Guo Y.-P.,The First Center Hospital of Bao Ding |
Wang C.-G.,The First Center Hospital of Bao Ding |
Liu X.,The First Center Hospital of Bao Ding |
Huang Y.-Q.,The First Center Hospital of Bao Ding |
And 7 more authors.
Current Therapeutic Research - Clinical and Experimental | Year: 2014
Background: The incidence of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and primary biliary cirrhosis has increased significantly in China. Information about the susceptibility or potential of autoimmune diseases in the general population is lacking. Objective: To explore the prevalence of antinuclear antibody (ANA) and its specificities in the general population in China. Methods: Twenty thousand nine hundred seventy sera samples were taken from the physical examination center in Baoding, China. Indirect immunofluorescence and line immunoassays were used to detect ANA and its specificities, respectively. Results: Samples from females had a higher prevalence of ANA than samples from males (χ2 = 278.55; P < 0.01). For both sexes, the prevalence of ANA positively correlated with age and there were significant differences among different age groups at 10-year intervals, except the 80 years group (P < 0.05). One thousand two hundred forty-three ANA-positive samples were further analyzed with line immunoassays. There was a significant difference among age groups and between sex groups in terms of the specific autoantibodies (P < 0.01). The autoantibodies with the top-3 positive frequencies were anti-Ro-52, anti-M2, and anti-SSA. Conclusions: There was a high prevalence of ANA positivity in the general Chinese population that seemed to be influenced by sex and age and correlated with specific autoantibodies. © 2014 The Authors.
Wang C.-G.,The First Center Hospital Of Bao Ding |
Ding Y.-L.,The First Center Hospital Of Bao Ding |
Han A.-P.,The First Center Hospital Of Bao Ding |
Hu C.-Q.,The First Center Hospital Of Bao Ding |
And 7 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015
The ischemia necrosis of limb frequently requires surgery of amputation. Lumbar plexus and sciatic nerve block is an ideal intra-operative anesthetic and post-operative antalgic technique for patients of amputation, especially for high-risk patients who have severe cardio-cerebrovascular diseases. However, the duration of analgesia of peripheral nerve block is hardly sufficient to avoid the postoperative pain and the usage of opioids. In this case, a 79-year-old man, with multiple cerebral infarcts, congestive heart failure, atrial flutter and syncope, was treated with an above knee amputation because of ischemia necrosis of his left lower limb. Dexmedetomidine 1 μg/kg was added to 0.33% ropivacaine for lumbar plexus and sciatic nerve block in this case for intra-operative anesthesia and post-operative analgesia. The sensory function was blocked fully for surgery and the duration of analgesia maintained 26 hours with haemodynamic stability and moderate sedation. The patient did not complain pain and require any supplementary analgesics after surgery. This case showed that adding 1 μg/kg dexmedetomidine to ropivacaine for lumbar plexus and sciatic nerve block may be a feasible and safe technique for high-risk patients for lower limb surgery of amputation. © 2015, E-Century Publishing Corporation. All rights reserved.
Hou L.,The First Center Hospital of Bao Ding |
Wang J.,The First Center Hospital of Bao Ding |
Lu D.,The First Center Hospital of Bao Ding |
Wang P.,The First Center Hospital of Bao Ding |
And 2 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2016
Reversible cerebral vasoconstriction syndrome is a kind of clinicoradiological syndrome reported recently. It is characterized as thunderclap headache and reversible vasoconstriction. However, headache is sometimes absent when reversible vasoconstriction happens. We report a case here admitted because of watershed infarction caused by reversible vasoconstriction without headache when happened in a coal house with poor ventilation in a cold season. © 2016, E-Century Publishing Corporation. All rights reserved.
PubMed | The First Center Hospital of Bao Ding
Type: Journal Article | Journal: Journal of molecular neuroscience : MN | Year: 2013
The cerebrospinal fluid-contacting nucleus (CSF-CN) may influence actual composition of the CSF for non-synaptic signal transmission via releasing or absorbing bioactive substances, which distributes and localizes in the ventral periaqueductal central gray of the brainstem. Previous studies demonstrated that CSF-CN was involved in neuropathic pain and morphine dependence. Thus, to identify whether extracellular signal-regulated kinase 5 (ERK5) distributed in the CSF-CN and its function on the formation and development of morphine physical dependence, morphine withdrawal-like behavioral test and immunofluorescent technique were used in this research. Morphine was subcutaneously injected by an intermittent and escalating procedure to induce physical dependence, which was measured by withdrawal symptoms. In this study, we found that horseradish peroxidase-conjugated toxin subunit B/p-ERK5 double-labeled neurons expressed in the CSF-CN of normal rats. ERK5 signaling pathway was remarkably activated by naloxone-precipitated withdrawal in the CSF-CN. Moreover, selective attenuation of p-ERK5 expression in the CSF-CN by lateral ventricle injection of BIX02188 could significantly relieve morphine withdrawal symptom. These findings confirmed that the activation of p-ERK5 in the CSF-CN might contribute to morphine physical dependence.