | And 7 more authors.
CNS Neuroscience and Therapeutics | Year: 2014

Introduction: Glucose variation is an important risk factor for the complications of diabetes mellitus. The plasma glucose level poststroke is in continuous fluctuation. However, whether the variation influences neurological improvement remains unknown. Aims: This observational study aimed to investigate the association of glucose variation with neurological improvement poststroke. Methods: We consecutively enrolled 216 ischemic stroke patients with no history of diabetes mellitus within 72 h of onset, with instant blood glucose <11.1 mmol/L at admission. The glucometabolic status was evaluated by an oral glucose tolerance test 1 day after admission and 14 days after stroke, respectively. The severity of neurological deficit was assessed with the National Institute of Health Stroke Scale (NIHSS). Results: Fourteen days after stroke, 31% patients were found to have impaired glucose tolerance and 30.6% were newly diagnosed diabetes mellitus by oral glucose tolerance test. A higher level of instant blood glucose at admission or fasting plasma glucose (FPG) at 1 day correlated with a less neurological improvement. The number of patients with no <20% decrease in NIHSS was significantly decreased in patient group with higher than 30% variation of either FPG or 2-h postprandial glucose. Similar correlation between glucose variation and neurological improvement was also found in 117 patients with 2-h postprandial glucose ≥7.8 mmol/L at 1 day. Conclusions: Inordinate glucose variation correlated with less neurological improvement poststroke, giving the evidence that the fluctuation of glucose levels in stroke patients should be taken into consideration during glucose modulation. © 2014 John Wiley & Sons Ltd.


Peng L.,Southern Medical University | Peng L.,The First Peoples Hospital of Foshan | Li P.,Southern Medical University | Li P.,The First Peoples Hospital of Guangzhou | And 7 more authors.
PLoS ONE | Year: 2013

Objective:To explore the association between transforming growth factor-beta1 (TGF-β1) T869C polymorphism and risk of ischemic stroke (IS) by performing a meta-analysis based on published articles.Methods:Systematic electronic searches of PubMed, Science Direct, BIOSIS Previews, Chinese Biomedical Database, Chinese National Knowledge Infrastructure, and WANFANG Database were performed. The strength of the association was calculated by pooled odds ratios (ORs) with 95% confidence intervals (95%CIs). Subgroup analysis was conducted to explore potential sources of heterogeneity. Sensitivity analysis was performed to elucidate the stability of the outcomes. Publication bias was evaluated by Begg's funnel plot and Egger's test.Results:A total of 6 studies involving 1701 cases were included. The overall estimates did not show any significant association between TGF-β1 T869C polymorphism and risk of IS under all genetic models (C vs. T: OR = 1.08,95%CI = 0.88-1.32; CC vs. TT:OR = 1.17,95%CI = 0.79-1.72; CT vs. TT: OR = 0.91, 95%CI = 0.68-1.22; CC+CT vs. TT: OR = 0.99, 95%CI = 0.73-1.35; CC vs. CT+TT: OR = 1.23, 95%CI = 0.95-1.59). Similar lacking associations were observed in subgroup analysis based on ethnicity and source of controls. When stratified by study design, significant increased association of IS risk was found in cohort studies under genetic models except recessive model(C vs. T: OR = 1.18, 95%CI = 1.05-1.32; CC vs. TT: OR = 1.40, 95%CI = 1.10-1.77; CT vs. TT: OR = 1.23, 95%CI = 1.02-1.49; CC+CT vs. TT: OR = 1.27, 95%CI = 1.03-1.57; CC vs. CT+TT, OR = 1.21, 95%CI = 0.99-1.47), whereas in case-control studies a significant decreased risk was detected under heterozygote comparison(CT vs. CC: OR = 0.72, 95%CI = 0.57-0.92). However, after correction for multiple testing, the associations were observed to be null significant in both cohort and case-control subgroups among all genetic models.Conclusion:This meta-analysis suggested that current epidemiological studies of TGF-β1 T869C polymorphism are too inconsistent to draw a conclusion on the association with IS susceptibility. Given the small sample size and remarkable between-study heterogeneity, further well-designed prospective large-scale studies are warranted. © 2013 Peng et al.


