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Liu K.,Changzheng Hospital | Wang G.,The Eighty fifth Hospital | Ding H.,The first Peoples Hospital | Chen Y.,Changhai Hospital | And 2 more authors.
BMC Cancer | Year: 2010

Background: The putative tumor metastasis suppressor 1(MTSS1) is an actin-binding scaffold protein that has been implicated to play an important role in carcinogenesis and cancer metastasis, yet its role in the development of gastric cancer has not been well illustrated. In this study, we detected MTSS1 expression and explored its clinical significance in gastric cancer.Methods: Immunohistochemistry was performed using tissue microarrays containing gastric adenocarcinoma specimens from 1,072 Chinese patients with normal adjacent mucosa, primary gastric cancer and lymph node (LN) metastasis and specific antibody against MTSS1. MTSS1 mRNA and protein expression were detected by reverse transcription-polymerase chain reaction and Western blotting. The clinical follow-up was done in the 669 patients living in Shanghai that was chose from the 1072 cases.Results: Complete loss of MTSS1 expression was observed in 751 cases (70.1%) of the 1,072 primary tumors and 103 (88%) of 117 nodal metastases; and loss of MTSS1 expression was significantly associated with poorly differentiated tumors, large tumor size, deep invasion level, the presence of nodal metastases and advanced disease stage. Moreover, multivariate analysis demonstrated that loss of MTSS1 expression correlated significantly with poor survival rates (RR = 0.194, 95% CI = 0.144-0.261, P < 0.001).Conclusions: MTSS1 expression decreased significantly as gastric cancer progressed and metastasized, suggesting MTSS1 may serve as a useful biomarker for the prediction of outcome of gastric cancer. © 2010 Liu et al; licensee BioMed Central Ltd.

Wu S.-J.,The First Peoples Hospital | Zeng Z.-C.,The First Peoples Hospital
International Journal of Ophthalmology | Year: 2010

AIM: To evaluate the surgical results and indicators of health economics (including length of stay, hospital costs) in patients with small incision phacoemulsification cataract surgery by clinical pathway, and to develop the system management and methods of cataract surgery project for primary hospital. METHODS: The clinical pathway table of senile cataract were developed and implemented, after that, 96 patients with senile cataract were randomly divided into two groups: without small incision phacoemulsification cataract surgery (group A) and with phacoemulsification than surgery (group B), and the vision, complications, hospitalization days and total cost in the postoperative day 1 of the both groups were observed. RESULTS: Both groups were significantly improved in visual acuity in the postoperative day 1 (P < 0.01), but there were no significant differences (P > 0.05) compared both groups; group A had the lower incidence of corneal edema than B group, the difference was statistically significant (P < 0.05), but there were no significant difference in the incidence of complications and hospitalization days (P > 0.05); but, the average cost of hospitalization of the A group was lower than that of B group (P < 0.01). CONCLUSION: The small incision phacoemulsification cataract surgery by the clinical pathway have the better visual acuity, fewer complications, shorter hospitalization days, fewer financial burden, and in line with the fundamental purpose of health economics, which is worth promoting in the primary hospital.

Zhou R.-Z.,The First Peoples Hospital
International Eye Science | Year: 2013

AIM: To explore the effect of glaucoma drugs joint surgical treatment on patients with tear of MUC5AC and ocular surface. METHODS: Totally 26 cases (29 eyes) underwent glaucoma and cataract surgery who with history of glaucoma drugs admitted to our hospital in March 2010 to September 2011 were included. The content of tear MUC5AC and the ocular surface function scores of patients and healthy people at different time point were measured and analyzed. The relativity between types and taking time of medication, and ocular surface function scores before and after surgery was analyzed. The change of ocular surface function score, and the content of tear MUC5AC before and after surgery was compared. RESULTS: Content of tear MUC5AC of glaucoma patients at each period was significantly lower than that of healthy people. There was statistically significance at preoperative 1 day, postoperative 1 month, 3 months (P=0.0168, P=0.0001, P=0.0150), and there was no statistically significance postoperative 6 months (P=0.2230). The content of tear MUC5AC of glaucoma patients decreased significantly post-operation, then gradually increased. Comparing the content of tear MUC5AC 1 month post-operation with 1 day pre-operation, 3 months and 6 months post-operation, there was statistically significance (P=0.0365, P=0.0329, P=0.0004). There was a positive correlation between preoperative ocular surface function score and the taking time and types of medication (P=0.0427, P=0.0327), and there was no correlation 6 months post-operation (P=0.1788, P=0.9916). The ocular surface function score of glaucoma patients was significantly higher, then gradually reduced, there was statistically significance between 1 month post-operation and 1 day pre-operation, 3 months and 6 months post-operation (P=0.0012, P=0.0001, P=0.0000). Ocular surface function score was significantly lower 6 months post-operation, compared with the preoperative 1 day, there was statistically significance (P=0.0049). CONCLUSION: Glaucoma medications combined with glaucoma and cataract surgery impaired tear MUC5AC and ocular surface, such kind of damage is more obvious with the increase of taking time and types of the drug and gradually improves with the post-operative time extending. Copyright 2013 by the IJO Press.

