The First Peoples Hospital of Anqing

Anqing, China

The First Peoples Hospital of Anqing

Anqing, China
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Liu T.,The First Peoples Hospital of Anqing | Fang X.-C.,The First Peoples Hospital of Anqing | Ding Z.,Anqing Municipal Hospital | Sun Z.-G.,Fuzhou General Hospital of Nanjing Military Command | And 2 more authors.
FEBS Open Bio | Year: 2015

Inflammatory markers have been proposed to predict clinical outcomes in many types of cancers. The purpose of this study was to explore the influence of the lymphocyte-to-monocyte ratio (LMR) on clinical prognosis of patients with osteosarcoma. This study collected 327 patients who underwent surgical treatment for osteosarcoma during the period 2006-2010. LMR was calculated from pre-operative peripheral blood cells counts. The optimal cut-off value of LMR was determined based on receiver operating characteristic curve analysis. Overall survival (OS) and event free survival (EFS) was plotted using the Kaplan-Meier method and evaluated by the log-rank test. A predictive model was established to predict clinical prognosis for OS, and the predictive accuracy of this model was determined by concordance index (c-index). Our results showed that young age, elevated alkaline phosphatase, metastasis at diagnosis, chemotherapy, lymphocyte and monocyte counts were significantly associated with LMR. Low LMR was associated with shorter OS and EFS (P< 0.001), and was an independent predictor of both OS and EFS (HR = 1.72, 95% CI = 1.14-2.60, P= 0.010; HR = 1.89, 95% CI = 1.32-2.57, P= 0.009). The nomogram performed well in the prediction of overall survival in patients with osteosarcoma (c-index 0.630). In conclusion, low pre-operative LMR is associated with a poor prognosis in patients suffering from osteosarcoma. A prospective study is warranted for further validation of our results. © 2015 The Authors.


PubMed | The First Peoples Hospital of Anqing, Anqing Municipal Hospital, Fuzhou General Hospital of Nanjing Military Command and The Second Peoples Hospital of Lianyungang
Type: | Journal: FEBS open bio | Year: 2015

Inflammatory markers have been proposed to predict clinical outcomes in many types of cancers. The purpose of this study was to explore the influence of the lymphocyte-to-monocyte ratio (LMR) on clinical prognosis of patients with osteosarcoma. This study collected 327 patients who underwent surgical treatment for osteosarcoma during the period 2006-2010. LMR was calculated from pre-operative peripheral blood cells counts. The optimal cut-off value of LMR was determined based on receiver operating characteristic curve analysis. Overall survival (OS) and event free survival (EFS) was plotted using the Kaplan-Meier method and evaluated by the log-rank test. A predictive model was established to predict clinical prognosis for OS, and the predictive accuracy of this model was determined by concordance index (c-index). Our results showed that young age, elevated alkaline phosphatase, metastasis at diagnosis, chemotherapy, lymphocyte and monocyte counts were significantly associated with LMR. Low LMR was associated with shorter OS and EFS (P<0.001), and was an independent predictor of both OS and EFS (HR=1.72, 95% CI=1.14-2.60, P=0.010; HR=1.89, 95% CI=1.32-2.57, P=0.009). The nomogram performed well in the prediction of overall survival in patients with osteosarcoma (c-index 0.630). In conclusion, low pre-operative LMR is associated with a poor prognosis in patients suffering from osteosarcoma. A prospective study is warranted for further validation of our results.


Zhu F.-L.,The First Peoples Hospital of Anqing | Ling A.-S.,The First Peoples Hospital of Anqing | Wei Q.,Zhejiang Provincial Peoples Hospital | Ma J.,Zhejiang Provincial Peoples Hospital | Lu G.,Zhejiang Provincial Peoples Hospital
Asian Pacific Journal of Cancer Prevention | Year: 2015

Objective: To evaluate the values of 4 tumor markers in serum and ascites and their ascites/serum ratios in the identification and diagnosis of benign and malignant ascites. Materials and Methods: A total of 76 patients were selected as subjects and divided into malignant ascites group (45 cases) and benign ascites group (31 cases). Samples of ascites and serum of all hospitalized patients were collected before treatment. The levels of carcinoembryonic antigen (CEA), alpha fetoprotein (AFP), cancer antigen 125 (CA125) and carbohydrate antigen 19-9 (CA19-9) were detected by chemiluminescence (CLIA) . Results: CEA, AFP and CA19-9 in both serum and ascites as well as CA125 in ascites were evidently higher in the malignant ascites group than in the benign ascites group (P<0.01). Malignant ascites was associated with elevated ascites/serum ratios for AFP and CA125 (P<0.01). The areas under receiver operating characteristic (AUROCs) of CEA and CA125 in ascites and the ratios of ascites/serum of AFP, CEA, CA125 and CA19-9 were all >0.7, suggesting certain values, while those of ascites CA19-9 and serum CEA were 0.697 and 0.629 respectively, indicating low accuracy in the identification and diagnosis of benign and malignant ascites. However, the AUROCs of the remaining indexes were <0.5, with no value for identification and diagnosis. Compared with single index, the sensitivity of combined detection increased significantly (P<0.05), in which the combined detection of CEA, CA19-9 and CA125 in ascites as well as the ratio of ascites/serum of CEA, CA19-9, CA125 and AFP had the highest sensitivity (98.4%) but with relevantly low specificity. Both sensitivity and specificity of combined detection should be comprehensively considered so as to choose the most appropriate index. Conclusions: Compared with single index, combined detection of tumor markers in serum and ascites can significantly improve the diagnostic sensitivity and specificity.


