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Wang X.,The First Affiliated Hospital Of Xian Jiaotong Universityshaan Xi | Wang W.,The First Affiliated Hospital Of Xian Jiaotong Universityshaan Xi | Chen L.,The First Affiliated Hospital Of Xian Jiaotong Universityshaan Xi | Wang H.,The First Affiliated Hospital Of Xian Jiaotong Universityshaan Xi | Liu Y.,The First Affiliated Hospital Of Xian Jiaotong Universityshaan Xi
International Journal of Clinical and Experimental Medicine | Year: 2015

Aplastic anemia (AA) is a hematological disorder presenting with pancytopenia in peripheral blood and hypocellularity in bone marrow. AA patients with immunosuppressive therapy and granulocyte colony-stimulating factor treatment have a risk of development of acute leukemia including acute myeloid leukemia (M0, M1, M2, M4, M5, M6) and acute lymphoblastic leukemia. However, AA with transformation to acute promyelocytic leukemia (APL) has never been reported. Here, we reported a patient initially diagnosed with AA. while 19 years later, PML/RAR αfusion gene were detected and the patient was eventually diagnosed as APL. The diagnosis and management of this interesting case are discussed. © 2015 E-Century Publishing Corporation. All rights reserved. Source

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