Zeng Y.,the First Peoples Hospital
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2011

To compare the therapeutic effect between endoscopic thyroidectomy and open thyroidectomy. One hundred and nine patients were randomly divided into two groups. The first group with 52 patients were carried out endoscopic thyroidectomy; and the second group with 57 patients was carried out open thyroidectomy. Clinical features including operation time, operative blood loss, hospitalization and complications were compared between the two groups. The average operative time was (105.1 +/- 30.2) min in endoscopic group and (145.3 +/- 27.4) min in open group (P<0.01); the mean operative blood loss was (7.5 +/- 4.2) ml in endoscopic group and (48.6 +/- 18.6) ml in open group (P<0.01); the average hospitalization after operation was (4.1 +/- 1.4) days and (8.0 +/- 1.9) days (P<0.01), the complication rate was 5.8% in endoscopic group and 8.8% in open group (P<0.01). Compared to the traditional open surgery, endoscopic thyroidectomy is safe and effective,with advantages in terms of the aesthetic property,the amount of bleeding and the postoperative complications.

Fan C.X.,The First Peoples Hospital
Zhonghua zhong liu za zhi [Chinese journal of oncology] | Year: 2010

To explore the enhancing effect of compound Kusheg injection in chemotherapy for patients with stage III and IV non-small cell lung cancer (NSCLC). A total of 286 patients with advanced NSCLC were enrolled in this study. The patients were treated with either compound Kusheng injection in combination with NP (NVB + CBP) chemotherapy (vinorelbine and carboplatin, n = 144), or with NP (NVB + CBP) chemotherapy alone (n = 142). The chemotherapy was performed for 4 cycles of 3 weeks, and the therapeutic efficacy was evaluated every 2 weeks. The following indicators were observed: levels of Hb, WBC, PLT and T cell subpopulations in blood, serum IgG level, short-term efficacy, adverse effects and quality of life. The gastrointestinal reactions and the myelosuppression in the combination chemotherapy group were alleviated as compared with the chemotherapy alone group, showing a significant difference (P < 0.05). CD(8)(+) cells were markedly declined in the combination chemotherapy group, and the CD(4)(+)/CD(8)(+) ratio showed an elevation trend in the chemotherapy alone group. The KPS scores and serum IgM and IgG levels were higher in the combination chemotherapy group than those in the chemotherapy alone group (P < 0.01 and P < 0.05). The serum lgA levels were not significantly different in the two groups. The compound Kusheng injection plus NP chemotherapy regimen shows better therapeutic effect, reduces adverse effects of chemotherapy and improves the quality of life in patients with stage III and IV NSCLC.

Sa M.,Central South University | Ying L.,Central South University | Tang A.-G.,Central South University | Xiao L.-D.,The First Peoples Hospital | Ren Y.-P.,Central South University
Clinica Chimica Acta | Year: 2012

Background: Tyrosine (Tyr), Tryptophan (Trp) and 5-hydroxytryptamine (5-HT) are important amino acids in vivo and have been hypothesized to be involved in many mental disorders. We developed a rapid and sensitive HPLC method for simultaneous measurement of serum Tyr, Trp and 5-HT and explored the clinical significances of Tyr, Trp and 5-HT and the 5-HT/Trp ratio for patients with major depressive disorder (MDD) disease. Methods: Serum samples were deproteinized by 5% perchloric acid and separated on an Atlantis C18 column (4.6×150mm, 5μm) with the mobile phase consisting of 0.1mol/l KH 2PO 4 and methanol (85:15, V/V).The eluates were monitored by the fluorescence detection with programmed wavelength. Results: Analysis was achieved in <. 12.0. min. The limits of quantification were 0.014, 0.005, and 0.024μmol/l for Tyr, Trp and 5-HT, respectively. Reproducibility and recovery were satisfactory. Tyr, Trp and 5-HT and the 5-HT/Trp ratio were significantly decreased in patients with MDD. Conclusions: In diseases, like MDD, Tyr, Trp and 5-HT play an important role. This method can potentially be applied as prognostic or diagnostic tool or even to follow the evolution of the illness or of the treatment. © 2012.