Yu J.-W.,Anhui University | Yu J.-W.,The First Peoples Hospital Of Anqing | Hao J.-Q.,Anhui University | Hu Z.-G.,The Provincial Hospital of Anhui | Qian L.-T.,The Provincial Hospital of Anhui
Academic Journal of Second Military Medical University | Year: 2016

Objective To compare the thcrapcutic effects and adverse reaction of concurrent chemoradiotherapy with pure chemotherapy for local progressive gastric cancer following D2 lymph node dissection. Methods Seventy-nine patients with progressive gastric cancer who underwent RO gastric resection and D2 lymph node dissection were randomly divided into two groups. After radical gastrectomy, the experimental group (n = 40) received radiotherapy concurrent with capecitabine chemotherapy, and then followed by 4 cycles of XELOX chemotherapy; however, the control group (n = 39) only received 6 cyclcs of XELOX chemotherapy. The local recurrence rates, 3-year disease-free survival rates, 3-year ovcrall survival rates and adverse reactions were evaluated after the treatment. Resulte The local recurrence rate in the experimental group was significantly lower than that of the control group (40. 0%[16/40] vs 64. 1% [25/39],P=0. 032). The 3-year disease-free survival rates and 3-year overall survival rates of the experimental group were higher than those in the control group, but with no significant difference (P> 0. 05). The 3 year overall survival rate of patients with positive lymph node was significantly higher in the experimental group than in the control group (45. 2% [14/31] vs 18. 5% [5/27], P=0. 049), with their median disease-free survival (mDFS)periods being 26 months and 19 months, respectively (P = 0. 024). The incidences of hematological and gastrointestinal toxicities in the experimental group were higher than those in the control group. Concllision Concurrent chemoradiotherapy and chemotherapy can greatly reducc local recurrence after curative resection and D2 lymph node dissection in gastric cancer patients. In patients with lymph node positive gastric cancer, postoperative concurrent chemoradiotherapy may improve their survival. The main adverse reactions of the concurrent treatment are hematological and gastrointestinal toxicities. © 2016, Second Military Medical University Press. All right reserved.


Peng J.C.,Anhui Medical University | Peng J.C.,The First Peoples Hospital Of Anqing | Jiang Q.,The First Peoples Hospital Of Anqing | Cheng Z.P.,Anhui Medical University | And 4 more authors.
Biomedical Research (India) | Year: 2015

An increased level of serum cardiac troponin I is a specific biomarker for myocardial injury. The objective of this study was to evaluate the changes in cardiac troponin I levels to determine myocardial injury following diagnostic cardiac catheterization. A prospective cohort study was carried out between July 1 2006 and March 31 2012 among patients who underwent diagnostic cardiac catheterization in a tertiary hospital. Blood samples were collected at baseline and at 6- and 12- hours of the procedure to measure any changes in cardiac troponin I levels. A total of 264 adult patients; consisting of 157 males and 107 females, who underwent diagnostic cardiac catheterization were chosen for the study. Out of them 42 (16%) had a positive family history of coronary artery disease (CAD). Before the procedure, the mean cardiac troponin I level was 0.059 ± 0.030 ng/mL. However, the mean cardiac troponin I level after 6 hours of catheterization was 0.062 ± 0.041 ng/mL (P = 0.189) and was 0.063 ± 0.026 ng/mL (P = 0.099) after 12 hours. Average cardiac troponin I levels at 6- and 12- hours following diagnostic cardiac catheterization did not differ according to patients’ demographic or clinical characteristics (P >0.05). No in-cathlab complications and major adverse cardiac events were observed after onemonth. There were no significant changes in cardiac troponin I levels before or at 6- and 12- hours after diagnostic cardiac catheterization. This study, therefore, suggests that diagnostic cardiac catheterization does not appear to be associated with substantial subclinical myocardial injury. © 2015, Scientific Publishers of India. All rights reserved.


