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Yu Q.-B.,The First Municipal Hospital of Qinhuangdao | Deng J.-F.,The First Municipal Hospital of Qinhuangdao | Gao D.-X.,The First Municipal Hospital of Qinhuangdao | Song H.,The First Municipal Hospital of Qinhuangdao | And 3 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2014

BACKGROUND: Intra-articular injection of sodium hyaluronate is an effective method for the treatment of knee osteoarthritis, with significant effect and less adverse reactions, but the mechanism is unclear. OBJECTIVE: Through testing the malondialdehyde and superoxide dismutase levels in the synovial fluid of knee osteoarthritis before and after injection of sodium hyaluronate, to evaluate the clinical efficacy of sodium hyaluronate in the treatment of knee osteoarthritis. METHODS: Thirty-seven patients with knee osteoarthritis (40 knees) were enrolled and divided into mild (n=10, 10 knees), moderate (n=17, 18 knees), and severe (n=10, 12 knees) groups according to the Japan's knee osteoarthritis indications. Patients were subjected to intra-articular injection of 25 mg sodium hyaluronate, once a week for 5 weeks. The levels of malondialdehyde and superoxide dismutase in the synovial fluid before and 4 weeks after treatment were detected, and then clinical effects were evaluated based on the clinical scores according to the Japan’s knee osteoarthritis indications. RESULTS AND CONCLUSION: The indication rating results of the mild and moderate groups were decreased significantly 4 weeks after injection (P < 0.05), but there were no significant difference in the severe group before and after treatment. The malondialdehyde level in the synovial fluid was decreased obviously in the three groups at 4 weeks after injection (P < 0.05), while the level of superoxide dismutase was increased remarkably (P < 0.05). These findings indicate that sodium hyaluronate can treat knee osteoarthritis by reducing the malondialdehyde level and increasing superoxide dismutase level in the synovial fluid, but this method is more suitable for treatment of mild to moderate knee osteoarthritis. © 2014, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved. Source


Deng J.-F.,The First Municipal Hospital of Qinhuangdao | Gao D.-X.,The First Municipal Hospital of Qinhuangdao | Liu Z.-X.,The First Municipal Hospital of Qinhuangdao | Wu D.,The First Municipal Hospital of Qinhuangdao | And 5 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2014

BACKGROUND: Intra-articular injection of sodium hyaluronate has become a preventive and complementary therapy for knee osteoarthritis that can effectively relieve pain, protect the articular cartilage, and restore the joint function. OBJECTIVE: To observe the effects of sodium hyaluronate on nitric oxide and synovial thickness in patients with knee osteoarthritis. METHODS: Eighty patients with knee osteoarthritis (86 knees) were randomly selected and divided into mild, moderate, severe groups. Intra-articular injection of 25 mg sodium hyaluronate was done once a week for 5 consecutive weeks. At 4 and 12 weeks after treatment, all the patients were subjected to clinical scoring according to the Japanese Knee Osteoarthritis Measure. Thirty-seven patients (40 knees) who could make joint fluid and complete ultrasonic measurement was taken as a complete monitoring group that was also divided into three groups of mild, moderate, and severe. Levels of nitric oxide and synovial thickness were measured before and at 4 weeks after treatment. RESULTS AND CONCLUSION: At 4 weeks after treatment, the effective rates of mild, moderate and severe groups were 93%, 77% and 47%, respectively, and the total effective rate was 79%. At 12 weeks after treatment, the effective rates of mild, moderate and severe groups were 95%, 84% and 33%, respectively, and the total effective rate was 80%. In the complete monitoring group, the level of nitric oxide was reduced significantly in mild, moderate and severe patients at 4 weeks after treatment compared with before treatment (P < 0.05), but the synovial thickness had no difference in the mild and severe patients, and only moderate patients appeared to have thinner synovial thickness compared with before treatment (P < 0.05). Experimental findings suggest that sodium hyaluronate can reduce the level of nitric oxide and improve clinical efficacy in patients with knee osteoporosis, especially for mild and moderate knee osteoporosis patients. © 2014, Journal of Clinical Rehabilitative Tissue Engineering Research All Rights Reserved. Source

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