Wu S.,The First Peoples Hospital
Chinese Journal of Rehabilitation Medicine | Year: 2013

Objective: To study the effects of manipulation treatment on visual P300 potential of patients in cognitive function assessment after stroke. Method: Forty-eight patients were randomly divided into two groups, special manipulation treatment group (25 cases) and control group (23 cases). Patients in manipulation group were regularly given a passive quantitative movement on affected joints 1h/time, 2times/d, for lmonth, while patients in control group were irregularly given a passive movement or ordered to perform an autonomic movement. The visual P300 potential and mini-mental state examination (MMSE) assessment were administered pre-treatment and post-treatment (after one month) respectively. Result: (1) The latency of visual P300 was severely shortened after the manipulation treatment, and the amplitude of visual P300 wave was heightened significantly. (2) MMSE score increased after manipulation treatment, but the difference was not significant between 2 groups (P ≤ 0.05). Conclusion: Visual P300 indexes might be useful in measuring cognitive function changes after stroke and the special manipulation treatment could also improve the patient's cognitive function.

Zou H.,the First Peoples Hospital
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2012

To explore the clinical manifestations, diagnosis and treatment of primary thyroid B cells lymphoma. Eight cases of primary thyroid B cells lymphoma were retrospectively analysed, which were combinely diagnosed and treated. Follow up was being for two to seven years. Three cases were loss of visit, one case died, and four cases survived. Two-year survival rate was 85.1%, and five-year survival rate was 76.3%. A combination of various diagnostic and therapeutic methods of primary thyroid B cells lym-phoma can improve the diagnosis rate, reduce the misdiagnosis rate and improve the curative effect.

Shi S.,the First Peoples Hospital
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2011

To analyze the clinical characteristics, diagnosis and treatment course and clinical effect of non-invasive fungal rhino-sinusitis, and to investigate the diagnostic and treating methods and factors affecting the clinical outcome. A retrospective study was conducted on 111 patients who were diagnosed with noninvasive fungal rhino-sinusitis from 2005 to 2009 in our department. Clinical symptoms, endoscopic and CT examinations, surgical methods, surgical outcomes and the treatment of the recurrent cases were reviewed. Eighty-six cases were reassured of the non-invasive fungal rhino-sinusitis by means of clinical symptoms, endoscopic and CT examinations. All the patients who underwent functional endoscopic sinus surgery showed satisfying clinical effect and no complications occurred. During the follow-up, recurrence was found in 12 cases 1 to 5 years postoperatively, and 7 were cured after medication and debridement under endoscope in outpatient department while the clinical outcome of the other 5 was unsatisfactory. Non-invasive fungal rhino-sinusitis is distinctive in endoscopic and CT examination which is different from common chronic rhino-sinusitis, and endoscopic sinus surgery is an effective treatment for the disease. Radical debridement and successful drainage of the nasal sinus is the key factor affecting the effect of the treatment and clinical outcome.

Xiao S.H.,The First Peoples Hospital
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases | Year: 2011

To evaluate the difference in diagnostic accuracy and complication rate and operational procedures between manual and coaxial automated percutaneous lung biopsy under CT-guidance. Ninety-seven patients [aged from 19 - 87 (50 ± 17) years], with undiagnosed pulmonary lesions underwent CT-guided percutaneous lung biopsy from June 2006 to May 2010 in this hospital. The final diagnosis was confirmed by surgical pathology or clinical follow-up. Fifty-three patients (32 males and 21 females) underwent manual percutaneous lung biopsy, while 44 patients (29 males and 15 females) underwent percutaneous lung biopsy by using a coaxial automated biopsy device (biopsy gun). Biopsies were carried out by the same physician in all cases with the 18G vitesse needle made by optimed company in German. Biopsy guns made by the same company were used in coaxial automated biopsy group. The puncture point, angle and depth were set according to the CT images under the guidance by CT grating. Generally, the puncture was directed vertically towards the lesions closest to the chest wall. In the manual biopsy group, the diagnostic accuracy was 91% (48/53), the pneumothorax rate was 11% (6/53), and the hemorrhage rate was 15% (8/53), while in the coaxial automated biopsy group, they were 75% (33/44), 30% (13/44) and 27% (12/44), respectively. The diagnostic accuracy was higher while the pneumothorax rate was lower in the manual biopsy as compared to the coaxial automated biopsy group.

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