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Cao Y.,China Medical University at Heping | Cao Y.,The First Hospital of Liaoning Medical College | Qiu J.,The First Hospital of Liaoning Medical College | Wang B.,The First Hospital of Liaoning Medical College | And 2 more authors.
Cell Biochemistry and Biophysics | Year: 2014

The main objective of this study was to investigate the risk factors and clinical treatment of craniocerebral injury concurrent with acute kidney injury. A total of 220 patients who suffered from craniocerebral injury from March 2010 to March 2012 in our Hospital were prospectively analyzed. Craniocerebral injury was defined according to the medical history, the verification of CT, and some investigated scores. The acute kidney injury was defined as a relative 47 % increase of serum creatinine. The method of multivariate logistic regression analysis was used to evaluate the possible risk factors associated with post-craniocerebral injury concurrent with acute kidney injury. The clinical treatments of craniocerebral injury concurrent with acute kidney injury were also identified via experimental results, and the pathological mechanism of craniocerebral injury concurrent with acute kidney injury was found to be related to cerebral tissue lesions, but some potential factors were ambiguous. The incidence of acute kidney injury was 70.2 % with craniocerebral injury. In hospital, mortality of acute kidney injury patients was 31.2 %, which was 6.019 times of non-acute kidney injury patients (p < 0.01). The incidence of acute kidney injury in patients with craniocerebral injury was 58.3 %, which was significantly higher compared to moderate and mild groups (p < 0.01). Unconditional multivariate logistic regression analysis results revealed that lower score, elderly, and male were the independent predictors of acute kidney injury episodes. Finally, some important factors were worthy of detailed study and further investigation. © 2014, Springer Science+Business Media New York. Source


Xu N.,The First Hospital of Liaoning Medical College | Lei Z.,The First Hospital of Liaoning Medical College | Li X.-L.,Chinese Peoples Liberation Army | Zhang J.,The Hospital of Shanqiao Group of China Railway | And 7 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2013

Objectives: To explore the correlation between multi-slice spiral CT (MSCT) perfusion parameters and the expression of vascular endothelial growth factor (VEGF) as well as matrix metalloproteinase-2 (MMP-2) in breast cancer. Methods: Forty five breast cancer patients and 16 patients with benign breast tumor,both confirmed by pathology examination, were enrolled. All underwent MSCT perfusion imaging to obtain perfusion maps and data for parameters including blood flow (BF),blood volume (BV) and permeability surface (PS). Cancer patients did not receive treatmentprior to surgery. The expression of VEGF and MMP-2 were examined with both immunohistochemistry and Western blotting. Results: The levels of VEGF and MMP-2 by immunohistochemistry were significantly higher in the breast cancer group (P < 0.01) than the benign tumor group. Relative OD values from Western blotting were also higher in cancer cases (P < 0.05). Similarly, the mean MSCT perfusion parameters (BF, BV, PS) were significantly higher in the breast cancer group(P < 0.01), BF and BV positively correlating with VEGF expression (r = 0.878 and 0.809 respectively, P < 0.01); PS and VEGF and MMP-2 expression were also positively correlated (r= 0.860,0.786 respectively, P < 0.01). Conclusion: There is a correlation between breast cancer MSCTperfusion parameters and VEGF and MMP-2 expression, which might be useful for detection of breast lesions, qualitative diagnosis of breast cancer, and evaluation of breast cancer treatment. Source

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