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Peng J.C.,Anhui Medical University | Jiang Q.,The First Peoples Hospital of Anqing | Cheng Z.P.,Anhui Medical University | Luo Z.G.,Anhui Medical University | And 3 more authors.
Biomedical Research (India)

An increased level of serum cardiac troponin I is a specific biomarker for myocardial injury. The objective of this study was to evaluate the changes in cardiac troponin I levels to determine myocardial injury following diagnostic cardiac catheterization. A prospective cohort study was carried out between July 1 2006 and March 31 2012 among patients who underwent diagnostic cardiac catheterization in a tertiary hospital. Blood samples were collected at baseline and at 6- and 12- hours of the procedure to measure any changes in cardiac troponin I levels. A total of 264 adult patients; consisting of 157 males and 107 females, who underwent diagnostic cardiac catheterization were chosen for the study. Out of them 42 (16%) had a positive family history of coronary artery disease (CAD). Before the procedure, the mean cardiac troponin I level was 0.059 ± 0.030 ng/mL. However, the mean cardiac troponin I level after 6 hours of catheterization was 0.062 ± 0.041 ng/mL (P = 0.189) and was 0.063 ± 0.026 ng/mL (P = 0.099) after 12 hours. Average cardiac troponin I levels at 6- and 12- hours following diagnostic cardiac catheterization did not differ according to patients’ demographic or clinical characteristics (P >0.05). No in-cathlab complications and major adverse cardiac events were observed after onemonth. There were no significant changes in cardiac troponin I levels before or at 6- and 12- hours after diagnostic cardiac catheterization. This study, therefore, suggests that diagnostic cardiac catheterization does not appear to be associated with substantial subclinical myocardial injury. © 2015, Scientific Publishers of India. All rights reserved. Source

Liu T.,The First Peoples Hospital of Anqing | Fang X.-C.,The First Peoples Hospital of Anqing | Ding Z.,Anqing Municipal Hospital | Sun Z.-G.,Fuzhou General Hospital of Nanjing Military Command | And 2 more authors.
FEBS Open Bio

Inflammatory markers have been proposed to predict clinical outcomes in many types of cancers. The purpose of this study was to explore the influence of the lymphocyte-to-monocyte ratio (LMR) on clinical prognosis of patients with osteosarcoma. This study collected 327 patients who underwent surgical treatment for osteosarcoma during the period 2006-2010. LMR was calculated from pre-operative peripheral blood cells counts. The optimal cut-off value of LMR was determined based on receiver operating characteristic curve analysis. Overall survival (OS) and event free survival (EFS) was plotted using the Kaplan-Meier method and evaluated by the log-rank test. A predictive model was established to predict clinical prognosis for OS, and the predictive accuracy of this model was determined by concordance index (c-index). Our results showed that young age, elevated alkaline phosphatase, metastasis at diagnosis, chemotherapy, lymphocyte and monocyte counts were significantly associated with LMR. Low LMR was associated with shorter OS and EFS (P< 0.001), and was an independent predictor of both OS and EFS (HR = 1.72, 95% CI = 1.14-2.60, P= 0.010; HR = 1.89, 95% CI = 1.32-2.57, P= 0.009). The nomogram performed well in the prediction of overall survival in patients with osteosarcoma (c-index 0.630). In conclusion, low pre-operative LMR is associated with a poor prognosis in patients suffering from osteosarcoma. A prospective study is warranted for further validation of our results. © 2015 The Authors. Source

Zhu F.-L.,The First Peoples Hospital of Anqing | Ling A.-S.,The First Peoples Hospital of Anqing | Wei Q.,Zhejiang Provincial Peoples Hospital | Ma J.,Zhejiang Provincial Peoples Hospital | Lu G.,Zhejiang Provincial Peoples Hospital
Asian Pacific Journal of Cancer Prevention

Objective: To evaluate the values of 4 tumor markers in serum and ascites and their ascites/serum ratios in the identification and diagnosis of benign and malignant ascites. Materials and Methods: A total of 76 patients were selected as subjects and divided into malignant ascites group (45 cases) and benign ascites group (31 cases). Samples of ascites and serum of all hospitalized patients were collected before treatment. The levels of carcinoembryonic antigen (CEA), alpha fetoprotein (AFP), cancer antigen 125 (CA125) and carbohydrate antigen 19-9 (CA19-9) were detected by chemiluminescence (CLIA) . Results: CEA, AFP and CA19-9 in both serum and ascites as well as CA125 in ascites were evidently higher in the malignant ascites group than in the benign ascites group (P<0.01). Malignant ascites was associated with elevated ascites/serum ratios for AFP and CA125 (P<0.01). The areas under receiver operating characteristic (AUROCs) of CEA and CA125 in ascites and the ratios of ascites/serum of AFP, CEA, CA125 and CA19-9 were all >0.7, suggesting certain values, while those of ascites CA19-9 and serum CEA were 0.697 and 0.629 respectively, indicating low accuracy in the identification and diagnosis of benign and malignant ascites. However, the AUROCs of the remaining indexes were <0.5, with no value for identification and diagnosis. Compared with single index, the sensitivity of combined detection increased significantly (P<0.05), in which the combined detection of CEA, CA19-9 and CA125 in ascites as well as the ratio of ascites/serum of CEA, CA19-9, CA125 and AFP had the highest sensitivity (98.4%) but with relevantly low specificity. Both sensitivity and specificity of combined detection should be comprehensively considered so as to choose the most appropriate index. Conclusions: Compared with single index, combined detection of tumor markers in serum and ascites can significantly improve the diagnostic sensitivity and specificity. Source

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