Ling A.,The First Peoples Hospital of Anqing | Zhu F.,The First Peoples Hospital of Anqing | Wu P.,The First Peoples Hospital of Anqing | Fang C.,The First Peoples Hospital of Anqing | Cao F.,The First Peoples Hospital of Anqing
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences | Year: 2016

Abstract available from the publisher.OBJECTIVE: To evaluate the safety and prognosis for patients with early esophageal cancer and precancerous lesions after endoscopic submucosal dissection (ESD).
METHODS: A total of 89 patients were admitted to the Department of internal medicine in the First People's Hospital of Anqing from August 2008 to August 2011. All patients were treated with ESD at the early stage of esophageal cancer and precancerous lesions. The patients' laboratory data and relevant medical history were collected. The postoperative complications and long-term effects of ESD were analyzed.
RESULTS: Eighty-nine patients were followed up with 100% response rate. Among 89 cases, 16 were early esophageal cancer, 38 were high-grade esophageal neoplasia and 35 were low-grade esophageal neoplasia. The one-time whole piece resection rate, complete resection rate and curative resection rate was 93.3% (84/89), 92.1% (82/89) and 92.1% (82/89), respectively. Two cases suffered intraoperative perforation with a rate of 2.2% and these 2 patients performed the intraoperative endoscopic repair; one case suffered the postoperative delayed bleeding with a rate of 1.1% and the patient underwent the conservative treatment; three cases suffered the esophageal stenosis with a rate of 3.4%. All patients were followed-up for 10-58 (36.3±21.2) months. In this period, one case recurred after ESD for 3 years with a rate of 1.1%; two cases were dead. The three-year survival rate was 97.8%.
CONCLUSION: The early esophageal cancer and precancerous lesions can be treated with ESD. The method is safe and the prognosis is good.


PubMed | The First Peoples Hospital of Anqing
Type: Journal Article | Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences | Year: 2016

To evaluate the safety and prognosis for patients with early esophageal cancer and precancerous lesions after endoscopic submucosal dissection (ESD).A total of 89 patients were admitted to the Department of internal medicine in the First Peoples Hospital of Anqing from August 2008 to August 2011. All patients were treated with ESD at the early stage of esophageal cancer and precancerous lesions. The patients laboratory data and relevant medical history were collected. The postoperative complications and long-term effects of ESD were analyzed.Eighty-nine patients were followed up with 100% response rate. Among 89 cases, 16 were early esophageal cancer, 38 were high-grade esophageal neoplasia and 35 were low-grade esophageal neoplasia. The one-time whole piece resection rate, complete resection rate and curative resection rate was 93.3% (84/89), 92.1% (82/89) and 92.1% (82/89), respectively. Two cases suffered intraoperative perforation with a rate of 2.2% and these 2 patients performed the intraoperative endoscopic repair; one case suffered the postoperative delayed bleeding with a rate of 1.1% and the patient underwent the conservative treatment; three cases suffered the esophageal stenosis with a rate of 3.4%. All patients were followed-up for 10-58 (36.321.2) months. In this period, one case recurred after ESD for 3 years with a rate of 1.1%; two cases were dead. The three-year survival rate was 97.8%.The early esophageal cancer and precancerous lesions can be treated with ESD. The method is safe and the prognosis is good.


PubMed | The First Peoples Hospital of Anqing
Type: Journal Article | Journal: Asian Pacific journal of cancer prevention : APJCP | Year: 2015

To evaluate the values of 4 tumor markers in serum and ascites and their ascites/serum ratios in the identification and diagnosis of benign and malignant ascites.A total of 76 patients were selected as subjects and divided into malignant ascites group (45 cases) and benign ascites group (31 cases). Samples of ascites and serum of all hospitalized patients were collected before treatment. The levels of carcinoembryonic antigen (CEA), alpha fetoprotein (AFP), cancer antigen 125 (CA125) and carbohydrate antigen 19-9 (CA19-9) were detected by chemiluminescence (CLIA) .CEA, AFP and CA19-9 in both serum and ascites as well as CA125 in ascites were evidently higher in the malignant ascites group than in the benign ascites group (P<0.01). Malignant ascites was associated with elevated ascites/serum ratios for AFP and CA125 (P<0.01). The areas under receiver operating characteristic (AUROCs) of CEA and CA125 in ascites and the ratios of ascites/serum of AFP, CEA, CA125 and CA19-9 were all >0.7, suggesting certain values, while those of ascites CA19-9 and serum CEA were 0.697 and 0.629 respectively, indicating low accuracy in the identification and diagnosis of benign and malignant ascites. However, the AUROCs of the remaining indexes were <0.5, with no value for identification and diagnosis. Compared with single index, the sensitivity of combined detection increased significantly (P<0.05), in which the combined detection of CEA, CA19-9 and CA125 in ascites as well as the ratio of ascites/serum of CEA, CA19-9, CA125 and AFP had the highest sensitivity (98.4%) but with relevantly low specificity. Both sensitivity and specificity of combined detection should be comprehensively considered so as to choose the most appropriate index.Compared with single index, combined detection of tumor markers in serum and ascites can significantly improve the diagnostic sensitivity and specificity.

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