Tang L.,Guangzhou Population and Family Planning Research Institute | Wang W.,The First Peoples Hospital of Guangzhou | Liang G.,The First Peoples Hospital of Guangzhou | Wu W.,Guangzhou Population and Family Planning Research Institute | And 3 more authors.
Chinese Journal of Andrology | Year: 2013

Objective To optimize the entrance angle and channel width of a microfluidic sperm sorter. Methods Thirty semen specimens were processed using polydimethylsiloxane (PDMS)chip based sperm sorters of different entrance angles (30°, 45°, 60°)and channel widths (120 μm, 180 μm, 250 μm), and the sorted sperms were compared with those in raw samples in terms of motility, normal morphology ratio and hypoosmotic swelling rate. A microchip with the optimized configuration was used to process semen specimens from 40 male infertility patients, and the results were compared with those from the conventional swiming-up method. Routine sperm parameters were analyzed using the computer assisted sperm analysis (CASA), and sperm DNA integrity was determined using the sperm chromatin dispersion test (SCD). Results Microfluidic sperm sorters with different entrance angles and channel widths were all able to improve sperm activity and normal morphology ratio significantly in all the 40 semen samples (P<0.01). Microsorters with different entrance angles and widths didn 't show significant difference in either sperm activity or normal morphology ratio. With regards to recovery efficiency, a microchannel with entrance angle of 30° and channel width of 250 μm was superior to the other configurations (P<0.01). The microfluidic method showed advantage over the swimming-up method in terms of routine sperm parameters and sperm DNA integrity. Conclusion The highest sperm sorting efficiency was obtained using a microfludic sperm sorter with entrance angle of 30° and width of 250 μm. Compared with the conventional sperm sorting method, the presented microfluidic approach showed advantages of high sorting efficiency, less DNA damage and simple operation. Therefore, this technology holds the potential to be used in sorting motile spermatozoa for insemination and in vitro fertilization.


Li L.,Chongqing Medical University | Zhao Y.,Chongqing Medical University | Liu J.-H.,The First Peoples Hospital of Guangzhou | Wu S.-Z.,Chongqing Medical University | And 3 more authors.
Chinese Journal of Medical Imaging Technology | Year: 2010

Objective: To investigate development effect of draining lymph nodes of VX2 tumor with contrast-enhanced ultrasonography using injection of submicron lipid microbubbles (SLMs). Methods: VX2 breast cancer models of 10 rabbits were constructed and 1 ml SLMs were administered subcutaneously around tumor in each rabbit. After the injection-sites were massaged, contrast-enhanced ultrasonography (CEUS), color Doppler flow imaging (CDFI) and a second CEUS were performed. The suspicious lymph nodes with nodular contrast enhancement were labeled and surgically removed for histologic examination. Results: After subcutaneous administration of SLMs and regional massage, CEUS could detect contrast enhanced nodular structures in the axillary region. CDFI showed blooming effect and transient mosaic color. The nodular structure indicating lymph nodes could be refilled and enhanced again during second massage in 2-5 min of the same injection-sites. Histological examination found the CEUS regions as lymph nodes with or without minute tumor metastasis, while the lymph nodes with large defective enhancement area usually located under the condition of wide metastasis or necrosis. Conclusion: Subcutaneous injection of SLMs combined with CEUS can image and detect the draining lymph nodes of VX2 tumor with the contrast, color blooming and contrast method.


To investigate the effect of treatment of osteoporotic proximal humeral fractures in elderly patients with a proximal humeral internal locking system (PHILOS) and minimally invasive injectable graft (MIIG). Patients who conformed to the inclusion criteria were randomly divided into two groups: group A (21 cases) were treated with PHILOS alone and group B (29 cases) were treated with PHILOS augmentation plus minimally invasive injectable graft (MIIG) X3 Hivisc. Postoperative follow-up was performed regularly to check for complications, reduction loss and fracture healing by imaging. Shoulder joint function was scored and clinical results evaluated according to the Neer scoring system. All patients were followed-up and achieved fracture healing. The complication rate in group A (six cases) was greater than in group B (one case), the differences being statistically significant. The reduction loss in group A (2.9 ± 0.4 mm) was greater than in group B (1.5 ± 0.3 mm), this difference also being statistically significant. According to the Neer system, the excellent and good rate was 76.2% in group A and 82.8% in group B. PHILOS using MIPPO and augmented with MIIG X3 Hivisc produces satisfactory clinical results in aged patients with osteoporotic proximal humeral fractures and the method has advantages such as relatively minor trauma, stable fixation, fewer complications, and better joint function. © 2011 Tianjin Hospital and Blackwell Publishing Asia Pty Ltd.


Zeng G.-J.,The First Peoples Hospital of Guangzhou | Liu J.-H.,The First Peoples Hospital of Guangzhou | Ou W.-C.,The First Peoples Hospital of Guangzhou | Xu S.-F.,The First Peoples Hospital of Guangzhou
Chinese Journal of Medical Imaging Technology | Year: 2013

Objective: To explore the value of ultrasonography on the differential diagnosis of solid type granulomatous mastitis and breast cancer. Methods: Two-dimensional ultrasonic and CDFI manifestations of 12 patients with granulomatous mastitis and 328 patients with breast cancer confirmed by pathology were retrospectively analyzed and compared. Results: There were 7 cases of solid type granulomatous mastitis, which presented as heterogeneous masses with low echoes in the internal. There were strong glandular echoes in the low echoes, presenting as pseudokidney sign. Breast cancers mainly manifested as irregular shapes, heterogeneous echoes with or without grit calcification and blurred boundaries. The tumors' longitudinal diameters were longer than transverse diameters, and irregular malignant halos were observed around the tumors. CDFI showed rich blood supply for solid type granulomatous mastitis, and the vessels distributed at the border of mass or locally. Meanwhile, perforating vessels, branches of perforating vessels, branches of direct vessels and central large vessels were characteristic vascular distribution patterns of breast cancer. The blood flow resistance indexes were high in both diseases. Conclusion: There are some differences between solid type granulomatous mastitis and breast cancer in two-dimensional ultrasound and CDFI. Ultrasound has some value on the differential diagnosis of these two diseases. Copyright © 2013 by the Press of Chinese Journal of Medical Imaging Technology.


Huang Y.-f.,The First Peoples Hospital of Guangzhou | Wei Y.-m.,The First Peoples Hospital of Guangzhou | Li Q.-x.,The First Peoples Hospital of Guangzhou | Nie Y.-q.,The First Peoples Hospital of Guangzhou | Gu W.-l.,The First Peoples Hospital of Guangzhou
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2011

BACKGROUND: It has been reported recently that a higher CD133 positive expression in the peripheral blood of cancer patients was detected. OBJECTIVE: To investigate the expression and clinical value of CD133 mRNA in the peripheral blood of patients with colorectal cancer. METHODS: The flow cytometry method and RT-PCR were used to detect the expression of CD133 mRNA and protein in peripheral blood samples which were from 20 controls and 29 patients with colorectal cancer. RESULTS AND CONCLUSION: The CD133+ cell percentages in both peripheral blood samples of controls and colorectal cancer patients without metastasis were lower than those of colorectal cancer patients with metastasis (P < 0.01). RT-PCR results revealed 5 cases of positive CD133 mRNA expression in all 14 colorectal cancer patients with metastasis, and the positive ratio was 35.7%, in which run more than 38 PCR circles. The expression of CD133 in peripheral blood cells of colorectal cancer patients with metastasis is higher than that of normal controls and colorectal cancer patients without metastasis.


PubMed | The First Peoples Hospital of Guangzhou
Type: Comparative Study | Journal: Orthopaedic surgery | Year: 2011

To investigate the effect of treatment of osteoporotic proximal humeral fractures in elderly patients with a proximal humeral internal locking system (PHILOS) and minimally invasive injectable graft (MIIG).Patients who conformed to the inclusion criteria were randomly divided into two groups: group A (21 cases) were treated with PHILOS alone and group B (29 cases) were treated with PHILOS augmentation plus minimally invasive injectable graft (MIIG) X3 Hivisc. Postoperative follow-up was performed regularly to check for complications, reduction loss and fracture healing by imaging. Shoulder joint function was scored and clinical results evaluated according to the Neer scoring system.All patients were followed-up and achieved fracture healing. The complication rate in group A (six cases) was greater than in group B (one case), the differences being statistically significant. The reduction loss in group A (2.9 0.4 mm) was greater than in group B (1.5 0.3 mm), this difference also being statistically significant. According to the Neer system, the excellent and good rate was 76.2% in group A and 82.8% in group B.PHILOS using MIPPO and augmented with MIIG X3 Hivisc produces satisfactory clinical results in aged patients with osteoporotic proximal humeral fractures and the method has advantages such as relatively minor trauma, stable fixation, fewer complications, and better joint function.

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